Male accessory gland inflammation prevalence in type 2 diabetic patients with symptoms possibly reflecting autonomic neuropathy

Condorelli, Rosita A.; Vicari, Enzo; Calogero, Aldo E.; Vignera, Sandro La

doi:10.4103/1008-682x.125911

Cited by 15 publications

(5 citation statements)

References 28 publications

(33 reference statements)

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“…The authors suggested that hypogonadism plays a critical role in the development of prostate inflammation [ 39 , 43 ]. Together with other results, this indicates that, in patients with both hypogonadism and prostate inflammation, TRT may alleviate inflammatory changes and prevent the development of BPH or LUTS [ 3 , 39 , 57 , 58 ]. Fig.…”

Section: Testes Prostate and Androgenssupporting

confidence: 72%

Correlation Between Testosterone Replacement Treatment and Lower Urinary Tract Symptoms

2021

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Lower urinary tract symptoms (LUTS) are a cluster of voiding symptoms, such as weak stream, hesitancy, intermittency, urinary frequency, urgency, and nocturia. LUTS are frequent in elderly men and it considered the ultimate clinical symptoms of benign prostatic hyperplasia. With aging, male hypogonadism is increased which is defined as decreased ability of the testes to produce sperm and sex steroids because of a pituitary/hypothalamic, or testicular deficiency. In academic andrology associations, the term “male hypogonadism” is commonly used to categorize testosterone deficiency. Testosterone deficiency syndrome (TDS) is defined as a decrease in serum testosterone accompanied by symptoms such as libido decrease, depressive disorder, erectile dysfunction, and fatigue. Although the mechanism about testosterone-replacement therapy (TRT) effects on men with hypogonadism is not yet identified, TRT has been shown to effectively relieve the symptoms of TDS as well as LUTS by several studies. Although the present review demonstrates the effectiveness and safety of TRT in men with TDS by prior studies, future large scale of clinical trials should be conducted to present more high-quality evidence to clinicians and patients.

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Section: Testes Prostate and Androgenssupporting

confidence: 72%

Correlation Between Testosterone Replacement Treatment and Lower Urinary Tract Symptoms

2021

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“…Similar considerations should also be applied to the epididymal US feature, since signs of inflammation or neuropathy on US have been revealed to promote the diagnosis [3,5].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, scientific interest for the potential male reproductive consequences of diabetes mellitus (DM) has been growing [1]. The greatest attention has been given to patients with type 2 DM (DM2), mainly because of its greater prevalence and clearer pathogenic mechanisms (hypogonadism, oxidative stress, neuropathy, sexual dysfunction) [1,2,3,4]. However, data concerning sperm quality also emerge in type 1 DM (DM1) patients.…”

Section: Introductionmentioning

confidence: 99%

Poor Efficacy of L-Acetylcarnitine in the Treatment of Asthenozoospermia in Patients with Type 1 Diabetes

Condorelli

Calogero

Cannarella

et al. 2019

JCM

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Introduction. In recent years, research has focused on the impact that diabetes mellitus (DM) has on male reproductive function. The available evidence has mainly considered type 2 DM (DM2). However, we have previously shown that type 1 DM (DM1) also affects male reproductive health. Given the efficacy of carnitine in the treatment of male infertility, a topic that merits further investigation is its role in the treatment of infertile patients with DM1. Aim. To investigate the efficacy of carnitines for the treatment of asthenozoospermia in DM1 patients. Methods. This was a two-arm single-blind, randomized control trial. The patients enrolled in this study were assigned to the group receiving L-acetylcarnitine (LAC) (1.5 g daily for 4 months) or to the group receiving LAC (same dosage) plus L-carnitine (LC) (2 g daily for 4 months). Serum-glycated hemoglobin levels did not differ significantly after either of the two treatments given. Administration of LAC plus LC showed greater efficacy on progressive sperm motility than single therapy (increase 14% vs. 1% after treatment, respectively). Discussion. The results of this study showed that the administration of LAC plus LC is more effective than the administration of LAC alone. The lower efficacy of LAC alone could be due to the lower overall administered dosage. Alternatively, a selective defect of carnitine transporters at an epididymal level could be hypothesized in patients with DM1. Further studies are needed to clarify this point.

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“…Up to 40% of men with diabetes may complain of ejaculatory dysfunction[ 99 ]. Of these PE, DE, AE, and RE are the most common and the focus of this discussion[ 100 - 113 ].…”

Section: Diabetes-related Ejaculatory Dysfunctionsmentioning

confidence: 99%

Ejaculatory dysfunction in men with diabetes mellitus

Mostafa¹,

Abdel‐Hamid²

2021

WJD

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Diabetes mellitus (DM) is a metabolic disorder that is characterized by elevated blood glucose levels due to absolute or relative insulin deficiency, in the background of β-cell dysfunction, insulin resistance, or both. Such chronic hyperglycemia is linked to long-term damage to blood vessels, nerves, and various organs. Currently, the worldwide burden of DM and its complications is in increase. Male sexual dysfunction is one of the famous complications of DM, including abnormal orgasmic/ejaculatory functions, desire/libido, and erection. Ejaculatory dysfunction encompasses several disorders related to DM and its complications, such as premature ejaculation, anejaculation (AE), delayed ejaculation, retrograde ejaculation (RE), ejaculatory pain, anesthetic ejaculation, decreased ejaculate volume, and decreased force of ejaculation. The problems linked to ejaculatory dysfunction may extend beyond the poor quality of life in diabetics as both AE and RE are alleged to alter the fertility potential of these patients. However, although both diabetes patients and their physicians are increasingly aware of diabetic ejaculatory dysfunction, this awareness still lags behind that of other diabetes complications. Therefore, all these disorders should be looked for thoroughly during the clinical evaluation of diabetic men. Besides, introducing the suitable option and/or maneuvers to treat these disorders should be tailored according to each case. This review aimed to explore the most important findings regarding ejaculatory dysfunction in diabetes from pre-clinical and clinical perspectives.

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Male accessory gland inflammation prevalence in type 2 diabetic patients with symptoms possibly reflecting autonomic neuropathy

Cited by 15 publications

References 28 publications

Correlation Between Testosterone Replacement Treatment and Lower Urinary Tract Symptoms

Correlation Between Testosterone Replacement Treatment and Lower Urinary Tract Symptoms

Poor Efficacy of L-Acetylcarnitine in the Treatment of Asthenozoospermia in Patients with Type 1 Diabetes

Ejaculatory dysfunction in men with diabetes mellitus

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