Anticancer activity of four trinuclear cobalt complexes bearing bis(salicylidene)-1,3-propanediamine derivatives

Novel half Salphen cobalt(iii) complexes: synthesis, DNA binding and anticancer studies

“…1c). [12][13][14][15] The latter has garnered considerable interest within the scientific community due to its synthetic accessibility, as well as the electronic and optical tunability, often granting optimal DNA binding properties especially towards non-canonical secondary DNA structures such as G-quadruplexes (G4s). These DNA-motifs, characterized by stacked tetrads of guanines, play crucial roles in cancer development, including telomere integrity maintenance and transcriptional control of oncogenes.…”

Equilibria of complexes in the aqueous cobalt(II)–N-(2-hydroxybenzyl)phenylalanine system and their biological activity compared to analogous Schiff base structures

“…There is a growing need for drugs with high efficacy and low side effects. This demand can be met by coordination chemistry, a very promising field of chemotherapy which can be used to increase the antiproliferative effect of complexes through the careful selection of metals and ligands [8] , [9] .…”

“…It is also found in various cobalt proteins, such as methionine aminopeptidase 2, an enzyme found in humans and other mammals, and nitrile hydratase, an enzyme in bacteria that metabolizes nitriles [10] . It can therefore be assumed that complexes based around cobalt will be safer treatments for cancer or bacterial infections then existing ones [9] . Due to the good therapeutic efficacy of cobalt complexes against liver cancer cells (SK-HEP-1 and HepG2), these compounds can be used in target-based anticancer therapy [11] , [12] .…”