Anticholinergic poisoning in colicky infants treated with hyoscyamine sulfate

Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives

“…Although commonly used, there are no randomized controlled trials establishing the safety and effi cacy of this medication in treating gastrointestinal disorders, particularly in children. Anticholinergic poisoning has been reported in some colicky infants treated with hyoscyamine [ 151 ].…”

Drugs Acting on the Gut: Prokinetics, Antispasmodics, Laxatives

“…It is available as oral tablets, extended [ 122,123 ] . Although commonly used, there are no randomized controlled trials establishing the safety and ef fi cacy of this medication in treating gastrointestinal disorders, particularly in children.…”

“…Although commonly used, there are no randomized controlled trials establishing the safety and ef fi cacy of this medication in treating gastrointestinal disorders, particularly in children. Anticholinergic poisoning has been reported in some colicky infants treated with hyoscyamine [ 122 ] . Dicyclomine is an m1-speci fi c muscarinic antagonist which has been used to treat symptoms of colic, irritable bowel syndrome and diverticulitis.…”

Medicinal Mishap: Dosing errors with Donnalix Infant Drops

“…Toxicity in colicky infants given anticholinergic drugs is well documented. 1,2 Neurological manifestations of excessive dosing range from sedation to irritability, agitation, seizures and coma.…”