Anticancer potential of indirubins in medicinal chemistry: Biological activity, structural modification, and structure-activity relationship

Wang, Hezhen; Wang, Zhiyuan; Wei, Chunyong; Wang, Jing; Xu, Yingshu; Bai, Guohui; Yao, Qizheng; Zhang, Lei; Chen, Yongzheng

doi:10.1016/j.ejmech.2021.113652

Cited by 34 publications

(29 citation statements)

References 143 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 5 A comprehensive review and meta-analysis related to anticancer applications was recently published and demonstrates the potential for the development of selective indirubin moieties. 6 Beyond medical applications, indirubin was recently shown to exhibit photoswitching behavior with red light, which is enhanced when stabilized by supramolecular interactions with a thiourea additive thus commencing a new line of inquiry for this molecule. 7 …”

Section: Introductionmentioning

confidence: 99%

A tunable synthesis of indigoids: targeting indirubin through temperature

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

A tunable synthesis of indigoids: targeting indirubin through temperature

et al. 2022

View full text Add to dashboard Cite

show abstract

“…), marine mollusks and bacteria [ 106 , 107 ]. It has been identified that indirubins are potent ATP-competitive inhibitors of protein kinases (CDKs) and glycogen synthase kinase 3 (GSK-3β) [ 108 ]. In addition, it has been shown that 6-substituted indirubin derivatives could inhibit both leishmanial cyclin-dependent kinase 1 (CDK1) homologs, cdc2-related protein kinase 3 (LCRK3) and glycogen synthase kinase 3 (LGSK-3), two enzymes essential for parasite viability [ 109 ].…”

Section: Recent Development Of Indole-based Small Molecules Targeting Malaria Trypanosomiasis and Leishmaniasismentioning

confidence: 99%

Recent Progress in the Development of Indole-Based Compounds Active against Malaria, Trypanosomiasis and Leishmaniasis

Pacheco

Santos

2022

Molecules

View full text Add to dashboard Cite

Human protozoan diseases represent a serious health problem worldwide, affecting mainly people in social and economic vulnerability. These diseases have attracted little investment in drug discovery, which is reflected in the limited available therapeutic arsenal. Authorized drugs present problems such as low efficacy in some stages of the disease or toxicity, which result in undesirable side effects and treatment abandonment. Moreover, the emergence of drug-resistant parasite strains makes necessary an even greater effort to develop safe and effective antiparasitic agents. Among the chemotypes investigated for parasitic diseases, the indole nucleus has emerged as a privileged molecular scaffold for the generation of new drug candidates. In this review, the authors provide an overview of the indole-based compounds developed against important parasitic diseases, namely malaria, trypanosomiasis and leishmaniasis, by focusing on the design, optimization and synthesis of the most relevant synthetic indole scaffolds recently reported.

show abstract

“…14 Similar to bioactive plant constituent artemisinin, indirubin (Fig. 1A) is also the active plant ingredient of indigo naturalis (named Sei Tai in Japanese or Qing Dai in Chinese, a dark blue powder prepared from the leaves and branches of various indigo-producing plants) 17,19–27 and Danggui Luhui Wan (a TCM formulation in the treatment of various chronic diseases such as cancer and inflammation, and composed of 11 medicinal herbs including indigo naturalis, etc. ).…”

Section: Introductionmentioning

confidence: 99%