“…The evidence currently available on the use of ranitidine as a prokinetic agent pertains, for the vast majority, to experimental settings. Five single centred experimental non-randomised non-blinded crossover studies (Fioramonti et al, 1984;Bertaccini et al, 1985;Mizumoto et al, 1990;Kishibayashi et al, 1994;and Lidbury et al, 2012) investigated potential prokinetic properties of ranitidine both in vitro (Bertaccini et al, 1985;and Mizumoto et al, 1990) and/or in vivo on healthy conscious or anaesthetised dogs (Fioramonti et al, 1984;Bertaccini et al, 1985;Mizumoto et al, 1990;Kishibayashi et al, 1994;and Lidbury et al, 2012). Although four out of five studies (Fioramonti et al, 1984;Bertaccini et al, 1985;Mizumoto et al, 1990; and Kishibayashi et al, 1994) found some degree of gastrointestinal motility stimulation post-ranitidine administration, these results are difficult to compare and generalise due to the limited number of animals included in each study, different patient populations evaluated (conscious vs anaesthetised, starved vs non-starved), a variety of techniques employed to estimate GI motility and discordant dosing regimes or route of administration.…”