Anticancer Effect of Thymol on AGS Human Gastric Carcinoma Cells

Kang, Seo-Hee; Kim, Yon-Suk; Kim, Min Jung; Hwang, Jin-Woo; Jeong, Jae-Hyun; Dong, Xin; Lee, Jae Woong; Moon, Sang-Ho; Jeon, Byong-Tae; Park, Pyo-Jam

doi:10.4014/jmb.1506.06073

Cited by 91 publications

(61 citation statements)

References 35 publications

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“…Several studies are available for the antifungal effects that could explained our results, and for A. abrotanum, the plant showed that activity against C. albicans [19]. These effects could be due to the active constituents that in the essential oil of the plant which they have an antifungal action such as borneol [20] and camphor [21], which may be explained the results in this work.…”

Section: Resultssupporting

confidence: 49%

The Evaluation of Antimicrobial and Cytotoxic Activity of the Essential Oil Extracted From the Aerial Parts of Southernwood Herb (Artemisia Abrotanum L.) That Recently Grown in Iraq

Almahdawy

Said

Abbas

et al. 2017

Asian J Pharm Clin Res

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Objective: This research is to study the assessment of the antimicrobial and cytotoxic activity of the essential oil extracted from the aerial parts of Artemisia abrotanum L. that recently grown in Iraq. Methods:The essential oil of A. abrotanum was extracted by hydrodistillation using Clevenger apparatus. This essential oil was tested for antimicrobial activity of five different pathogenic microorganisms (Gram-positive [Staphylococcus aureus and Bacillus subtilis] and Gram-negative [Salmonella typhi and Escherichia coli] bacterial strains) and fungi: Candida albicans using diffusion well agar method. Furthermore, this essential oil was tested for cytotoxic activity using rhabdomyosarcoma cell line, and the growth or inhibition of cancer cells was measured by MTT method. Results:The obtained results show that the antibacterial activity for A. abrotanum against S. aureus was at concentrations 40, 25, and15 µl with minimum inhibitory concentrations of 20 mm, while it showed antibacterial activity against E. coli for four different concentrations of 40, 25, 15, and10 μl with inhibition zone of 16, 12, 14, and 10 mm, respectively, and it showed antifungal activity against C. albicans at four concentrations 40, 25, 15, and10 μl with inhibition zone of 18, 24, 26, and 30 mm, respectively. The cytotoxic activity of the extracted essential oil was showed that the three concentrations of the extract (25, 50, and 100 μg/ml) were all lower significantly as compared to dimethyl sulfoxide group. A significant difference was seen for group 25 with both groups 50 and 100, but no significant difference was seen between the two later. Finally, the antimicrobial and anticancer activity of this plant could be due to its essential oil constituents: Borneol, cymene, camphor, terpineol, eucalyptol, and aromadendrene. Conclusion:The essential oil of A. abrotanum L. has a potent antimicrobial and anticancer effect against the tested microbial organisms and the cancer cells.

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Section: Resultssupporting

confidence: 49%

The Evaluation of Antimicrobial and Cytotoxic Activity of the Essential Oil Extracted From the Aerial Parts of Southernwood Herb (Artemisia Abrotanum L.) That Recently Grown in Iraq

Almahdawy

Said

Abbas

et al. 2017

Asian J Pharm Clin Res

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“…The beneficial effects in these cells were attributed to the generation of intracellular ROS, depolarization of mitochondrial membrane potential, apoptosis and impeding cell growth via intrinsic mitochondrial pathway and the activation of pro-apoptotic mitochondrial proteins; caspases, Bax and PARP (Kang et al, 2016). …”

Section: Thymol In Cancer Cellsmentioning

confidence: 99%

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

et al. 2017

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Thymol, chemically known as 2-isopropyl-5-methylphenol is a colorless crystalline monoterpene phenol. It is one of the most important dietary constituents in thyme species. For centuries, it has been used in traditional medicine and has been shown to possess various pharmacological properties including antioxidant, free radical scavenging, anti-inflammatory, analgesic, antispasmodic, antibacterial, antifungal, antiseptic and antitumor activities. The present article presents a detailed review of the scientific literature which reveals the pharmacological properties of thymol and its multiple therapeutic actions against various cardiovascular, neurological, rheumatological, gastrointestinal, metabolic and malignant diseases at both biochemical and molecular levels. The noteworthy effects of thymol are largely attributed to its anti-inflammatory (via inhibiting recruitment of cytokines and chemokines), antioxidant (via scavenging of free radicals, enhancing the endogenous enzymatic and non-enzymatic antioxidants and chelation of metal ions), antihyperlipidemic (via increasing the levels of high density lipoprotein cholesterol and decreasing the levels of low density lipoprotein cholesterol and low density lipoprotein cholesterol in the circulation and membrane stabilization) (via maintaining ionic homeostasis) effects. This review presents an overview of the current in vitro and in vivo data supporting thymol’s therapeutic activity and the challenges concerning its use for prevention and its therapeutic value as a dietary supplement or as a pharmacological agent or as an adjuvant along with current therapeutic agents for the treatment of various diseases. It is one of the potential candidates of natural origin that has shown promising therapeutic potential, pharmacological properties and molecular mechanisms as well as pharmacokinetic properties for the pharmaceutical development of thymol.

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“…In this study, three kinds of monoterpenes: thymol, linalool, and menthol, were and menthol exhibited anti-cancer effects against human tumor cell lines, such as prostate cancer [19,20], malignant melanoma [21], colon cancer [22], and gastric cancer [23]. They suppressed cell growth and induced apoptosis in tumor cells in a time-and dose-dependent manner.…”

Section: Discussionmentioning

confidence: 98%

In vitro analysis of radioprotective effect of monoterpenes

Kudo

Hanafusa

Ono

2017

J Radioanal Nucl Chem

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Monoterpenes are naturally occurring hydrocarbons composed of two units of isoprenes.They exhibit antioxidant activity to scavenge reactive oxygen species, such as hydroxyl radicals. We investigated the potential of monoterpenes such as thymol, linalool, and menthol to act as radioprotectants. The proliferation of EL4 cells, a mouse lymphoma cell line, treated with linalool at a concentration of 500 μM or more was not affected by X-ray irradiation. Plasmid-nicking assay performed using formamidopyrimidine-DNA glycosylase showed that linalool prevented single strand breaks and oxidized purines on pUC19 plasmid DNA. These findings indicate that linalool has the ability to scavenge reactive oxygen species and is a potential radioprotector.

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Anticancer Effect of Thymol on AGS Human Gastric Carcinoma Cells

Cited by 91 publications

References 35 publications

The Evaluation of Antimicrobial and Cytotoxic Activity of the Essential Oil Extracted From the Aerial Parts of Southernwood Herb (Artemisia Abrotanum L.) That Recently Grown in Iraq

The Evaluation of Antimicrobial and Cytotoxic Activity of the Essential Oil Extracted From the Aerial Parts of Southernwood Herb (Artemisia Abrotanum L.) That Recently Grown in Iraq

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

In vitro analysis of radioprotective effect of monoterpenes

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