Anticancer and anti-angiogenesis effect of the leaf extract of <i>Sargassum wightii</i> against osteosarcoma cancer cells

Abstract

&lt;p&gt;This study was aimed to evaluate the chemical composition of ethanolic leaf extract of a marine macro-alga &lt;em&gt;Sargassum wightii&lt;/em&gt; (ELESW) followed by its vascular endothelial growth factor (VEGF) induced anti-angiogenic effect against human umbilical vein endothelial cells (HUVECs). The effect of ELESW on cell viability and its potential against &lt;em&gt;in vivo&lt;/em&gt; angiogenesis was assessed by using the MTT and CAM assay respectively. The phenolic, flavonoid, polysaccharides, and protein content of ELESW were found to be 56.0 ± 4.1 mg GAE/g, 26.3 ± 3.6 mg QE/g, 284.2 ± 6.2 μg/mL, 100.9 ± 8.9 μg/mL, respectively. In angiogenesis, ELESW (100, 500 and 1,000 μg/mL) significantly inhibited VEGF induced angiogenesis as well as VEGF-induced proliferation and tube formation of HUVECs in a dose-dependent manner. Upon stimuli-tion by VEGF, HUVECs rapidly increased reactive oxygen species production, which was significantly blocked by treatment with ELESW. These findings suggesting that &lt;em&gt;S. wightii&lt;/em&gt; could be a valuable candidate of therapeutic efficacy.&lt;/p&gt;

Evaluation of the anti-cancer potential of <i>Mahonia aquifolium</i> extracts via apoptosis and anti-angiogenesis

“…Pleurotus eous polysaccharides suppress angiogenesis in breast cancer cells (Xu et al, 2015). Anti-cancer and anti-angiogenesis effects of the leaf extract of Sargassum wightii against osteosarcoma cancer cells have been reported (Yu et al, 2015).…”

Effect of Pelargonidin isolated from Ficus benghalensis L. on phenotypic changes in zebrafish (Danio rerio) embryos

“…The essential role of angiogenesis in tumor growth was first proposed in 1971 by Judah Folkman. Since the past few decades, research identifying molecular mechanisms that regulate neovascularization has gained an upsurge ( Yu et al, 2015 , Lucioli, 2012 ).…”