Anticardiolipin Antibodies: Detection by Radioimmunoassay and Association With Thrombosis in Systemic Lupus Erythematosus

Harris, E. N.; Ml, Boey; Mackworth‐Young, Charles; Gharavi, Azzudin E.; Patel, Bijal; Loizou, S.; Hughes, G. R. V.

doi:10.1016/s0140-6736(83)91267-9

Cited by 1,317 publications

(560 citation statements)

References 15 publications

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“…Moreover, it can be anticipated that people might abstain from donating blood during temporary disease states, e.g., upper respiratory infections. There was a low prevalence of increased levels of anticardiolipin antibodies in the control subjects; this low frequency in normal subjects has also been reported by others (1).…”

Section: Discussionsupporting

confidence: 85%

“…Antibodies against cardiolipin were determined essentially as described by Harris et al (1); however, we used an enzymelinked immunosorbent assay (ELISA) technique and alkaline phosphatase-conjugated monospecific anti-human y chain or anti-p chain antibodies (Orioq Diagnostica, Espoo, Finland). The monospecificity of the conjugated antibodies was established in the ELISA by testing reactions with immunoglobulins of defined isotypes other than the specific ones.…”

Section: Methodsmentioning

confidence: 99%

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Anticardiolipin antibodies in patients with systemic lupus erythematosus

Sturfelt

Nived

Norberg

et al. 1987

Arthritis & Rheumatism

122

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We studied a group of 59 unselected patients with systemic lupus erythematosus (SLE); these patients were from a defined population who lived in southern Sweden. We found that serum concentrations of anticardiolipin antibodies were increased in 32 SLE patients found. Serial serum samples from 28 patients (12 patients were from the epidemiologic cohort) were analyzed. Sixteen of these 28 patients (57.1%) had increased levels of anticardiolipin antibodies; in most cases, there was no variation in these values with regard to clinical disease Bares or treatment. Increased concentrations of anticardiolipin were observed in 4 patients with cerebral infarction. However, very high concentrations of anticardiolipin antibodies were observed in several patients with inactive SLE who had no history of thrombosis or thrombocytopenia. Our results underscore the importance of studying unselected patient groups when

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Section: Discussionsupporting

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Anticardiolipin antibodies in patients with systemic lupus erythematosus

Sturfelt

Nived

Norberg

et al. 1987

Arthritis & Rheumatism

122

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“…We also found that there was no correlation between anticardiolipin antibody levels and anti-double-stranded DNA (dsDNA) antibody levels by linear regression analysis (r = 0.16) (2).…”

Section: Comment On Isenberg Articlementioning

confidence: 82%

“…We studied 49 female and 3 male patients with a diagnosis of "definitive" or "classic" RA according to criteria of the American Rheumatism Association (2). All patients had positive agglutination tests for rheumatoid factor.…”

Section: (1)mentioning

confidence: 99%

HLA—DR4 and rheumatoid arthritis in Mexican mestizos

Benavides

Silva

Cervantes

et al. 1984

Arthritis & Rheumatism

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“…Level of anti-DNA antibody and Rose-Waaler titer were normal. After other possible chronic inflammatory connective tissue diseases were excluded, the patient was diagnosed as having primary Sjogren's syndrome, according to the Copenhagen criteria (2). Primary Sjogren's syndrome is an autoimmune disease.…”

Section: Ta the Editormentioning

confidence: 99%