Anticancer Activity of Mannich Bases: A Review of Recent Literature

Roman, Gheorghe

doi:10.1002/cmdc.202200258

Cited by 14 publications

(4 citation statements)

References 176 publications

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“…The structural imidazo (1,2-a) pyridine is present in many physiologically and pharmaceutically active molecules [2]. The other uses for them include anti-cancer [3], antibacterial [4], anti-fungal [5], and antiproliferative [6]. Imidazo [1,2-a] pyrimidines have been also found in a number of investigational drugs, such as zolpidem Hypnotic, Miroprofen (NSAID), DS-I GABAA PAM, Zolimidine Antiulcer, Olprinone cardio stimulant, and Mindronic acid osteoporotic [1].…”

Section: Introductionmentioning

confidence: 99%

“…Studies in the literature showed that Mannich bases are highly reactive and easily transform into other compounds [4], according to the published studies in the literature reduced to produce amino alcohols having physiological action, for instance. It is well-known that Mannich bases have potent effects, such as antiinflammatory, anticancer properties [5], antimicrobial, anti-filarial [6], and anticonvulsant [7].…”

Section: Introductionmentioning

confidence: 99%

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Untitled

2023

J. Med. Chem. Sci.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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“…Additionally, by selecting the appropriate amine reagent, the Mannich reaction can also contribute to enhancing the lipophilic properties of a drug. [48] Extensive literature reports have highlighted the potency of Mannich base-linked 1,2,4-triazole derivatives as antibacterial, [49][50][51] antifungal, [52,53] antitubercular, [54] anti-cancer agents. [55,56] As existing drugs on the market often face challenges such as drug resistance, undesirable toxic side effects, and incompatibility with other drugs, there is an urgent need for the synthesis of novel biologically active compounds.…”

Section: Introductionmentioning

confidence: 99%

A Review of the Synthesis and Biological Activity of Flavonoid Mannich Base Derivatives

Nguyen,

Cong,

Minh An

2023

ChemistrySelect

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Over the past twenty years (1998–2023), extensive research has focused on the synthesis and biological activity of Mannich base derivatives of flavonoids (FMBD), which have demonstrated exceptional properties towards organic and bioorganic molecules. Several research groups have reported the pharmacological potential of these flavonoid derivatives, including antioxidant and antiviral activities, as well as their ability to inhibit AChE and exhibit anticancer properties. Moreover, the unique characteristic of forming stable complexes with biomolecules positions flavonoid derivatives as valuable assets in the realm of biology and drug discovery. In this extensive review, we′ve meticulously analyzed over seventy six distinct research studies on this subject. Our aim is to provide a succinct overview of the wide‐ranging applications of flavonoid derivatives coupled with amines. Furthermore, we explore the promising horizons and potential innovations in this field. It's essential to highlight that these derivatives display no discernible signs of toxicity or eliciting immune responses, making them even more attractive for biopharmaceutical applications. Undoubtedly, the utilization of flavonoid derivatives combined with amines as crucial biopharmaceutical agents is poised for significant expansion in the forthcoming years.

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“…In recent years, the process has received increasing attention due to the variability of the components involved, the use of mild reaction conditions, and the potential biological activity of the end products [ 9 , 10 ]. Among the versatile pharmacological possibility of their application, a prominent field is anticancer therapy; specifically, using them as cytotoxic agents [ 11 , 12 ]. In the modified Mannich reaction ( m Mr), the aminoalkylation of hydroxyquinolines can be achieved [ 13 ], since this moiety can be considered as an N -containing 1-naphthol analogue.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 4-Hydroxyquinolines as Potential Cytotoxic Agents

Csuvik

Szemerédi

Spengler

et al. 2022

IJMS

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The synthesis of alkyl 2-(4-hydroxyquinolin-2-yl) acetates and 1-phenyl-4-(phenylamino)pyridine-2,6(1H,3H)-dione was optimised. Starting from 4-hydroxyquinolines (4HQs), aminomethylation was carried out via the modified Mannich reaction (mMr) applying formaldehyde and piperidine, but a second paraformaldehyde molecule was incorporated into the Mannich product. The reaction also afforded the formation of bisquinoline derivatives. A new 1H-azeto [1,2-a]quinoline derivative was synthesised in two different ways; namely starting from the aminomethylated product or from the ester-hydrolysed 4HQ. When the aldehyde component was replaced with aromatic aldehydes, Knoevenagel condensation took place affording the formation of the corresponding benzylidene derivatives, with the concomitant generation of bisquinolines. The reactivity of salicylaldehyde and hydroxynaphthaldehydes was tested; under these conditions, partially saturated lactones were formed through spontaneous ring closure. The activity of the derivatives was assessed using doxorubicin-sensitive and -resistant colon adenocarcinoma cell lines and normal human fibroblasts. Some derivatives possessed selective toxicity towards resistant cancer cells compared to doxorubicin-sensitive cancer cells and normal fibroblasts. Cytotoxic activity of the benzylidene derivatives and the corresponding Hammett–Brown substituent were correlated.

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Anticancer Activity of Mannich Bases: A Review of Recent Literature

Cited by 14 publications

References 176 publications

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A Review of the Synthesis and Biological Activity of Flavonoid Mannich Base Derivatives

Synthesis of 4-Hydroxyquinolines as Potential Cytotoxic Agents

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