Chemistry and Biod iversity of the Biologically Active Natural Glycosides

Dembitsky, Valery M.

doi:10.1002/cbdv.200490060

Cited by 87 publications

(50 citation statements)

References 420 publications

(323 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aglycones can be simple structures, such as short alkylic chain alcohols or fatty acids, as well as more complex ones, such as carotenoids, terpenoids, steroids, quinones, flavonoids, iridoids and alkaloids, among others [99]. Glycosides are widely distributed in nature and they can probably be found in all living organisms [100].…”

Section: General Considerations About Glycosidesmentioning

confidence: 99%

See 1 more Smart Citation

Occurrence, Biological Activities and Synthesis of Kaurane Diterpenes and their Glycosides

2007

View full text Add to dashboard Cite

This paper presents a review on kaurane diterpenes and their glycoside derivatives, covering aspects of their occurrence, biological activities and the synthesis of these natural products and their analogues. First, it shows and classifies diterpenes, in accordance with the already established structural criteria in the literature. Then, kaurane diterpenes are presented, focusing on their chemical structures, occurrence in the plant kingdom and their main, recently described, biological activities. Moreover, the most significant works, published between 1964 and November 2006, which describe the total synthesis or structural transformations of some kaurane diterpenes, including either semisynthetic and/or microbiological methodologies, are consisely reviewed. At this point, some general considerations on glycosides are introduced, and kaurane glycosides are presented and discussed on the basis of their toxic importance and occurrence in the plant kingdom, having focused on related aspects of their biological activities and the relationships between these activities and the structural factors of their molecules. Finally, the principal methods of glycosidation by enzymatic and chemical processes are both presented, and a few papers on the synthesis of kaurane glycosides are succinctly discussed. Molecules 2007, 12 456

show abstract

Section: General Considerations About Glycosidesmentioning

confidence: 99%

“…These kaurane glycosides and/or some related compounds had also been isolated from species of Xanthium spp. (Asteraceae), Wedelia biflora (Asteraceae), Cestum paraqui (Solanaceae) and Iphiona aucheri (Asteraceae) [99,124,125]. Wedeloside (81), an aminoglycoside isolated from Wedelia asperrima Benth.…”

Section: R' = R" = Hmentioning

confidence: 99%

Occurrence, Biological Activities and Synthesis of Kaurane Diterpenes and their Glycosides

2007

View full text Add to dashboard Cite

show abstract

“…Chemical shifts were calibrated indirectly through the glycine C = O signals recorded at 176.3 ppm relative to TMS. 1 H, 13 C, HSQC and DFQ NMR spectra for CDCl 3 or CD 3 OD solutions were obtained using a Bruker 400 MHz spectrometer. Chemical shifts (d) are reported in ppm downfield from TMS.…”

Section: Methodsmentioning

confidence: 99%

“…Aryl galactosides occur widely in nature [1,2]. Their diverse biological activities make them attractive targets for synthesis [3] as well as for structural investigation [4,5].…”

Section: Introductionmentioning

confidence: 99%

Phenyl galactopyranosides – 13 C CPMAS NMR and conformational analysis using genetic algorithm

et al. 2015

View full text Add to dashboard Cite

“…Natural aglycons have very diversified structures, such as lactones, fatty acids, quinones, antraquinones, terpenoids and steroids. Many glycosides possess biological activities such as antimicrobial, analgesic, anti-hypertensive, among others (1,7). Cardenolides are good examples of bioactive glycosides, possessing high cardiotonic (22) and cytotoxic (5) activities.…”

Section: Introductionmentioning

confidence: 99%

Novel agents for enzymatic and fungal hydrolysis of stevioside

Milagre¹,

Martins²,

Takahashi³

2009

Braz. J. Microbiol.

View full text Add to dashboard Cite

A comparative study on the potential of some biological agents to perform the hydrolysis of stevioside was carried out, aiming at establishing an alternative methodology to achieve the aglycon steviol or its rearranged derivative isosteviol, in high yields to be used in the preparation of novel bioactive compounds. Hydrolysis reactions were performed by using filamentous fungi (Aspergillus niger, Rhizopus stolonifer and Rhizopus arrhizus), a yeast (Saccharomyces cerevisiae) and enzymes (pancreatin and lipases PL250 and VFL 8000). Pancreatin showed the best hydrolytic activity, furnishing isosteviol at 93.9% of yield, at pH 4.0, using toluene as a co-solvent. Steviol was produced using both pancreatin at pH 7.0 (20.2% yield) and A. niger at pH 7 (20.8% yield).

show abstract

Chemistry and Biod iversity of the Biologically Active Natural Glycosides

Abstract: This review covers the literature on isolation, bioactivities, and structures of nearly 800 natural glycosides.

Cited by 87 publications

References 420 publications

Occurrence, Biological Activities and Synthesis of Kaurane Diterpenes and their Glycosides

Occurrence, Biological Activities and Synthesis of Kaurane Diterpenes and their Glycosides

Phenyl galactopyranosides – 13 C CPMAS NMR and conformational analysis using genetic algorithm

Novel agents for enzymatic and fungal hydrolysis of stevioside

Contact Info

Product

Resources

About