Anticancer s-Triazine Derivatives: A Synthetic Attribute

Abstract

: 1, 3, 5-Triazine (s-Triazine) is a versatile nucleus to design and develop potent bioactive molecules for drug discovery particularly in cancer therapy. The aim of this review is to present the most recent trends in the field of synthetic strategies made for functionalized triazine derivatives active against cell proliferation. This review article covers synthesis of aryl methyl amino, morpholino, triamino substituted triazines, antimitotic agents coupled triazines and many more. Many 1,3,5-triazine derivatives, both hetero-fused and uncondensed, have shown remarkable antitumor activities. We have highlighted various derivatives with 1, 3, 5-triazine core which targeting different kinases with an aim to help researchers for developing new 1, 3, 5-triazine derived compounds for antitumor activity

Greener approach toward synthesis of biologically active s‐Triazine (TCT) derivatives: A recent update

“…1,3,5‐Triazine or symmetrical triazine is considered to be an exceptional synthon in chemistry which shares majority of chemical interactions to proceed through, coordination, electrostatic and aromatic‐stacking interactions, charge‐transfer attractions [10–11]. Triazine derivatives show a wide variety of biological applications such as antimicrobial [12], ant tuberculosis [13], anticancer [14], antiviral [15], and antimalarial [16] etc. (Figure 1).…”