Sedative effects of essential oils obtained from<i>Baccharis uncinella</i>

Ascari, Jociani; Sens, Sávio Luis; Nunes, Domingos Sávio; Wisniewski, Alberto; Arbo, Marcelo Dutra; Linck, Viviane M.; Lunardi, Paula; Leal, Mirna Bainy; Elisabetsky, Elaine

doi:10.3109/13880209.2011.634423

Cited by 19 publications

(15 citation statements)

References 37 publications

(31 reference statements)

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“…Sedation induced by (+)-spathulenol is in accordance with those described for the EO obtained from Baccharis uncinella, which showed sedative effects in mice and contains spathulenol as one of the major constituents (Ascari et al 2012). There were no other studies related to the central activity of (+)-spathulenol.…”

Section: Discussionsupporting

confidence: 85%

Anesthetic activity and bio-guided fractionation of the essential oil of Aloysia gratissima (Gillies & Hook.) Tronc. in silver catfish Rhamdia quelen

Benovit

Silva

Salbego

et al. 2015

An. Acad. Bras. Ciênc.

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This work aimed to determine the efficacy of the essential oil of A. gratissima as anesthetic for silver catfish, and to perform the bio-guided fractionation of essential oil aiming to isolate compounds responsible for the noted effects. Fish were submitted to anesthesia bath with essential oil, its fractions and isolated compounds to determine time of anesthetic induction and recovery. Eugenol (50 mg L -1 ) was used as positive control.Essential oil of A. gratissima was effective as an anesthetic at concentrations of 300 to 900 mg L -1 . Fish

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Section: Discussionsupporting

confidence: 85%

Anesthetic activity and bio-guided fractionation of the essential oil of Aloysia gratissima (Gillies & Hook.) Tronc. in silver catfish Rhamdia quelen

Benovit

Silva

Salbego

et al. 2015

An. Acad. Bras. Ciênc.

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“…Two essential oils containing BCP, basil one, administered intraperitoneally (at the doses of 100, 150 and 200 mg/kg), and Baccharis uncinella one, administered per os (at the doses of 50 or 100 mg/kg), exhibit significant sedative effect [39,40].…”

Section: β-Caryophyllene and Nervous Systemmentioning

confidence: 99%

β-Caryophyllene: A Sesquiterpene with Countless Biological Properties

et al. 2019

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β-Caryophyllene (BCP), a natural bicyclic sesquiterpene, is a selective phytocannabinoid agonist of type 2 receptors (CB2-R). It isn’t psychogenic due to the absence of an affinity to cannabinoid receptor type 1 (CB1). Among the various biological activities, BCP exerts anti-inflammatory action via inhibiting the main inflammatory mediators, such as inducible nitric oxide synthase (iNOS), Interleukin 1 beta (IL-1β), Interleukin-6 (IL-6), tumor necrosis factor-alfa (TNF-α), nuclear factor kapp a-light-chain-enhancer of activated B cells (NF-κB), cyclooxygenase 1 (COX-1), cyclooxygenase 2 (COX-2). Peroxisome proliferator-activated receptors alpha (PPAR-α) effects are also mediated by the activation of PPAR-α and PPAR-γ receptors. In detail, many studies, in vitro and in vivo, suggest that the treatment with β-caryophyllene improves the phenotype of animals used to model various inflammatory pathologies, such as nervous system diseases (Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, stroke), atherosclerosis, and tumours (colon, breast, pancreas, lymphoma, melanoma and glioma cancer). Furthermore, pre-clinical data have highlighted that BCP is potentially useful in Streptococcus infections, osteoporosis, steatohepatitis, and exerts anticonvulsant, analgesic, myorelaxing, sedative, and antidepressive effects. BCP is non-toxic in rodents, with a Lethal dose, 50% (LD50) greater than 5000 mg/kg. Nevertheless, it inhibits various cytochrome P450 isoforms (above all, CYP3A4), which metabolise xenobiotics, leading to adverse effects, due to drug levels over therapeutic window. All the reported data have highlighted that both pharmacological and toxicological aspects need to be further investigated with clinical trials.

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“…EO from Baccharis uncinella ‐containing BCAR at 50 or 100 mg/kg (p.o.) was found to exert a sedative effect in mice (Ascari et al, ). Similarly, the EO from Ocimum basilicum rich in BCAR at 100, 150, and 200 mg/kg (i.p.)…”

Section: Neuropharmacological Effects Of β‐Caryophyllenementioning

confidence: 99%

A systematic review on the neuroprotective perspectives of beta‐caryophyllene

Machado

Islam

Ali

et al. 2018

Phytotherapy Research

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Beta (β)-caryophyllene (BCAR) is a major sesquiterpene of various plant essential oils reported for several important pharmacological activities, including antioxidant, anti-inflammatory, anticancer, cardioprotective, hepatoprotective, gastroprotective, nephroprotective, antimicrobial, and immune-modulatory activity. Recent studies suggest that it also possesses neuroprotective effect. This study reviews published reports pertaining to the neuropharmacological activities of BCAR. Databases such as PubMed, Scopus, MedLine Plus, and Google Scholar with keywords "beta (β)-caryophyllene" and other neurological keywords were searched. Data were extracted by referring to articles with information about the dose or concentration/route of administration, test system, results and discussion, and proposed mechanism of action. A total of 545 research articles were recorded, and 41 experimental studies were included in this review, after application of exclusion criterion. Search results suggest that BCAR exhibits a protective role in a number of nervous system-related disorders including pain, anxiety, spasm, convulsion, depression, alcoholism, and Alzheimer's disease.Additionally, BCAR has local anesthetic-like activity, which could protect the nervous system from oxidative stress and inflammation and can act as an immunomodulatory agent. Most neurological activities of this natural product have been linked with the cannabinoid receptors (CBRs), especially the CB2R. This review suggests a possible application of BCAR as a neuroprotective agent.

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Sedative effects of essential oils obtained fromBaccharis uncinella

Cited by 19 publications

References 37 publications

Anesthetic activity and bio-guided fractionation of the essential oil of Aloysia gratissima (Gillies & Hook.) Tronc. in silver catfish Rhamdia quelen

Anesthetic activity and bio-guided fractionation of the essential oil of Aloysia gratissima (Gillies & Hook.) Tronc. in silver catfish Rhamdia quelen

β-Caryophyllene: A Sesquiterpene with Countless Biological Properties

A systematic review on the neuroprotective perspectives of beta‐caryophyllene

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