Anticancer potential of zinc oxide nanoparticles against cervical carcinoma cells synthesized via biogenic route using aqueous extract of Gracilaria edulis

Asik, Rajmohamed Mohamed; Balakrishnan, Ganesh; Jaabir, Mohamed; Archunan, Govindaraju; Suganthy, Natarajan

doi:10.1016/j.msec.2019.109840

Cited by 50 publications

(2 citation statements)

References 48 publications

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“…Among these, it is generally believed that ROS generation is the main cause of eukaryotic cell death. [103][104][105][106] ZnO-NPs internalized by cells may enter the mitochondria and generate excessive intracellular ROS through depolarization of mitochondrial membrane and impairing the electron transport chain. These ROS may cause oxidative stress and directly destroy the membranes of the mitochondria and other organelles to induce apoptosis.…”

Section: Toxicity and Anticancer Properties Toxicity Mechanisms And Rmentioning

confidence: 99%

Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review

Li¹,

Yang²,

Qing³

et al. 2020

IJN

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Prosthesis-associated infections and aseptic loosening are major causes of implant failure. There is an urgent need to improve the antibacterial ability and osseointegration of orthopedic implants. Zinc oxide nanoparticles (ZnO-NPs) are a common type of zinccontaining metal oxide nanoparticles that have been widely studied in many fields, such as food packaging, pollution treatment, and biomedicine. The ZnO-NPs have low toxicity and good biological functions, as well as antibacterial, anticancer, and osteogenic capabilities. Furthermore, ZnO-NPs can be easily obtained through various methods. Among them, green preparation methods can improve the bioactivity of ZnO-NPs and strengthen their potential application in the biological field. This review discusses the antibacterial abilities of ZnO-NPs, including mechanisms and influencing factors. The toxicity and shortcomings of anticancer applications are summarized. Furthermore, osteogenic mechanisms and synergy with other materials are introduced. Green preparation methods are also briefly reviewed.

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Section: Toxicity and Anticancer Properties Toxicity Mechanisms And Rmentioning

confidence: 99%

Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review

Li¹,

Yang²,

Qing³

et al. 2020

IJN

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“…ZnO NPs synthesis using algae can be done through the extracellular synthesis approach. A study conducted by R. et al used Gracilaria edulis to synthesize the ZnO NPs using the extracellular approach [257]. The characterization of the ZnO NPs was done by using UV-Visible spectroscopy, FESEM, EDX, HRTEM, and FTIR.…”

Section: Biogenic Synthesis Of Zn Nps and Zno Nps Using Algae Strainsmentioning

confidence: 99%

A comprehensive review on biogenically synthesized inorganic nanoparticles and their applications in anticancer activities

Barreto,

Fatima,

Tariq

et al. 2023

BAB

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The progression in nanotechnology has revolutionized the biomedical sciences for diagnosis and treatment of diseases like cancer. There have been many kinds of nanomaterials but Inorganic nanomaterials have been considered potential candidates for anticancer activities due to their high biocompatibility, less toxicity, high stability, and high precision in targeting affected cells. Several synthesis approaches have been used to prepared these nanoparticles, such as physical, chemical, and biogenic methods. Due to higher toxicity and adverse effects of chemical methods, eco-friendly way such as biosynthesized inorganic nanomaterials have attained much attention for multiple application particularly treatment of diseases. This review presents a comprehensive and updated knowledge (2015-2023) regarding the cancer treatment. The article first categorizes biogenically synthesized inorganic nanoparticles into three main groups: metallic nanoparticles, metal oxide nanoparticles, and quantum dots and then successful stories related to cancer treatment. This will also provide very effective platform for researchers and academia to detail the biogenically synthesized inorganic nanoparticles’ morphology, their characterization, targeted cancer cells.

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Biological synthesis of manganese oxide nanoparticles from aerial parts of Prunus dulcis and their in vitro investigation of medical properties

Aarthi,

Anitha

2023

Applied Organom Chemis

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The field of functional nanohybrid material is an emerging research area in material science due to its vast range of applications. The use of novel technology and innovative therapeutics has led to potent applications, including controlling the size of nanoparticles (NPs). This has resulted in a novel report on the synthesis of manganese oxide NPs using aerial parts of queen of roses Prunus dulcis (almond) leaves, seed, and seed oil (using Clevenger apparatus), which functions as a reducing agent. Manganese sulfate was used as a precursor in the synthesis process. The synthesized nanohybrid Mn3O4 NPs were studied using different characteristics techniques such as X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and energy‐dispersive X‐ray spectroscopy (EDX). The photoluminescence spectra display the blue emission ranging from 483.2 to 486.5 nm. The biosynthesized Mn3O4 NPs were tested for bactericidal activity and showed tremendous inhibition against gram‐positive and gram‐negative bacteria. The antioxidant activity of Mn3O4 NPs was enhanced using 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) assay, which revealed the higher activity of Mn3O4 NPs from P. dulcis leaf extract. In vitro cytotoxicity of hybrid Mn3O4 NPs was examined using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay against cervical cancer (HeLa cell line) with different concentrations. The results showed an IC50 value of 61.97 μg mL−1 for Mn3O4 NPs from P. dulcis leaf extract. In general, the phytosynthetic route with synergistic effect of nanohybrid demonstrated an interaction with cancer cells, highlighting a pioneering optimum approach in synthesis of Mn3O4 NPs from aerial parts of P. dulcis.

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Anticancer potential of zinc oxide nanoparticles against cervical carcinoma cells synthesized via biogenic route using aqueous extract of Gracilaria edulis

Cited by 50 publications

References 48 publications

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

<p>Enhancing ZnO-NP Antibacterial and Osteogenesis Properties in Orthopedic Applications: A Review</p>

A comprehensive review on biogenically synthesized inorganic nanoparticles and their applications in anticancer activities

Biological synthesis of manganese oxide nanoparticles from aerial parts of Prunus dulcis and their in vitro investigation of medical properties

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