Anticoccidial Efficacy and Chicken Toleration of Potent New Polyether Ionophores.

Abstract

The current study investigated the anticoccidial activity of the ionophore CP-84,657 against laboratory strains of the five major pathogenic species of Eimeria that infect poultry. Based on lesion scores and weight gain, the ionophore CP-84,657 achieved broad-spectrum anticoccidial efficacy in battery trials at doses of 4 and 5 ppm that was equivalent to reference commercial ionophores. In uninfected chickens, 4 ppm of CP-84,657 was the highest dose that gave growth rate and feed efficiency equivalent to commercial agents over 21 days in batteries and 49 days in floor pens. Ionophore CP-84,657 is an efficacious, well-tolerated anticoccidial in chickens, with potency comparable to that of the most potent known ionophores.

Astonishing diversity of natural surfactants: 2. Polyether glycosidic ionophores and macrocyclic glycosides

“…Polyether 39 is among the most potent anticoccidial agents known, effectively controlling the major Eimeria species (E. tenella, E. acervulina, E. maxima, and E. necatrix) responsible for avian coccidiosis at doses of 5 mg/kg or less in feed. This compound is also active against certain Gram-positive bacteria in vitro as well as the spirochete S. hyodysenteriae, the causative agent in swine dysentery (94,95). The ionophores W341C 40 and CP-120509 41 (96) were produced by Streptomyces W341 (57).…”

Chemistry and Biod iversity of the Biologically Active Natural Glycosides

“…Compound 673 is among the most potent anticoccidial agents known, effectively controlling the major Eimeria species (E. tenella, E. acervulina, E. maxima, and E. necatrix) responsible for avian coccidiosis at doses of 5 mg/kg-1 or less in feed. This compound is also active against certain Gram-positive bacteria in vitro as well as the spirochete Serpulina hyodysenteriae, the causative agent of swine dysentery [442] [443]. W341C (674) and CP-120509 (675) [444] are produced by Streptomyces W341 [419].…”