Anticholinergic therapies in the treatment of Parkinson's disease

Mechali, Omar; Xu, Limei; Huang, Ya; Shi, Mengji; Xie, Xingyu

doi:10.1002/mds.5556

Cited by 18 publications

(3 citation statements)

References 22 publications

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“…The processes by which acetylcholine may organize MSN networks in vivo are less well understood, although the conditions associated with disease states provide insight. Elevated cholinergic tone has been hypothesized to contribute to Parkinson’s disease symptoms, in particular akinesia and bradykinesia 28,45 , and our results support the idea that augmented cholinergic activity in disease states may promote a pathological synchronization of striatal networks, freezing the dorsal striatum in a state that inhibits movement. The present data offer mechanistic insight into the therapeutic benefits of anti-cholinergic compounds in the treatment of Parkinson’s disease 45,46 and other motor disorders associated with elevated cholinergic tone 28 .…”

Section: Discussionsupporting

confidence: 86%

“…Elevated cholinergic tone has been hypothesized to contribute to Parkinson’s disease symptoms, in particular akinesia and bradykinesia 28,45 , and our results support the idea that augmented cholinergic activity in disease states may promote a pathological synchronization of striatal networks, freezing the dorsal striatum in a state that inhibits movement. The present data offer mechanistic insight into the therapeutic benefits of anti-cholinergic compounds in the treatment of Parkinson’s disease 45,46 and other motor disorders associated with elevated cholinergic tone 28 . As recent studies have implicated phasic dopamine release as a mechanism within the striatum to promote movement 47,48 , our findings suggest that acetylcholine may act in opposition to this process.…”

Section: Discussionsupporting

confidence: 86%

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Unique contributions of parvalbumin and cholinergic interneurons in organizing striatal networks during movement

et al. 2019

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Striatal pavalbumin (PV) and cholinergic (CHI) interneurons are poised to play major roles in behavior by coordinating the networks of medium spiny cells that relay motor output. However, the small numbers and scattered distribution of these cells has made it difficult to directly assess their contribution to activity in networks of MSNs during behavior. Here, we build upon recent improvements in single cell calcium imaging combined with optogenetics to test the capacity of PVs and CHIs to affect MSN activity and behavior in mice engaged in voluntarily locomotion. We find that PVs and CHIs have unique effects on MSN activity and dissociable roles in supporting movement. PV cells facilitate movement by refining the activation of MSN networks responsible for movement execution. CHIs, in contrast, synchronize activity within MSN networks to signal the end of a movement bout. These results provide new insights into the striatal network activity that supports movement.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 86%

Unique contributions of parvalbumin and cholinergic interneurons in organizing striatal networks during movement

et al. 2019

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“…Anticholinergic drugs act by blocking acetylcholine receptors and aim to reestablish the balance between dopaminergic deficits and striatal cholinergic excess in PD 12 , 13 .…”

Section: Nondopaminergic Drugsmentioning

confidence: 99%

Guidelines for Parkinson’s disease treatment: consensus from the Movement Disorders Scientific Department of the Brazilian Academy of Neurology - motor symptoms

Saba

Maia

Cardoso

et al. 2022

Arq. Neuro-Psiquiatr.

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The treatment of Parkinson's disease (PD) is challenging, especially since it is considered highly individualized. The Brazilian Academy of Neurology has recognized the need to disseminate knowledge about the management of PD treatment, adapting the best evidence to the Brazilian reality. Thus, the main published treatment guidelines were reviewed based on the recommendations of group from the Movement Disorders Scientific Department of the Brazilian Academy of Neurology.

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Parkinson's Disease

2006

Wiley Handbook of Current and Emerging Drug Therapies

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Anticholinergic therapies in the treatment of Parkinson's disease

Cited by 18 publications

References 22 publications

Unique contributions of parvalbumin and cholinergic interneurons in organizing striatal networks during movement

Unique contributions of parvalbumin and cholinergic interneurons in organizing striatal networks during movement

Guidelines for Parkinson’s disease treatment: consensus from the Movement Disorders Scientific Department of the Brazilian Academy of Neurology - motor symptoms

Parkinson's Disease

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