Anticancer agents found in environment affect Daphnia at population, individual and molecular levels

Grzesiuk, Małgorzata; Bednarska, Anna; Mielecki, Damian; Garbicz, Damian; Marcinkowski, Michał; Pilžys, Tomaš; Malinowska, Agata; Świderska, Bianka; Grzesiuk, Elżbieta

doi:10.1016/j.aquatox.2019.105288

Cited by 12 publications

(5 citation statements)

References 57 publications

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“…Cisplatin inhibited the growth of bacteria, cyanobacteria, algae, rotifera and aquatic plant with EC 50 varying between 440 µg/L and 1.52 mg/L (Brezovšek et al, 2014;Parrella et al, 2014b;Supalkova et al, 2008;Zounková et al, 2007). It has also affected the reproduction of crustacea by reducing the offspring percentage, the number of eggs and the population growth rate at low concentrations (Grzesiuk et al, 2019;Parrella et al, 2014cParrella et al, , 2014aRusso et al, 2018b). As demonstrated by Parrella et al (2015) study, significant DNA damage was produced at concentrations starting from 30 ng/L (Parrella et al, 2015).…”

Section: Alkylating Agentsmentioning

confidence: 90%

Aquatic ecotoxicology of anticancer drugs: A systematic review

Nassour

Nabhani‐Gebara

Barton

et al. 2021

Science of The Total Environment

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Section: Alkylating Agentsmentioning

confidence: 90%

Aquatic ecotoxicology of anticancer drugs: A systematic review

Nassour

Nabhani‐Gebara

Barton

et al. 2021

Science of The Total Environment

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“…Another study evaluating the exposure of Daphnia pulex and Daphnia pulicaria to cisplatin (also CP) evidenced several effects such as the decrease of eggs number, modified expression of some proteins, and increased level of enzymes participating in DNA repair [115].…”

Section: Ecotoxicological Potencymentioning

confidence: 99%

The Dark Side of Platinum Based Cytostatic Drugs: From Detection to Removal

et al. 2021

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The uncontrolled release of pharmaceutical drugs into the environment raised serious concerns in the last decades as they can potentially exert adverse effects on living organisms even at the low concentrations at which they are typically found. Among them, platinum based cytostatic drugs (Pt CDs) are among the most used drugs in cancer treatments which are administered via intravenous infusion and released partially intact or as transformation products. In this review, the studies on environmental occurrence, transformation, potential ecotoxicity, and possible treatment for the removal of platinum cytostatic compounds are revised. The analysis of the literature highlighted the generally low total platinum concentration values (from a few tens of ng L−1 to a few hundred μg L−1) found in hospital effluents. Additionally, several studies highlighted how hospitals are sources of a minor fraction of the total Pt CDs found in the environment due to the slow excretion rate which is longer than the usual treatment durations. Only some data about the impact of the exposure to low levels of Pt CDs on the health of flora and fauna are present in literature. In some cases, adverse effects have been shown to occur in living organisms, even at low concentrations. Further ecotoxicity data are needed to support or exclude their chronic effects on the ecosystem. Finally, fundamental understanding is required on the platinum drugs removal by MBR, AOPs, technologies, and adsorption.

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“…To better understand the fate and effects of these emerging contaminants in the aquatic environment, several complementary fields of expertise can be used, such as analytical chemistry and ecotoxicology. Long-term ecotoxicity and genotoxicity studies using various species were examined for many cytostatics and various effects were determined with high sensitivity (Białk-Bielińska et al 2017 ; Grzesiuk et al 2019 ; Jureczko and Przystaś. 2019 ; Kovács et al 2015 ; Parrella et al 2015 , 2014; Zounkova et al 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of uptake of the cytostatic methotrexate in Elliptio complanata mussels by LC–MS/MS

Larabie

Jutras

Leclair

et al. 2022

Environ Sci Pollut Res

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Aquatic organisms are continuously exposed to emerging contaminants coming from urban effluents of wastewater treatment plants. The contamination of surface water by those effluents poses a number of environmental risks, and pharmaceuticals are part of this class of effluent contaminants. Various classes of pharmaceuticals are not treated by wastewater treatment plants and anticancer drugs are part of them. The chemotherapy drug methotrexate (MTX) is an emerging contaminant and its growing use with the increase in cancer cases worldwide raises potential risk to aquatic organisms exposed to effluent discharges. However, chemical analyses in exposed freshwater aquatic organisms for ecotoxicological studies are rarely available and no studies have been done yet to accompany ecotoxicological data of exposed filter-feeding organisms. The purpose of this study was to develop a specific and sensitive analytical LC–MS/MS method for the quantification of methotrexate uptake in mussels exposed at different concentrations of the drug. A solid/liquid extraction followed by solid phase extraction (SPE) using an MCX phase purification scheme was optimized. The optimal recovery of 65% and matrix effect of 38% allowed to achieve a limit of quantification of 0.25 ng g−1, with an accuracy of 99–106%, a precision of no more than 3% RSD, and linearity ranging from 0.25 to 25 ng g−1. This methodology was tested with mussels exposed for 96 h at different concentrations (4 to 100 µg L−1) of MTX. The data revealed tissue uptake at concentrations ranging from 0 to 2.53 ng g−1. This suggests that this drug has low uptake potential and this methodology could be used to examine tissue levels of this drug in organisms continuously exposed to urban pollution.

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Anticancer agents found in environment affect Daphnia at population, individual and molecular levels

Cited by 12 publications

References 57 publications

Aquatic ecotoxicology of anticancer drugs: A systematic review

Aquatic ecotoxicology of anticancer drugs: A systematic review

The Dark Side of Platinum Based Cytostatic Drugs: From Detection to Removal

Evaluation of uptake of the cytostatic methotrexate in Elliptio complanata mussels by LC–MS/MS

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