Antichlamydial antibodies and citric acid in patients with chronic prostatitis

Ostaszewska-Puchalska, Iwona; Zdrodowska-Stefanow, B; Badyda, Jerzy; Galewska, Zofia

doi:10.1007/s00005-007-0006-x

Cited by 5 publications

(9 citation statements)

References 18 publications

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“…Specifically, granulocytes are the predominant component (50%–60%), followed by macrophages (20%–30%), T lymphocytes (2%–5%) and B lymphocytes 133. Leukocytospermia (>1 million per ml peroxidase-positive leukocytes in the semen) is present in approximately 10%–20% of infertile patients,34 and a large percentage of semen samples with leukocytospermia produce negative results in microbiological tests 3435. Finally, bacteriospermia and elevated seminal leukocytes are prevalent, but are not statistically associated 34…”

Section: Discussionmentioning

confidence: 99%

Male accessory gland inflammation prevalence in type 2 diabetic patients with symptoms possibly reflecting autonomic neuropathy

et al. 2014

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Male accessory gland inflammation or infection (MAGI) is a potentially underdiagnosed complication of type 2 diabetes (DM2); specifically, we reported in a recent study that the frequency of MAGI was 43% among DM2 patients. In previous studies, we have demonstrated that diabetic autonomic neuropathy (DAN) is associated with a peculiar ultrasound characterization of the seminal vesicles (SVs) in DM2 patients. The aim of the present study was to evaluate the frequency of MAGI in two different categories of DM2 patients (i.e. patients with and without symptoms that possibly reflect DAN) and the respective ultrasound characterizations. Sixty DM2 patients with a mean (± s.e.m.) age of 42.0 ± 6.0 years (range: 34–47 years) were classified according to the presence or the absence of symptoms that could possibly reflect DAN (group A: DM2 with symptoms possibly reflecting DAN, n = 28 patients and group B: DM2 without symptoms possibly reflecting DAN, n = 32 patients). The patients in Group A exhibited a significantly higher frequency of MAGI compared with those in group B patients (P < 0.05); moreover, the Group A patients exhibited a significantly higher frequency of ultrasound signs suggestive of vesiculitis (P < 0.05). Finally, the concentrations of lymphocytes but not the concentrations of the leukocytes in the semen were significantly higher (P < 0.05) in group A compared with group B.

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Section: Discussionmentioning

confidence: 99%

Male accessory gland inflammation prevalence in type 2 diabetic patients with symptoms possibly reflecting autonomic neuropathy

et al. 2014

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“…The current study is a continuation of research whose results were published earlier [ 17 , 27 ]. In the study conducted in 2006 a relationship was found between C. trachomatis infection of the prostate gland and the level of citric acid in EPS [ 27 ].…”

Section: Discussionmentioning

confidence: 68%

“…In the study conducted in 2006 a relationship was found between C. trachomatis infection of the prostate gland and the level of citric acid in EPS [ 27 ]. Its continuation in 2007 demonstrated a correlation between the occurrence of anti- C. trachomatis antibodies in serum and prostatic secretions and the level of citric acid in the gland [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

The evaluation of markers of prostatic inflammation and function of the prostate gland in patients with chronic prostatitis

Zdrodowska-Stefanow

Ostaszewska-Puchalska²,

Badyda³

et al. 2008

Arch. Immunol. Ther. Exp.

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Introduction: The aim of the study was to determine the numbers of polymorphonuclear (PMN) leukocytes and PMN elastase and citric acid concentrations in chronic prostatitis patients regardless of etiology and in those with Chlamydia trachomatis infection of the prostate gland. Materials and Methods: The study involved 46 patients with chronic prostatitis. Expressed prostatitc secretions (EPS) were obtained to determine the leukocyte count, PMN elastase (ELISA) and citric acid concentrations (UV method), and the occurrence of C. trachomatis infection (ligase chain reaction). Results: Increased PMN cell counts (≥10 per high-power field) were found in 73.9% of patients and increased PMN elastase concentration (<250 ng/ml) in 78.3%. In 44.4% of the patients the elastase concentration indicated moderate (250-1000 ng/ml) and in 55.6% acute infection (≥1000 ng/ml). Decreased citric acid concentration (<18.12 mg/ml) in the EPS was found in 65.2% of the men. C. trachomatis prostate infection was detected in 17.4% of the patients and all of these men had higher inflammation parameters and lower citric acid concentrations. Conclusions: C. trachomatis prostate inflammation was accompanied by an increase in inflammation markers and a decrease in citric acid concentration.

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“…However, in patients with leukocytospermia, seminal citric acid concentration (a marker of prostate function) appears to be lower, suggesting that prostatitis is the main cause of their presence in semen. Moreover, a large percentage of seminal fluid samples with leukocytospermia result negative to microbiological tests (19,25). In fact, bacteriospermia and elevated seminal leukocytes are prevalent, but not statistically associated (19).…”

Section: Discussionmentioning

confidence: 99%

Increased Lymphocyte Concentration in the Semen of Patients with Reduced Testicular Volume

et al. 2013

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Low testicular volume (TV) is associated with a decreased testicular function. Several studies explored the conventional sperm parameters and the endocrine function in patients with low TV. No other parameters have been examined. On the basis of these premises, the aim of this study was to evaluate a non-conventional seminal parameter: seminal lymphocyte characterisation in men with low TV compared with that of subjects with normal TV. A further comparison was made between fertile men and infertile patients with low or normal TV (78 patients). The testis was considered normal in size when it had a volume between 15 and 25 crrr', low-normal with a volume between 10 and 12 em" and hypotrophic when the volume was <10 cnr'. Statistically significant differences were observed in the following sperm parameters: percentage of immature germ elements, peroxidase-positive leukocyte concentration and CD45pos leukocytes (p<0.05). A correlation analysis showed the presence of a positive linear relationship between CD45pos leukocytes and the percentage of immature germ elements (r=0.88; p<0.05) and between CD45pos leukocytes and the percentage of spermatozoa with phosphatidylserine externalisation (r=0.90; p<0.05) as well as a negative linear relationship between the percentage of spermatozoa with normal morphology and the seminal CD45pos leukocyte concentration (r=-0.75; p<0.05). The results of this study showed that patients with low testicular volume «10 em') have a significantly increased CD45pos concentration that is associated with increased percentages of immature germ elements, spermatozoa with signs of early apoptosis, and spermatozoa with abnormal morphology.The testis is an oval-shaped organ that, in adult men, weighs approximately 20 g, has an average volume (TV) of 18.6±4.8 em' and dimensions ranging from 3.6 to 5.5 em in length and 2.1 to 3.5 ern in width. Within the testis, there are approximately 400-600 seminiferous tubules that are 70-80 em long and have a diameter of 0.12-0.13 mm, representing 80-90% of the total testicular volume (1). The testis consists of two structurally distinct compartments: the interstitial cell or Leydig cell compartment and the seminiferous tubule compartment, which contains germ cells and Sertoli cells. These two compartments are responsible for the two main testicular actions: the endocrine and the exocrine function (production of androgens and spermatozoa). In the clinical practice, TV can be estimated by a physical examination using an orchidometer, but it can be more objectively assessed by an ultrasound examination, which is less affected by factors such as scrotal effusions, varicose veins, intra-scrotal masses, testicular pain, and distinction with the adjacent anatomical structures (2). It has

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Antichlamydial antibodies and citric acid in patients with chronic prostatitis

Cited by 5 publications

References 18 publications

Male accessory gland inflammation prevalence in type 2 diabetic patients with symptoms possibly reflecting autonomic neuropathy

Male accessory gland inflammation prevalence in type 2 diabetic patients with symptoms possibly reflecting autonomic neuropathy

The evaluation of markers of prostatic inflammation and function of the prostate gland in patients with chronic prostatitis

Increased Lymphocyte Concentration in the Semen of Patients with Reduced Testicular Volume

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