Anticancer Molecules from Catharanthus roseus

Abstract

Catharanthus roseus is an important medicinal plant found in various parts of the world and the bioactive compound has been extracted and used as anticancer agent to treat the cancer over decades. However, the extraction of bioactive compound also results in the generation of large quantities of pollution with wasted solvents. Toxic pollution occurs when synthetic chemicals are discharged or natural chemicals accumulate to toxic levels in the environment, causing reductions in wildlife numbers, degrading ecosystem functions and threatening human health. This review covers the extraction and phytochemical obtained leading to chemical compounds related to anti-cancer property of C. roseus. Additionally, recent advances of using biological cell cultures were also addressed. Thus, this work can be used for further investigation of C. roseus to be undertaken in future for its anticancer property further development and efficient production in drug industry.

Improvement of Phytopharmaceutical and Alkaloid Production in Periwinkle Plants by Endophyte and Abiotic Elicitors

“…Periwinkle (Catharanthus roseus L. (G.) Don; Apocynaceae), is a significant source of high natural antioxidants and terpenoid indole alkaloids (approximately 130 TIAs) involving two essential dimeric alkaloids utilized in cancer chemotherapy [3]. The most important periwinkle alkaloids are vincristine (VCR) and vinblastine (VLB) which have been applied as a foremost active constituent of different marketable chemotherapy drugs (ONCOVIN and VELNR respectively) for chronic cancers such as leukemia, breast carcinoma, lung cancer, and Hodgkin's disease [3,4]. Formerly, they were isolated in trace amounts (0.0003% and 2.56% of dry leaf weight for VCR and VB respectively) from periwinkle leaves [5].…”

A comparative UPLC‐Q‐Orbitrap‐MS untargeted metabolomics investigation of different parts of Clausena lansium (Lour.) Skeels

“…(Zhang, Zhang, Zheng, & Tian, 2019) Vindoline, an indole alkaloid with anticancer activity, which is derived from Catharanthus roseus, was also detected. (Taher et al., 2019) Therefore, the global identification of metabolites in different parts of wampee may provide new insights for the understanding of the bioactivities of C. lansium .…”

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

“…The stem and leaves of C. roses are rich in Vinca alkaloids i.e., vincristine, vinblastine, and semi-synthetic derivatives viz. vindesine, vinorelbine, and vinflunine [ 90 , 91 ]. Vinflunine and vinorelbine have been produced to increase the therapeutic action and synthesized using the precursor alkaloids catharanthine and vindoline.…”

“…Microtubules are heterodimers made up of α-and β-tubulin that polymerize and depolymerize dynamically at their ends. Microtubules assembly and disassembly are known as ‘treadmilling’ and ‘dynamic instability, respectively, and are controlled by guanosine triphosphate and tubulin binding [ 91 ].…”