Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823

Liu, Wei; Guo, Qinglong; Qin, You; Zhao, Li; Gu, Hong-Yan; Yuan, Shengtao

doi:10.3748/wjg.v11.i24.3655

Cited by 109 publications

(73 citation statements)

References 13 publications

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“…Apoptosis is one of the main cytotoxicity mechanisms of prenylated caged xanthones studied in several cancer cells. The growth inhibition of gambogic acid on human gastric carcinoma MGC-803 , BGC-823 (Liu et al, 2005), human malignant melanoma A375 cells , KKU-100 and KKU-M156 cells (Hahnvajanawong et al, 2010) was related to the apoptosis induction of which the molecular mechanism is the regulation of gene Bcl-2, an apoptosis inhibitor and Bax, an apoptosis inducer. Gambogic acid could downregulate the expression of Bcl-2 mRNA and upregulate the expression of Bax mRNA.…”

Section: Pharmaceutical Biologymentioning

confidence: 99%

Prenylated caged xanthones: Chemistry and biology

Anantachoke

Tuchinda

Kuhakarn

et al. 2011

Pharmaceutical Biology

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Section: Pharmaceutical Biologymentioning

confidence: 99%

Prenylated caged xanthones: Chemistry and biology

Anantachoke

Tuchinda

Kuhakarn

et al. 2011

Pharmaceutical Biology

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“…Animal Studies HepG2 cells (5 Â 10 6 ) were implanted subcutaneously in the right flank region of BALB/cA nude mice following protocols described in the literature (30). Briefly, when tumor size increased to 100 to 200 mm 3 , the mice were randomly divided into four groups consisting of equal numbers (six) of animals.…”

Section: Plasmids and Transfectionmentioning

confidence: 99%

Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells

Wang

Rao

et al. 2008

Molecular Cancer Therapeutics

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“…The day of first treatment was set as day 1. The size of the tumors was assessed every other day, and tumor volume was determined using the following equation: Tumor volume (mm 3 ) = (a x b 2 ) / 2 (where a and b refer to the longest and shortest dimension in mm, respectively) (12). The animals were weighed, and food and water intake was measured daily.…”

Section: Experimental Allografts Of Ham-1 In Hamstersmentioning

confidence: 99%

“…Gambogic acid, forbesione, isomorellin and isomorellinol, the caged xanthones isolated from G. hanburyi, are reported to exhibit antitumor activities (8) and cytotoxic effects in several cancer cell lines (8)(9)(10). Gambogic acid is the most intensively studied caged xanthone, and exhibits potent antitumor activity in vitro and in vivo (11)(12)(13) through several mechanisms, including inhibition of topoisomerase II alpha activity (14), downregulation of telomerase (15), induction of cell cycle arrest (16) and induction of apoptosis (17). Due to its low toxicity against normal tissues (18,19), gambogic acid is now approved for a phase II clinical trial in China (20).…”

Section: Introductionmentioning

confidence: 99%

Antitumor effect of forbesione isolated from Garcinia hanburyi on cholangiocarcinoma in vitro and in vivo

et al. 2016

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Abstract. Cholangiocarcinoma (CCA) is a malignancy with no effective therapy and poor prognosis. Forbesione, a caged xanthone isolated from Garcinia hanburyi, has been reported to inhibit proliferation and to induce apoptosis in human CCA cell lines. The present study aimed to further explore the potential anticancer properties of forbesione by testing its effects against the hamster CCA cell line Ham-1 in vitro and in vivo. It was observed that forbesione inhibited the growth of Ham-1 cells in vitro and suppressed Ham-1 growth as allograft in hamsters by inducing cell cycle arrest at the S phase. This was mediated by decreasing the protein expression of cyclin E, cyclin A and cyclin-dependent kinase 2. In addition, increased expression of p21 and p27 was detected, which could possibly explain the reduced expression of proliferating cell nuclear antigen and of the bile duct cell marker cytokeratin 19 observed in forbesione-treated Ham-1 cells in vitro and in tumor tissues of forbesione-treated hamsters. Furthermore, forbesione induced apoptosis through multiple pathways. The death receptor pathway was activated by increased expression of Fas, Fas-associated death domain and activated caspase-3, along with decreased expression of procaspase-8 and procaspase-3. The mitochondrial pathway was driven by increased expression of B-cell lymphoma (Bcl)-2-like protein 4, activated caspase-9 and inhibitor of κB-α, along with decreased expression of Bcl-2, survivin, procaspase-9 and nuclear factor-κB/p65. The endoplasmic reticulum pathway was stimulated by increased expression of activated caspase-12 and decreased expression of procaspase-12. No side effects or toxicity were observed in forbesione-treated hamsters. Thus, forbesione is a potential drug candidate for cancer therapy that deserves further investigation. IntroductionCholangiocarcinoma (CCA), the malignant tumor of biliary epithelial cells, is the cancer of highest incidence in northeastern Thailand (1), and has increasing incidence and mortality worldwide (2,3). More than 70% of CCA patients have an advanced stage of the disease at the time of diagnosis, which makes curative surgical resection unfeasible (4). In these advanced CCA patients, chemotherapy is the usual treatment option (5). The systemic chemotherapy choices currently offered are 5-fluorouracil (5-FU), carboplatin plus 5-FU, gemcitabine and paclitaxel, which have failed to improve survival, and response rates are only ~20% (4). New therapeutic agents for CCA are urgently required.In the past few decades, natural bioactive substances derived from plants have been considered as important antitumor drug sources (6). Forbesione is a caged xanthone isolated from the resin and fruits of Garcinia hanburyi Hook. f. (family Guttiferae), which have been used in Thai traditional medicine (6,7). Gambogic acid, forbesione, isomorellin and isomorellinol, the caged xanthones isolated from G. hanburyi, are reported to exhibit antitumor activities (8) and cytotoxic effects in several cancer cell lines (8-10). Gambog...

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Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823

Cited by 109 publications

References 13 publications

Prenylated caged xanthones: Chemistry and biology

Prenylated caged xanthones: Chemistry and biology

Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells

Antitumor effect of forbesione isolated from Garcinia hanburyi on cholangiocarcinoma in vitro and in vivo

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