Anticardiolipin antibodies in patients with systemic lupus erythematosus

Sturfelt, Gunnar; Nived, Ola; Norberg, Renée; Thorstensson, Rigmor; Krook, Katarina

doi:10.1002/art.1780300404

Cited by 122 publications

(35 citation statements)

References 13 publications

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“…A number of clinical studies have shown that aCL are found in about 40% patients with SLE (Koike et al, 1984;Sturfelt et al, 1987;Ghirardello et al, 1994). Concerning the immunoglobulins of aCL, it is reported that there is IgG, IgM, or IgA isotypes .…”

Section: Discussionmentioning

confidence: 99%

Risk of arterial thrombosis in patients with anticardiolipin antibodies and lupus anticoagulant

et al. 1997

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The relationship between arterial or venous thrombosis and the levels of anticardiolipin antibodies (aCL) and/or existence of lupus anticoagulant (LA) was studied. The 141 patients with systemic lupus erythematosus (SLE) were divided into four groups: aCL single positive (25 cases), LA single positive (11 cases), aCL and LA double positive (25 cases), aCL and LA double negative (80 cases). The prevalence of thrombosis was higher in aCL and LA double positive patients (21/25 cases, 84.0%, P < 0.01) than that in aCL single positive patients (4/25 cases, 16.0%), LA single positive patients (1/11 cases, 9.1%) and double negative patients (3/80 cases, 3.8%). Furthermore, in these double positive patients, all patients (10/10 cases) with a high positive level of aCL (>10 units/ml) had arterial thrombosis, whereas only 2/15 patients (13.3%) with a low positive level of aCL (3–10 units/ml) were affected. Venous thrombosis was frequently found in the low positive group (9/15 cases, 60.0%). On the contrary, none of 105 LA negative patients had arterial thrombosis and only seven (6.7%) had venous thrombosis. These findings indicate that a high aCL activity combined with a LA positive result might be a risk factor for arterial thrombosis.

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Section: Discussionmentioning

confidence: 99%

Risk of arterial thrombosis in patients with anticardiolipin antibodies and lupus anticoagulant

et al. 1997

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“…18, 45 The etiology and significance of these marked fluctuations in titers is presently unknown. We did not find a consistent reduction in IgG aCL titer with the use of corticosteroids (nϭ9).…”

Section: Verro Et Al November 1998mentioning

confidence: 99%

Cerebrovascular Ischemic Events With High Positive Anticardiolipin Antibodies

Verro¹,

Levine²,

Tietjen³

1998

Stroke

101

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Background and Purpose-The aim of our study was to characterize the patient profile and prognostic value associated with high positive IgG (Ͼ100 GPL) anticardiolipin antibodies (aCL). Methods-We studied the clinical, laboratory, radiological, and prospective historical features of ischemic cerebrovascular disease in patients with Ͼ100 GPL titers. From our neurology department, 27 consecutive patients were prospectively identified and followed up (mean follow-up time, 34 months). Results-The mean age of our cohort was 41 years. Lupuslike illness occurred in 3; 23 had primary antiphospholipid syndrome, including 3 who met criteria for Sneddon's syndrome; 1 patient had progressive systemic sclerosis. Cerebral infarcts occurred in 74% and were recurrent in 37%. Systemic ischemic events, most commonly deep vein thrombosis, occurred in 37%. Tobacco use was documented in 85%, hyperlipidemia in 74%, hypertension in 44%, and diabetes mellitus in 7% of patients. A prominent headache history was present in 67%. Lupus anticoagulant (LA) was present in 72%, approximately one half had positive antinuclear antibodies and thrombocytopenia, and one quarter had a false-positive VDRL. We compared mean GPL levels in patients testing positive for specific laboratory features of antiphospholipid syndrome with those testing negative for these parameters. Only the LA(ϩ) group had a significantly higher mean GPL than the LA(-) group (Pϭ0.006). Brain imaging showed nonlacunar infarcts in 73% and lacunes in 12%. Of 19 cerebral angiograms, 5 (26%) showed large-vessel occlusive disease and 6 (32%) branch obstruction. Echocardiograms were abnormal in 75%: thickened left-sided valves in 33% and vegetations in 12%. Recurrent cerebrovascular ischemic events were observed in 96%, with transient events (mean rate, 25%/y) occurring 5 times more frequently than strokes (mean rate, 5%/y). Using a standardized disability scale blinded to aCL titer, neurological impairment was severe in 7%, moderate in 30%, and mild or nonexistent in 63%, and unrelated to mean GPL value (Pϭ0.567). Titers fluctuated greatly for individual patients, and most did not consistently test as highly positive. An analysis of fluctuation in symptom severity with concurrent GPL values did not show a statistically significant correlation. Compared with historical controls having a wide range of positive titers, the presence of high IgG aCL titers did not confer a worse prognosis for disability and recurrent ischemic events. Conclusions-Our data suggest that cerebrovascular events associated with high positive GPL are frequently multiple and minor (with no disability-titer correlation), present in relatively young patients, and often associated with tobacco abuse, hyperlipidemia, LA, systemic ischemic events, and occult cardiac disease. (Stroke. 1998;29:2245-2253.)

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“…10 A number of other manifestations may occur in SLE,most of which are associated with antiphospholipid and anticardiolipin antibodies, such as venous and arterial thrombosis, 11 recurrent fetal loss, 12 pulmonary hypertension, 13 endocardial disease seizures, and migraine. 14 But in our patient antiphospholipid and anticardiolipin antibody were negative.…”

Section: Discussionmentioning

confidence: 99%

A Lady with Systemic Lupus Erythematosus and Mitral Stenosis

Mm¹,

Hoque

Khan

et al. 2017

Bangladesh Heart J

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Abstract:Mitral stenosisis a valvular heart disease caused by a number of diseases. Chronic rheumatic fever is the most important cause. Among rare causes, some rheumatoid diseases like SLE may involve cardiovascular system causing libman-sacks endocarditis,pericardial diseases and other valvular lesions mostly associated with positive antiphospholipid and anticardiolipin antibody.Here, we presented a case of rheumatic mitral valvular heart disease having systemic lupus erythromatosus but negative antiphospholipid and anticardiolipin antibody.

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Anticardiolipin antibodies in patients with systemic lupus erythematosus

Cited by 122 publications

References 13 publications

Risk of arterial thrombosis in patients with anticardiolipin antibodies and lupus anticoagulant

Risk of arterial thrombosis in patients with anticardiolipin antibodies and lupus anticoagulant

Cerebrovascular Ischemic Events With High Positive Anticardiolipin Antibodies

A Lady with Systemic Lupus Erythematosus and Mitral Stenosis

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