Anticancer and antioxidant effects of red cabbage on three cancerous cell lines and comparison with a normal cell line (HFF-3)

Tajalli, Faezeh; Saeedi, Mansour; Malekabadi, Atena Vafaei

doi:10.15562/gnc.73

Cited by 13 publications

(6 citation statements)

References 13 publications

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“…Purple vegetables, including purple-leaved sweet potato, heartleaf houttuynia, purple-leaved perilla line 1, and bicolored-leaved perilla line 2, can protect lymphocyte DNA against oxidative damage due to their strong antioxidant activities [16]. A study showed that red kale extracts at a concentration of 2500 µg/mL were effective in inhibiting cancer cell growth and increasing the death rate of cancer cells [17]. More than 20 naturally occurring anthocyanins have been identified, and only six are commonly found in higher plants: cyanidin, delphinidin, pelargonidin, peonidin, petunidin, and malvidin [18].…”

Section: Introductionmentioning

confidence: 99%

Development of Novel Markers and Creation of Non-Anthocyanin and Anthocyanin-Rich Broccoli (Brassica oleracea var. italica) Cultivars

Liu

Yao

et al. 2022

Applied Sciences

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In broccoli, anthocyanin pigments can be accumulated in the flower bud epidermis, resulting in a purple-green head. This study aimed to create non-anthocyanin green broccoli varieties and anthocyanin-rich purple broccoli varieties using new F3′H and Pur7.1-K1 molecular markers, respectively. The breeding program started with crosses of the recipient (superior variety and line) LF02 line with the donor line SN60 carrying the recessive allele f3′h and the donor line BT126 carrying the dominant allele Pur7.1. The F1 hybrids were confirmed with molecular markers and backcrossed with the recurrent parent LF02, followed by cycles of foreground and background selection at each stage. A total of 161 green plants with the f3′hf3′h genotype and 152 purple plants with the Pur7.1Pur7.1 genotype were selected from the BC3F2 line. Among these, 34 green plants and 28 purple plants demonstrated >85% background recovery. The identified plants were selfed to obtain 301 green and 416 purple BC3F3 plants for assessment of major agronomic traits. After these investigations, two green broccoli lines without anthocyanin and three anthocyanin-rich purple lines with the best yield/quality characteristics were obtained. The development of these lines might help provide basic materials and the theoretical basis for breeding commercial broccoli varieties.

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Section: Introductionmentioning

confidence: 99%

Development of Novel Markers and Creation of Non-Anthocyanin and Anthocyanin-Rich Broccoli (Brassica oleracea var. italica) Cultivars

Liu

Yao

et al. 2022

Applied Sciences

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“…Although further investigations are needed, the present study sheds light on the possible anticancer activity of kale and wild cabbage extracts. There are several reports on the cytotoxic effect of cabbages [ 44 , 45 ], broccoli [ 46 , 47 ], and curly kales [ 48 , 49 , 50 ] linked to the richness in polyphenolic compounds and antioxidant activity. There is only rare evidence of anticancer activity of wild Brassica species [ 6 ] and flat-leaved kale [ 36 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Antiproliferative Activities of Kale (Brassica oleracea L. Var. acephala DC.) and Wild Cabbage (Brassica incana Ten.) Polyphenolic Extracts

et al. 2023

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Brassicaceae are rich in healthy phytochemicals that have a positive impact on human health. The aim of this study was to analyze the phenolic compounds and antioxidant and anticancer potential of traditional Croatian kale (Brassica oleracea L. var. acephala DC.) and wild cabbage (Brassica incana Ten.) extracts. The phenolic groups and antioxidant activity were determined by spectrophotometry, selected phenolic compounds (ferulic acid, sinapic acid, salicylic acid, kaempferol, and quercetin) were analyzed by LC-MS/MS, and anticancer potential was evaluated in vitro using HeLa cells. The extracts of both plant species are rich in phenolic compounds and showed significant antioxidant activity at similar levels. LC-MS/MS detected sinapic acid as the most abundant phenolic acid, followed by ferulic acid, while salicylic acid was present at lower concentrations. A comparative analysis showed that wild cabbage contained significantly more sinapic acid, while kale contained more kaempferol and quercetin. Both Brassica extracts at a concentration of 50 µg mL−1 showed an antiproliferative effect on HeLa cells, while they did not affect the proliferation of normal human skin fibroblasts. Wild cabbage extract also showed an antiproliferative effect on HeLa cells at a lower applied concentration of 10 µg mL−1 of extracts. The clonogenic analysis also revealed the inhibitory effect of the extracts on HeLa colony growth.

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“…The prepared concentrations in the study ranged from 625-20000 µg/mL, and the study showed the presence of anti-cancer activity for the studied cancerous cell lines, especially at higher doses. Red cabbage extract also decreased the cell viability of HFF-3 normal cells (IC 50 = 6.4 mg/mL) thus red cabbage extract should not be used at higher concentration than 6.4 mg/mL to avoid normal cell damage (Tajalli et al, 2020).…”

Section: Cytotoxic Activitymentioning

confidence: 99%

Investigation of Antimicrobial, DNA Protective and Cytotoxic Activity of Red Cabbage (Brassica Oleracea L. Var. Capitata F. Rubra) Plant

ALANI

Özaslan

Karagöz

et al. 2021

EPSTEM

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The need to search for natural products that offer a safe alternative to drugs and industrial products that often cause side effects and harm human health is growing over the years. In this study, the water and methanol extracts of the anthocyanin-rich red cabbage (Brassica oleracea L. var. capitata f. rubra) which is available on markets throughout the year, were examined for their antibacterial activity on Escherichia coli, Staphylococcus aereus and Stenotrophomonas maltophilia, and for their antifungal activity on Yarrowia lipolytica, Candida albicans and Candida maltophilia. The DNA protective activity of extracts on the pBR322 plasmid was evaluated by exposing pBR322 to UV and adding hydrogen peroxide. Furthermore, the MTT assay was performed on the H1299 lung cancer cell line and the HUVEC cell line as a negative control to evaluate the cytotoxicity of the extracts. The red cabbage extracts were found to have no antibacterial or antifungal activity on the tested microorganisms. The results of DNA protective activity have shown that at a concentration of 50 mg/mL there is a DNA protective activity of the extracts. No effect of the red cabbage extracts on the H1299 cell line as shown by MTT assay results. On the other hand, the decrease in the viability of HUVEC cells started at a concentration of 25 μg/mL and above, reaching 70% at 100 μg/ mL for the water extract and 74 % at 100 μg/ mL for the methanol extract. Further studies to investigate the active components of the DNA protective activity in the red cabbage extracts are required. Further studies are also needed to explore the possibility of incorporating these components in cosmetic products such as sunscreens without causing skin damage.

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Anticancer and antioxidant effects of red cabbage on three cancerous cell lines and comparison with a normal cell line (HFF-3)

Cited by 13 publications

References 13 publications

Development of Novel Markers and Creation of Non-Anthocyanin and Anthocyanin-Rich Broccoli (Brassica oleracea var. italica) Cultivars

Development of Novel Markers and Creation of Non-Anthocyanin and Anthocyanin-Rich Broccoli (Brassica oleracea var. italica) Cultivars

Antioxidant and Antiproliferative Activities of Kale (Brassica oleracea L. Var. acephala DC.) and Wild Cabbage (Brassica incana Ten.) Polyphenolic Extracts

Investigation of Antimicrobial, DNA Protective and Cytotoxic Activity of Red Cabbage (Brassica Oleracea L. Var. Capitata F. Rubra) Plant

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