Anticancer applications of phytochemicals in gastric cancer: Effects and molecular mechanism

Abstract

Gastric cancer (GC) is the fourth most common malignant cancer and is a life-threatening disease worldwide. Phytochemicals have been shown to be a rational, safe, non-toxic, and very promising approach to the prevention and treatment of cancer. It has been found that phytochemicals have protective effects against GC through inhibiting cell proliferation, inducing apoptosis and autophagy, suppressing cell invasion and migration, anti-angiogenesis, inhibit Helicobacter pylori infection, regulating the microenvironment. In recent years, the role of phytochemicals in the occurrence, development, drug resistance and prognosis of GC has attracted more and more attention. In order to better understand the relationship between phytochemicals and gastric cancer, we briefly summarize the roles and functions of phytochemicals in GC tumorigenesis, development and prognosis. This review will probably help guide the public to prevent the occurrence and development of GC through phytochemicals, and develop functional foods or drugs for the prevention and treatment of gastric cancer.

Mechanistic inhibition of gastric cancer-associated bacteria Helicobacter pylori by selected phytocompounds: A new cutting-edge computational approach

“…Accumulated evidence and epidemiological investigations have reflected that natural product, including phytochemicals, have been explored potentially for the prevention and treatment of cancers and found to be useful in developing drugs and medicines counteracting and managing cancers, including gastric cancer caused by H. pylori infection [ [17] , [19] , [20] , [83] ]. Notably, various studies have suggested that mentioned bioactive phytochemical components with structural stability, potential bioavailability, and bioactivity could play a crucial role in formulating novel treatment regimens for gastric cancer management while minimizing the adverse effects associated with chemotherapeutic drugs as well as being comparatively safer.…”

Anticancer Mechanism of Astragalus Polysaccharide and Its Application in Cancer Immunotherapy

“…Polysaccharides, especially those derived from fungi, algae, tea, APS, Dendrobium, and other edible plants and herbs, are recognized for their anticancer properties against GC [62]. The anti-GC effects of APS are manifested not only in the enhancement of immune activity and the direct inhibition of tumor cell proliferation but also in the alleviation of adverse reactions to anticancer drugs [57,68,170,[185][186][187][188][189].…”

Recent Developments in Nanoparticle Formulations for Resveratrol Encapsulation as an Anticancer Agent

“…A notable statistic underscores the significance of natural origins, indicating that 51% of the 1211 newly approved small-molecule drugs worldwide between 1981 and 2014 were derived from natural products [ 20 ]. Polyphenols have been known to have various preventive effects on different conditions such as diabetes, cardiovascular disease, neurodegenerative disorder, and obesity [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ], and have been extensively studied to determine their anticancer potential and incorporate them into cancer treatment modalities like chemotherapy and targeted therapy [ 30 , 31 , 32 , 33 ].…”