Anticancer properties, apoptosis and catecholase mimic activities of dinuclear cobalt(II) and copper(II) Schiff base complexes

Ahamad, M. Naqi; Iman, Khushboo; Raza, Kausar; Kumar, Manjeet; Ansari, Azaj; Ahmad, Musheer; Shahid, M.

doi:10.1016/j.bioorg.2019.103561

Cited by 48 publications

(20 citation statements)

References 84 publications

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“…In the complex 1 the dependence of the shift of these bands on the solvent polarity was not observed but in 2, the value of a shift increased together with a decrease in the solvent polarity. Additionally, in the absorption spectra the presence of low intensity absorption bands from [50,51] between 575-666 nm (1) and in the range of 500-626 nm (2) was noted. This results from the square pyramidal environment of the copper atoms shifted towards the apical chloride anion in 1 and significantly deformed square pyramidal geometry with the shared edge and the non-bridging Cl1 and Cl2 in the apical positions of the copper ions in 2.…”

Section: Uv-vis and Fluorescence Spectroscopymentioning

confidence: 99%

“…They form ab layers due to π-π interactions between N30 and C1 rings and C15-H15B•••N30 ring interactions. The crystal network is completed by contacts among different planes assured by C27-H27 [Cu 2 (L2)Cl 3 ]0.5MeCN (2) [Cu 2 Cl 3 (L2)]•0.5MeCN (2) crystallizes in the monoclinic C2 space group with Flack parameter at 0.007(2) which indicates that the absolute structure is correct and the pure enantiomer was obtained. In the asymmetric unit, the whole molecule derived from the above formula was found.…”

Section: Structure Descriptionmentioning

confidence: 99%

“…The exchange interaction between two Cu(II) ions (S A = S B = 1 2 ) in 2 was described by the model of binuclear units realized through a chloride and an oxide bridge together with various additional Cu•••Cu intermolecular contacts transmitted through the hydrogen bond and π-π interactions which is described by the zJ' parameter (where z is the number of adjacent binuclear or paramagnetic species around a given binuclear unit). The calculations were based on the Heisenberg-Dirac-Van Vleck Hamiltonian in the zero field given by Equation (2).…”

Section: Magnetic Measurements and Epr Spectramentioning

confidence: 99%

“…Schiff base metal complexes are an attractive research field due to their industrial and biological applications or potential use in material science [ 1 , 2 , 3 ]. They have attracted the attention of coordination chemists and inspired them to design and synthesize mono or polynuclear complexes of transition metals [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, we report the synthesis, structure, magnetic and spectroscopic properties of two binuclear Cu(II) complexes with Schiff bases derived from 2-hydroxy-5-methylisophthalaldehyde and histamine (1) or 2-(2-aminoethyl)pyridine (2). Additionally, the role of organic ligands in the structure formation of Cu(II) Schiff bases complexes and their influence on the strength of magnetic interaction were investigated.…”

Section: Introductionmentioning

confidence: 99%

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Dinuclear Copper(II) Complexes with Schiff Bases Derived from 2-Hydroxy-5-Methylisophthalaldehyde and Histamine or 2-(2-Aminoethyl)pyridine and Their Application as Magnetic and Fluorescent Materials in Thin Film Deposition

Barwiołek

Kaczmarek‐Kędziera

Muzioł

et al. 2020

IJMS

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Two Cu(II) complexes, 1 and 2, with tridentate Schiff bases derived from 2-hydroxy-5-methylisophthalaldehyde and histamine HL1 or 2-(2-aminoethyl)pyridine HL2, respectively, were obtained and characterized by X-ray crystallography, spectroscopic (UV-vis, fluorescence, IR, and EPR), magnetic, and thermal methods. Despite the fact that the chelate formed by the NNO ligand donors (C26-C25H2-C24H2-N23=C23H-C22-C19Ph(O1)-C2(Ph)-C3H=N3-C4H2-C5H2-C6 fragment) are identical, as well as the synthesis of Cu(II) complexes (Cu:L = 2:1 molar ratio) was performed in the same manner, the structures of the complexes differ significantly. The complex 1, {[Cu2(L1)Cl2]2[CuCl4]}·2MeCN·2H2O, consists of [Cu2(L1)Cl2]+ units in which Cu(II) ions are bridged by the HL1 ligand oxygen and each of these Cu(II) ions is connected with Cu(II) ions of the next dimeric unit via two bridging Cl− ions to form a chain structure. In the dinuclear [Cu2(L2)Cl3]⋅0.5MeCN complex 2, each Cu(II) is asymmetrically bridged by the ligand oxygen and chloride anions, whereas the remaining chloride anions are apically bound to Cu(II) cations. In contrast to the complex 1, the square-pyramidal geometry of the both Cu(II) centers is strongly distorted. The magnetic study revealed that antiferromagnetic interactions in the complex 2 are much stronger than in the complex 1, which was corresponded with magneto-structural examination. Thin layers of the studied Cu(II) complexes were deposited on Si(111) by the spin coating method and studied by scanning electron microscopy (SEM/EDS), atomic force microscopy (AFM), and fluorescence spectroscopy. The Cu(II) complexes and their thin layers exhibited fluorescence between 489–509 nm and 460–464 nm for the compounds and the layers, respectively. Additionally, DFT calculations were performed to explain the structures and electronic spectral properties of the ligands.

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Section: Uv-vis and Fluorescence Spectroscopymentioning

confidence: 99%

Section: Structure Descriptionmentioning

confidence: 99%

Section: Magnetic Measurements and Epr Spectramentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dinuclear Copper(II) Complexes with Schiff Bases Derived from 2-Hydroxy-5-Methylisophthalaldehyde and Histamine or 2-(2-Aminoethyl)pyridine and Their Application as Magnetic and Fluorescent Materials in Thin Film Deposition

Barwiołek

Kaczmarek‐Kędziera

Muzioł

et al. 2020

IJMS

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Two new Cu (II) complexes based on 5‐fluorouracil‐1‐yl acetic acid and N‐donor ligands: Investigation of their interaction with DNA and anticancer activity

Yan

Bigdeli

et al. 2021

Applied Organom Chemis

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Two new Cu (II) complexes [Cu (bpy) 2 L1] BF 4 .CH 3 OH (Z 3 ) and [Cu (phen) 2 L1] BF 4 ÁH 2 O (Z9), L1 = 5-Fluorouracil-1-yl Acetic Acid, were synthesized based on 5-Fluorouracil-1-yl Acetic Acid and 2,2 0 -Bipyridine or 1,10-phenanthroline ligands and their anticancer activity toward human cancer cell lines investigated. The complexes were characterized by infrared (IR) spectra, elemental analysis, and X-ray crystallography. The interaction of the complexes with CT-DNA was investigated by UV-vis absorption and fluorescence spectroscopies, and cyclic voltammetry; cell viability (%) was studied using the absorbance amount of the samples. The interaction mode of the complexes with DNA is electrostatic, and the complexes displayed good anticancer activity against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with best IC 50 amount of 11.31 ± 0.74 μM for Z9. The results showed that the nature of the nitrogendonor ligand is very effective in the anticancer activity of the complexes.

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Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

et al. 2022

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Although it is known that the first case of cancer was recorded in ancient Egypt around 1600 BC, it was not until 1917 during the First World War and the development of mustard gas that chemotherapy against cancer became relevant; however, its properties were not recognised until 1946 to later be used in patients. In this sense, the use of metallopharmaceuticals in cancer therapy was extensively explored until the 1960s with the discovery of cisplatin and its anticancer activity. From that date to the present, the search for more effective, more selective metallodrugs with fewer side effects has been an area of continuous exploration. Efforts have led to considering a wide variety of metals from the periodic table, mainly from the d-block, as well as a wide variety of organic ligands, preferably with proven biological activity. In this sense, various research groups have found an ideal binder in Schiff bases, since their raw materials are easily accessible, their synthesis conditions are friendly and their denticity can be manipulated. Therefore, in this review, we have explored the anticancer and antitumor activity reported in the literature for coordination complexes of d-block metals coordinated with tridentate Schiff bases (O N O and O N N) derived from salicylaldehyde. For this work, we have used the main scientific databases CCDC® and SciFinder®.

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Anticancer properties, apoptosis and catecholase mimic activities of dinuclear cobalt(II) and copper(II) Schiff base complexes

Cited by 48 publications

References 84 publications

Dinuclear Copper(II) Complexes with Schiff Bases Derived from 2-Hydroxy-5-Methylisophthalaldehyde and Histamine or 2-(2-Aminoethyl)pyridine and Their Application as Magnetic and Fluorescent Materials in Thin Film Deposition

Dinuclear Copper(II) Complexes with Schiff Bases Derived from 2-Hydroxy-5-Methylisophthalaldehyde and Histamine or 2-(2-Aminoethyl)pyridine and Their Application as Magnetic and Fluorescent Materials in Thin Film Deposition

Two new Cu (II) complexes based on 5‐fluorouracil‐1‐yl acetic acid and N‐donor ligands: Investigation of their interaction with DNA and anticancer activity

Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity

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