Anticancer Activity of 5-Fluorouracil-Loaded Nanoemulsions Containing Fe3O4/Au Core-Shell Nanoparticles

Shameli, Kamyar; Teow, Sin-Yeang; Yusefi, Mostafa; Kia, Pooneh; Rasouli, Elisa; Tareq, Mohammad Ali

doi:10.1016/j.molstruc.2021.131075

Cited by 19 publications

(13 citation statements)

References 62 publications

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“…However, it was proven that some nanoparticles (NPs) (such as metal NPs) have led to issues for human health because they might cause risks of neurotoxicity and cytotoxicity [2]. Therefore, the use of non-toxic, biodegradable, and biocompatible nanomaterials such as biopolymer can tackle the above problems [2][3][4][5][6][7]. In this manner, chitosan NPs (ChNPs) are extensively popular for many biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Properties of Chitosan Nanoparticles CrossLinked with Tripolyphosphate

Yusefi

Kia

Sukri

et al. 2021

JRNN

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Chitosan nanoparticles (ChNPs) have been extensively examined for various biomedical applications due to their advantages include large surface area, biodegradability, and biocompatibility. The purpose of this research was to synthesize ChNPs using a simple ionic gelation technique by the interaction of low molecular weight chitosan (LMWC) and sodium tripolyphosphate (TPP) as a cross-linking agent. ChNPs, TPP, and LMWC were analysed by X-ray diffraction (XRD) and Fourier transforms infrared (FTIR) spectra that indicated the formation of ChNPs, attributing to the rearrangement of the nanoparticles after adding the TPP cross-linker into the LMWC solution. XRD analysis exhibited that ChNPs were amorphous, due to the effect of TPP cross-linker. Dynamic light scattering showed the nano-dimension of ChNPs with a hydrodynamic size of 68.50 nm. Thus, the obtained results indicated that the properties of chitosan were improved through converting it into nanoparticles using TPP initiated ionic gelation procedure.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Properties of Chitosan Nanoparticles CrossLinked with Tripolyphosphate

Yusefi

Kia

Sukri

et al. 2021

JRNN

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“…The 0.78 μg/mL of synthesized 5-FU-loaded Fe 3 O 4 /Au core–shell NEs showed anticancer activity against colorectal cancer cell lines. A cytotoxic effect was 46% inhibition in HCT116 cell lines, while 15% toward normal cells …”

Section: Application Of Magnetic Nanoparticles For Treating Tumors/ca...mentioning

confidence: 99%

Recent Advances of Magnetic Nanomaterials for Bioimaging, Drug Delivery, and Cell Therapy

Mohsin

Hussain

Mohsin

et al. 2022

ACS Appl. Nano Mater.

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Magnetic nanoparticles (MNPs) are gaining much attention due to their applications in specialized fields, including diagnosis, bioimaging, drug delivery, and cell therapy. In recent years, the field of stem cell and regenerative medicine comprising tissue engineering and drug delivery has been powered by nanoparticles. Particularly, mesenchymal stem cells (MSCs) are characterized with adequate immunomodulatory potential coupled with an excellent regenerative ability that contributes to improved therapy of various diseases. For clinical applications of MSCs, tracking and labeling are crucial to determine cell homing and distribution. Therefore, due to the high potential of MNPs in stem cell therapy, this review comprehensively uncovers the advancements in the respective field. Also, it discusses the usage of surface-functionalized materials in improving the physicochemical properties of MNPs, making them suitable candidates for several biomedical applications. Moreover, we have discussed that these nanoparticles within applied magnetic field and electromagnetic field have been considered multifunctional agents for labeling, stimulating, tracking, and targeting stem cells in vitro and in vivo. Additionally, the discussion comprises the progress and challenges associated with MNPs used as effective therapeutic, delivery, and diagnostic agents to treat cancer, cardiovascular, neurodegenerative, and bone-related disorders. Finally, the review discussed that the magnetic nanoparticles have also been widely used for targeted cancer cell therapy due to mechanical force for killing cancer cells under a magnetic field. It is concluded that the mechanical force produced by MNPs in a low-frequency vibrating magnetic field is the most promising and safe option for the destruction of tumor cells. In short, this review summarized the role of magnetic nanomaterials for effective, safe, and efficient nanomaterial-cell-based therapies.

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“…Therefore, it is essential to develop effective multifunctional 5-FU nanocarriers to improve targeted delivery, resulting in improved anticancer treatments. The following nanocarriers of 5-FU were proposed: polymer-based carriers such as chitosan beads, Eudragit ® , Poly(alkylcyanoacrylates), PLGA, β-cyclodextrin as well as liposomes, nanoemulsions, solid lipid nanoparticles, gold nanoparticles, silica nanocarriers, iron oxides nanoparticles, graphene oxides, and QD [24][25][26][27][28][29][30][31][32][33][34][35] The present contribution aimed to develop a novel method of preparing multifunctional 5-FU nanocarriers and their in vitro characterization. 5-FU polyaminoacid-based core@shell nanocarriers were formed by the encapsulation of drug-loaded nanocores with polyaminoacids multilayer shell via the layer-by-layer method with saturation technique.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polyaminoacid Based Core@shell Nanocarriers of 5-Fluorouracil: Synthesis, Properties and Theranostics Application

Szczęch

Hinz

Łopuszyńska

et al. 2021

IJMS

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Cancer is one of the most important health problems of our population, and one of the common anticancer treatments is chemotherapy. The disadvantages of chemotherapy are related to the drug’s toxic effects, which act on cancer cells and the healthy part of the body. The solution of the problem is drug encapsulation and drug targeting. The present study aimed to develop a novel method of preparing multifunctional 5-Fluorouracil (5-FU) nanocarriers and their in vitro characterization. 5-FU polyaminoacid-based core@shell nanocarriers were formed by encapsulation drug-loaded nanocores with polyaminoacids multilayer shell via layer-by-layer method. The size of prepared nanocarriers ranged between 80–200 nm. Biocompatibility of our nanocarriers as well as activity of the encapsulated drug were confirmed by MTT tests. Moreover, the ability to the real-time observation of developed nanocarriers and drug accumulation inside the target was confirmed by fluorine magnetic resonance imaging (19F-MRI).

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Anticancer Activity of 5-Fluorouracil-Loaded Nanoemulsions Containing Fe3O4/Au Core-Shell Nanoparticles

Cited by 19 publications

References 62 publications

Synthesis and Properties of Chitosan Nanoparticles CrossLinked with Tripolyphosphate

Synthesis and Properties of Chitosan Nanoparticles CrossLinked with Tripolyphosphate

Recent Advances of Magnetic Nanomaterials for Bioimaging, Drug Delivery, and Cell Therapy

Polyaminoacid Based Core@shell Nanocarriers of 5-Fluorouracil: Synthesis, Properties and Theranostics Application

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