Anticoccidial Efficacy of Semduramicin in Battery Studies with Laboratory Isolates of Coccidia

Abstract

The anticoccidial activity of semduramicin against laboratory isolates of five species of poultry Eimeria was investigated. In laboratory scale battery trials, semduramicin at 20 to 30 ppm demonstrated broad-spectrum anticoccidial efficacy equivalent to salinomycin at 60 ppm. Also, semduramicin at 25 ppm was fed to uninfected cockerels in batteries for 21 days, and growth rate and feed efficiency were found to be equivalent to birds fed salinomycin at 60 ppm. Semduramicin was well tolerated when coadministered with tiamulin. Semduramicin demonstrated the same activity whether produced by semisynthesis or by direct fermentation.

Astonishing diversity of natural surfactants: 2. Polyether glycosidic ionophores and macrocyclic glycosides

“…Treatment of 43 with para-toluenesulfonic acid in acetonitrile/water yielded a mixture of two compounds, including semduramicin 46. This compound, also known as UK-61689, was obtained by fermentation of a mutant of the A. roseorufa and shows activity against both E. tenella and E. maxima (100). CP-91243 47 and CP-91244 48, along with 45, were isolated from a mutant of A. roseorufa ATCC 53666 (101).…”

Anticoccidial Efficacy and Chicken Toleration of Potent New Polyether Ionophores.

“…Battery anticoccidial efficacy and 21-day growth trials were conducted as described previously (Ricketts et al, 1992b). Efficacy trials were conducted against Eimeria tenella, Eimeria acervulina, Eimeria maxima, Eimeria necatrix, and Eimeria brunetti.…”

“…In the accompanying report (Ricketts et al, 1992b) the anticoccidial efficacy profile of ionophore CP-82,009 is detailed. The current study describes the efficacy of a second potent ionophore CP-84,657, structurally related to portmicin.…”

Determination of semduramicin in poultry feed at authorized level by liquid chromatography single quadrupole mass spectrometry

“…at dietary inclusion levels within the authorized concentration range (20-25 mg kg −1 complete feedingstuffs) [7,8]. The conditions of use of this feed additive including the authorized concentration range are specified in the corresponding Commission Regulation [9].…”