1986
DOI: 10.1016/s0190-9622(86)70217-x
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Anticentromere antibody in localized scleroderma

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Cited by 47 publications
(18 citation statements)
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“…The antibody has frequently been detected in cases of primary biliary cirrhosis [ 10. 111 and in cases of Raynaud's phenomenon alone [2,7,12]. Additionally, this antibody has been reported to be present occasionally in cases of systemic lupus erythematosus [2,7,13], localized scleroderma [14][15][16] and the blood relatives of patients with systemic scle rosis [5. 17.…”
Section: Discussionmentioning
confidence: 99%
“…The antibody has frequently been detected in cases of primary biliary cirrhosis [ 10. 111 and in cases of Raynaud's phenomenon alone [2,7,12]. Additionally, this antibody has been reported to be present occasionally in cases of systemic lupus erythematosus [2,7,13], localized scleroderma [14][15][16] and the blood relatives of patients with systemic scle rosis [5. 17.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies have shown that ANA is detected in 4680% of patients with localized scleroderma, as tested with cultured cells, and that the most common pattern of nuclear immunofluorescence is homogeneous (3)(4)(5). However, the antigens that are recognized by the ANA in localized scleroderma remain to be determined.…”
mentioning
confidence: 97%
“…ANA have been detected in 46-80% of patients with localized scleroderma [1][2][3][4][5][6]. Furthermore, we have demonstrated that antihistone antibodies (AHA) are positive in 47% of patients with localized scleroderma and in particular in 87% of patients with generalized morphea, suggesting that the major antigens recognized by ANA are nuclear histones [6,10].…”
Section: Abstract Cd4 · Cd8 · Systemic Sclerosis · Localized Sclerodmentioning
confidence: 99%
“…Immunologic bases are generally considered to be closely involved in the induction of localized scleroderma, since this disorder has been reported to be accompanied by various immunologic abnormalities, such as antinuclear antibodies (ANA), anti-single-stranded DNA (antissDNA) antibody, rheumatoid factor (RF), and lupus erythematosus cell phenomenon [1][2][3][4][5][6][7][8][9]. ANA have been detected in 46-80% of patients with localized scleroderma [1][2][3][4][5][6].…”
Section: Abstract Cd4 · Cd8 · Systemic Sclerosis · Localized Sclerodmentioning
confidence: 99%