Anticoagulant‐related intracerebral hemorrhage

Kase, Carlos S.; Robinson, R. K.; Stein, Ronnie; DeWitt, L. D.; Hier, Daniel B.; Harp, D. L.; Williams, J. P.; Lr, Caplan; Mohr, J. P.

doi:10.1212/wnl.35.7.943

Cited by 187 publications

(92 citation statements)

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“…The question of whether VKAs-ICH has a predilection for particular brain regions remains unsettled. In a cohort of 435 supratentorial ICH (including 102 VKAs-ICH) aged ≥55 years, the same anatomic distribution as ours was found, 20 whereas in a small study of 24 VKAs-ICH, 21 and in a large populationbased study, 4 an excess of ICH associated with coagulopathy was found in the cerebellum. This discrepancy with our findings may be partly explained by different methodologies: the authors included patients with heparin or other coagulopathies.…”

Section: Discussionsupporting

confidence: 82%

Vitamin K Antagonists–Associated Cerebral Hemorrhages

Dequatre‐Ponchelle

Hénon

Pasquini

et al. 2013

Stroke

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Section: Discussionsupporting

confidence: 82%

Vitamin K Antagonists–Associated Cerebral Hemorrhages

Dequatre‐Ponchelle

Hénon

Pasquini

et al. 2013

Stroke

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“…The cases described include those arising from a ruptured aneurysm of the posterior inferior cerebellar artery, haemophilia A, supratentorial surgery and anticoagulants. [5][6][7][8] To the best of our knowledge, this rare form of cerebellar haemorrhage has not been reported from our environment. We describe the clinical presentation of an elderly lady presenting with vermal cerebellar bleed following undiagnosed hypertension.…”

Section: Introductionmentioning

confidence: 83%

Vermal cerebellar hemorrhage as the initial manifestation of undiagnosed hypertension

Iyagba

Onwuchekwa

2016

Int J Res Med Sci

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Vermal cerebellar haemorrhage is bleeding affecting the midline region of the cerebellum. It is uncommon, accounting for 5-13% of all intracerebral haemorrhages. It is a grave condition with a high mortality. The diagnosis must be made early, if not, most patients would die within 48 hours. A 70-year-old lady presented to the accident and emergency department with a six hours history of sudden onset generalized tonic-clonic seizures following activity and loss of consciousness. She was unconscious with a Glasgow coma score of 3/15 with neck stiffness, generalized hypotonia and globally diminished reflexes. Her blood pressure was 240/120 mmHg with a mean arterial pressure of 160 mmHg. The brain computerized tomographic scan showed a hyperdense area in the cerebellar vermis with extension to both hemispheres and fourth ventricle. Consciousness was regained after three weeks of conservative management following which she became extremely restless and noticed to have developed titubations with nystagmus of both eyes. She also developed intention tremors, scanning dysarthria, generalized hypotonia, dysmetria, dysdiadochokinesia and intentional bilateral tremors. Her recovery was slow and gradual. Once she was able to stand with support, she was noticed to have florid truncal ataxia, lower limbs ataxia, and titubations.

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“…ICH associated with anti-coagulant administration is frequently located in the cerebellum, 2,10) whereas the incidence of lobar ICH is high in patients with thrombocytopenia. 5) Conversely, hypertension in general is reportedly associated with deep cerebral hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Intracerebral Hemorrhage in Patients With Chronic Liver Disease

Hoya

Tanaka

Uchida

et al. 2012

Neurol. Med. Chir.(Tokyo)

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The characteristics of intracerebral hemorrhage (ICH) accompanying chronic liver disease (CLD) were investigated in ICH patients hospitalized between 1998 and 2008 divided into the CLD group (55 ICHs in 49 patients) and the idiopathic group without CLD (668 ICHs in 648 patients). The CLD group included a subgroup with liver cirrhosis (LC). Age, sex, history of hypertension, Glasgow Coma Scale (GCS) score on admission, and hematoma locations were reviewed. Outcomes on discharge and causes of inhospital death were also studied. Factors associated with life prognosis in CLD patients were investigated using uni-and multivariate analyses. History of hypertension and deep cerebral hemorrhage were less frequent in the LC subgroup compared to the idiopathic group. Distributions of GCS scores on admission were not significantly different, but incidence of in-hospital death was significantly higher in the CLD group than in the idiopathic group. LC was an independent prognostic factor for CLD patients, but hematoma enlargement was not. Death primarily due to ICH was less frequent in the CLD group than in the idiopathic group. In conclusion, hemostatic disorders seemed to be related to site of hemorrhage, but not to life prognosis in the CLD group. Prognosis was mainly worsened by non-neurological complications.

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Anticoagulant‐related intracerebral hemorrhage

Cited by 187 publications

References 0 publications

Vitamin K Antagonists–Associated Cerebral Hemorrhages

Vitamin K Antagonists–Associated Cerebral Hemorrhages

Vermal cerebellar hemorrhage as the initial manifestation of undiagnosed hypertension

Intracerebral Hemorrhage in Patients With Chronic Liver Disease

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