Anticonflict effects of lavender oil and identification of its active constituents

Umezu, Toyoshi; Nagano, Kimiyo; Ito, Hiroyasu; Kosakai, Kiyomi; Sakaniwa, Misao; Morita, Masatoshi

doi:10.1016/j.pbb.2006.10.026

Cited by 120 publications

(99 citation statements)

References 28 publications

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“…From these findings, there derives a hypothesis of a different and pinene dose-dependent neurological response mechanism of the cardiac function. As reported by Umezu et al [63], experiments on mice indicated that the antistress property was reserved for other monoterpenes. However, they could not exclude a synergistic effect between all the components of the essential oil of lavender which was tested.…”

mentioning

confidence: 71%

“…Thus, when in synergy with other compounds, they could be beneficial in the treatment of cognitive impairments, due to their multifarious activities related to Alzheimer's disease [65]. It has also been shown that α-pinenes do not exhibit an oestrogenic activity [60] or a behavioural effect [63]. turpentine.…”

Section: R E V I E W P a P E R S Ijomeh 2009;22(4) 335mentioning

confidence: 99%

“…In a synergistic activity with other terpenes, they act against the fruit fly, Bemisia argentifolii [79]. In competition with α-pinenes, they seem more active as antifungal agents (on Fusarium culmorum, F. solani and containing α-pinenes [63]. Mercier [12] showed in in vivo and ex vivo studies a decrease in the rate of glycated haemoglobin after inhalation of oxidised turpentine vapours.…”

Section: Beta-pinenesmentioning

confidence: 99%

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The essential oil of turpentine and its major volatile fraction (α- and β-pinenes): a review

Mercier¹,

Prost²,

Prost³

2009

International Journal of Occupational Medicine and Environmental Health

147

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This paper provides a summary review of the major biological features concerning the essential oil of turpentine, its origin and use in traditional and modern medicine. More precisely, the safety of this volatile fraction to human health, and the medical, biological and environmental effects of the two major compounds of this fraction (α-and β-pinenes) have been discussed. Key words:Spirits of turpentine, α-pinene, β-pinene Received: July 1, 2009. Accepted : September 28, 2009. Address reprint request to B. Mercier, UPRES EA 4183 "Lipides & Signalisation Cellulaire", Faculté des Sciences de la Vie, Université de Bourgogne 6, Boulevard Gabriel, F-21000 Dijon (e-mail: beamercier@laposte.net). ORIGIN OF TURPENTINEThe term "essential oil of turpentine" designates the terpenic oil, obtained by hydrodistillation of the gem pine. It is also named the "spirits of turpentine", "pine tree terpenic", "pine oleoresin", "gum turpentine", "terpenes oil" or "turpentine from Bordeaux". Due to its pleasant fragrance, the terpenic oil is used in the pharmaceutical industry, perfume industry, food additives and other chemical industries (household cleaning products, paintings, varnishes, rubber, insecticides, etc.) [1]. TRADITIONAL MEDICINE AND TURPENTINEThe eminent doctors of antiquity, Hippocrates, Dioscoride or Galien, used the terpenic oil for its properties against lung diseases and biliary lithiasis. In France, Thillenius, Pitcairn, Récamier and Martinet recommended it against the blennorrhoea and cystitis. Chaumeton, Peschiez, Kennedi, Mérat prescribed it against the neuralgias. It was also used in the treatment of rheumatism, sciatica, nephritis, drop, constipation and mercury salivation. Those scientists also recognized that the terpenic oil may be a booster at an average dose and may have a paralyzing activity at high doses. In Germany, (Rowachol and Rowatinex), Slovenia (Uroterp) and Poland (Terpichol and Terpinex), the traditional drugs for renal and hepatic diseases (especially against cholesterol stones in the gall bladder and the bile duct) contain α-and β-pinenes [2]. Modern phytotherapy describes the following properties of the terpenic oil: antiparasitic, analgesic, revulsive, disinfectant (external use); balsamic, active on bronchial secretion and pulmonary and genito-urinary tract infections, haemostatic, dissolving gallstones, diuretic, antispasmodic, antirheumatic, deworming, being an antidote for poisonings caused by phosphorus [3] and improving the ciliary and secretory activity in patients who present chronic obstructive bronchitis (internal use ) [4]. ENVIRONMENTAL IMPACT OF THE VOLATILE TURPENTINE FRACTIONThe most volatile components of turpentine are two terpenes: alpha (α) and beta (β) pinenes. They are the dominant odorous compounds emitted by trees, shrubs, flowers and grasses [25]. In the lower troposphere, and depending on the weather conditions at the top of the trees, these compounds can react with OH° radicals, ozone, NO 3 radical and O 2 . Indeed, the electric field in the canopy at...

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mentioning

confidence: 71%

Section: R E V I E W P a P E R S Ijomeh 2009;22(4) 335mentioning

confidence: 99%

Section: Beta-pinenesmentioning

confidence: 99%

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The essential oil of turpentine and its major volatile fraction (α- and β-pinenes): a review

Mercier¹,

Prost²,

Prost³

2009

International Journal of Occupational Medicine and Environmental Health

147

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“…Additionally, lavender extracts inhibits glutamate-induced neurotoxicity and promotes anti-AchE activity enhancing the level of Ach in brain [31,32]. It is reported that lavender is an effective medical plant in treating inflammation, depression, stress and headache [28,33]. Lavender also is a strengthens of nervous system [34].…”

Section: Introductionmentioning

confidence: 99%

Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia

Soheili¹,

Tavirani²,

Saifeddine³

2012

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An important marker in neurodegenerative Alzheimer's disease (AD) is abnormal production of amyloid beta (Aβ) peptide leading to formation of plaques in the brain. Through decreasing Aβ aggregates, anti-inflammatory agents, phagocytosis, and proteolytic enzymes are known to decline risk of Aβ plaque formation. In the previous study we showed that aqueous extract of Lavandula angustifolia (lavender), with known anti-inflammatory effects, improves memory deficits in animal model of Alzheimer. Here, we assess if lavender play a role in clearance of Aβ plaques in the hippocampus. The Alzheimeric animals were created with intracerebroventricular injection of Aβ 1-42. To confirm formation of Aβ plaques, brain sections were stained by Congo red method. Twenty days post-injection they were administered with different doses (50, 100 and 200 mg/kg) of the aqueous extract of lavender for duration of 20 days. Our results demonstrated that 50 mg/kg of lavender not effectively influenced the Aβ plaques. On the other hand, the herbal medicine at the doses of 100 and 200 mg/kg markedly decreased the extent of Aβ aggregates. We concluded that the lavender extract dose dependently underlies elimination of Aβ plaques. The exact mechanism by which the herbal medicine removes the Aβ aggregates needs to be elucidated.

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“…Among these chemicals, a distinct class is composed by essential oils (EOs), of which some are used in indigenous medical systems to treat various conditions including mental illnesses (Umezu et al, 2001(Umezu et al, , 2006. From the dozens of components usually found in EOs, the monoterpenes and sesquiterpenes seem to be the main responsible for central nervous system (CNS) effects (Heuberger et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Sedative effects of essential oils obtained fromBaccharis uncinella

Ascari

Sens²,

Nunes

et al. 2011

Pharmaceutical Biology

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Anticonflict effects of lavender oil and identification of its active constituents

Cited by 120 publications

References 28 publications

The essential oil of turpentine and its major volatile fraction (α- and β-pinenes): a review

The essential oil of turpentine and its major volatile fraction (α- and β-pinenes): a review

Clearance of Amyloid Beta Plaques from Brain of Alzheimeric Rats by Lavandula angustifolia

Sedative effects of essential oils obtained fromBaccharis uncinella

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