Anticancer pH-Responsive Supramolecular Vesicles Fabricated Using Water-Soluble Pillar[5]arene and Curcumin Derivative

Zhang, Wang; Yang, Jinliang; Li, Xusen; Chen, Tianyu; Park, Sumin; Bae, Minjun; Jung, Dayun; Lin, Liwei; Paek, Sun Ha; Piao, Yuanzhe

doi:10.1016/j.matdes.2022.111084

Cited by 9 publications

(5 citation statements)

References 41 publications

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“…The product was then rotary-evaporated using pressure distillation. At last, it was dried in a vacuum oven at 70 °C for 30 h. The saturated solubility of samples in water was measured at 25 °C in accordance with a previously reported approach [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Supramolecular Design Strategy of a Water-Soluble Diphenylguanidine-Cyclodextrin Polymer Inclusion Complex

Guo

Lin²,

Wang³

et al. 2022

Molecules

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Diphenylguanidine (DPG) is a widely used secondary accelerator for the vulcanization of natural rubber (NR) latex. However, its low water solubility and high toxicity limit its use in high-end NR products. In this study, a water-soluble inclusion complex of DPG and a β-cyclodextrin polymer (β-CDP), termed DPG-β-CDP, was prepared through supramolecular interactions and characterized using Fourier-transform infrared spectroscopy, 1H NMR, scanning electron microscopy, and UV-vis spectroscopy techniques. In comparison with that of DPG, the water solubility of DPG-β-CDP was greatly enhanced because of the water-soluble host molecule. The molar ratio of DPG to the CD unit in β-CDP was determined to be 1:1. At 25 °C, the binding constant of DPG-β-CDP was found to be 9.2 × 105 L/mol by UV-vis spectroscopy. The proposed method for forming inclusion complexes with high potential for use as water-soluble vulcanization accelerators is promising.

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Section: Methodsmentioning

confidence: 99%

Supramolecular Design Strategy of a Water-Soluble Diphenylguanidine-Cyclodextrin Polymer Inclusion Complex

Guo

Lin²,

Wang³

et al. 2022

Molecules

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“…Demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are natural analogs of curcumin that lack one or two methoxyl groups on the benzene ring of the parent structure, providing better stability and outstanding anti-inflammatory and antiviral properties [ 119 , 120 ]. However, their low water solubility and stability lead to poor bioavailability and limited clinical efficacy.…”

Section: Preparation and Antimicrobial Properties Of Ss Antimicrobial...mentioning

confidence: 99%

“…Cross-linked SS impedes the release of curcumin into the culture medium. Additionally, Chuysinuan et al [60] reported that the CMC/SS dressing, as an effective drug delivery device, can release curcumin from the dressing in a controlled-release manner within 48 h, with an initial burst release rate of up to 40% after the first hour and a gradual release rate of 60-80% after 24 h. Demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) are natural analogs of curcumin that lack one or two methoxyl groups on the benzene ring of the parent structure, providing better stability and outstanding anti-inflammatory and antiviral properties [119,120]. However, their low water solubility and stability lead to poor bioavailability and limited clinical efficacy.…”

Section: Ss Composites Loaded With Plant Extractsmentioning

confidence: 99%

Silk Sericin and Its Composite Materials with Antibacterial Properties to Enhance Wound Healing: A Review

Wang,

Zhuo,

Fang

et al. 2024

Biomolecules

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Wound infections may disrupt the normal wound-healing process. Large amounts of antibiotics are frequently used to prevent pathogenic infections; however, this can lead to resistance development. Biomaterials possessing antimicrobial properties have promising applications for reducing antibiotic usage and promoting wound healing. Silk sericin (SS) has been increasingly explored for skin wound healing applications owing to its excellent biocompatibility and antioxidant, antimicrobial, and ultraviolet-resistant properties. In recent years, SS-based composite biomaterials with a broader antimicrobial spectrum have been extensively investigated and demonstrated favorable efficacy in promoting wound healing. This review summarizes various antimicrobial agents, including metal nanoparticles, natural extracts, and antibiotics, that have been incorporated into SS composites for wound healing and elucidates their mechanisms of action. It has been revealed that SS-based biomaterials can achieve sustained antimicrobial activity by slow-release-loaded antimicrobial agents. The antimicrobial-loaded SS composites may promote wound healing through anti-infection, anti-inflammation, hemostasis, angiogenesis, and collagen deposition. The manufacturing methods, benefits, and limitations of antimicrobial-loaded SS materials are briefly discussed. This review aims to enhance the understanding of new advances and directions in SS-based antimicrobial composites and guide future biomedical research.

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“…[9]] Macrocycles such as crown ethers, cyclodextrins, calixarenes, pillararenes, and cucurbiturils have been successfully used to form ICs. [10,11] Among the macrocycles, cyclodextrins (CDs) are undoubtedly the most extensively used in biomedical and pharmaceutical applications. [12][13][14] More than 40 formulations containing native or modified CDs are currently marketed for diverse therapeutic purposes.…”

Section: Introductionmentioning

confidence: 99%

“…In this area, the macrocycles are systematically used as hosts to form ICs, [8] since they yield key benefits like suitable drug‐loading proficiency, stability enhancement, and feasible derivatization. [9]] Macrocycles such as crown ethers, cyclodextrins, calixarenes, pillararenes, and cucurbiturils have been successfully used to form ICs [10,11] …”

Section: Introductionmentioning

confidence: 99%

Inclusion and Non‐Inclusion Complexes between Curcumin and β‐Cyclodextrin with High‐Curcumin Loading and Enhanced Aqueous Solubility Obtained by Mechanochemistry

Cabrera‐Quiñones,

López‐Méndez,

Guadarrama

2023

ChemistrySelect

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In this study, we employ mechanochemistry as an innovative strategy, using a Planetary Mill, to obtain supramolecular structures in the solid state between Curcumin (Cur) and β‐cyclodextrin (βCD), exploring different parameters such as jars and balls material (stainless steel versus zirconium oxide), milling time, as well as the effect on imposing different Cur:βCD molar ratios. Our findings demonstrate that regardless of the milling material used, the same supramolecular interactions between Cur and βCD seem to be promoted. However, depending on the molar ratio, different supramolecular modes are produced resulting in inclusion complexes (ICs) or non‐inclusion complexes (non‐ICs) by a partial or total amorphization of both Cur and βCD. Independently of the type of supramolecular complex obtained (ICs/or non‐ICs), high content of Cur was quantified in all the systems, achieving a Cur content of up to 342 mg per mmol of βCD, along with an enhancement in Cur aqueous solubility. The Cur:βCD 1 : 2 complex showed the highest aqueous solubility (around 10‐times more soluble than milled Cur). In our conditions, the optimum time to form the supramolecular complexes was 60 min. The stability of the complexes was directly related to the extent of encapsulation of Cur inside the βCD cavity.

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Anticancer pH-Responsive Supramolecular Vesicles Fabricated Using Water-Soluble Pillar[5]arene and Curcumin Derivative

Cited by 9 publications

References 41 publications

Supramolecular Design Strategy of a Water-Soluble Diphenylguanidine-Cyclodextrin Polymer Inclusion Complex

Supramolecular Design Strategy of a Water-Soluble Diphenylguanidine-Cyclodextrin Polymer Inclusion Complex

Silk Sericin and Its Composite Materials with Antibacterial Properties to Enhance Wound Healing: A Review

Inclusion and Non‐Inclusion Complexes between Curcumin and β‐Cyclodextrin with High‐Curcumin Loading and Enhanced Aqueous Solubility Obtained by Mechanochemistry

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