Anticancer activity evaluation of the Solanum glycoalkaloid solamargine

Kuo, Kou‐Wha; Hsu, Shu-Hui; Li, Yunping; Lin, Wei-Ling; Liu, Lifeng; Chang, Li-Ching; Lin, Chih-Hao; Lin, Chun‐Nan; Sheu, Hamm Ming

doi:10.1016/s0006-2952(00)00506-2

Cited by 146 publications

(107 citation statements)

References 35 publications

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“…Ex Vivo studies have demonstrated that BEC is effecttive against a wide spectrum of human cancers and that BEC is, in a dose dependent manner, selectively killing cancer cells without harming normal cells [11][12][13][14][15][16]32,34,47,[49][50][51][52]. Figure 4 illustrates the specificity of BEC on cancer cells and lack of effect on normal cells.…”

Section: Kill Cancer Cells Only and Not Normal Cellsmentioning

confidence: 99%

Curaderm<sup>BEC5</sup> for Skin Cancers, Is It? An Overview

Chase¹

2011

JCT

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Section: Kill Cancer Cells Only and Not Normal Cellsmentioning

confidence: 99%

Curaderm<sup>BEC5</sup> for Skin Cancers, Is It? An Overview

Chase¹

2011

JCT

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“…5,8 A variety of agents have been tested with regard to their ability to alter the level of TNFRs, and subsequently alter the effects of TNF. [9][10][11][12] Apoptosis (programmed cell death) plays an important role in the homeostasis and development of all tissues within an organism. Apoptosis can be initiated by a variety of stimuli including growth factor withdrawal, ultraviolet-or g-irradiation and many chemotherapeutic drugs.…”

Section: Introductionmentioning

confidence: 99%

Granulocyte macrophage-colony stimulating factor and interleukin-3 increase expression of type II tumour necrosis factor receptor, increasing susceptibility to tumour necrosis factor-induced apoptosis. Control of leukaemia cell life/death switching

Rae

MacEwan

2004

Cell Death Differ

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Tumour necrosis factor (TNF) induces apoptosis in a range of cell types via its two receptors, TNFR1 and TNFR2. Here, we demonstrate that proliferation and TNFR2 expression was increased in human leukaemic TF-1 cells by granulocyte macrophage-colony stimulating factor (GM-CSF) and interleukin-3 (IL-3), with TNFR1 expression unaffected. Consequently, they switch from a proliferative to a TNF-induced apoptotic phenotype. Raised TNFR2 expression and susceptibility to TNF-induced apoptosis was not a general effect of proliferation as IL-1b and IFN-c both proliferated TF-1 cells with no effect on TNFR expression or apoptosis. Although raised TNFR2 expression correlated with the apoptotic phenotype, stimulation of apoptosis in GM-CSF-pretreated cells was mediated by TNFR1, with stimulation of TNFR2 alone insufficient to initiate cell death. However, TNFR2 did play a role in apoptotic and proliferative responses as they were blocked by the presence of an antagonistic TNFR2 antibody. Additionally, coincubation with cycloheximide blocked the mitotic effects of GM-CSF or IL-3, allowing only the apoptotic responses of TNF to persist. TNF life/death was also observed in K562, but not MOLT-4 and HL-60 human leukaemic cell types. These findings show a cooperative role of TNFR2 in the TNF life/death switching phenomenon.

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“…There have been numerous hypotheses put forth to explain the allocation of secondary metabolites in ripe fleshy fruits (hall et al 2006(hall et al , Li et al 2007, including the retention of high levels of glycoalkaloids in fruits of some Solanum species (Kuo et al 2000, Hall et al 2006.…”

Section: Plant Materials and Extractionmentioning

confidence: 99%

In vitro trypanocidal activity of solamargine and extracts from Solanum palinacanthum and Solanum lycocarpum of brazilian cerrado

Moreira

Martins

Magalhães

et al. 2013

An. Acad. Bras. Ciênc.

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The present investigation was to evaluate the potential trypanocidal activity of crude ethanolic extract of the fruits of Solanum palinacanthum, Solanum lycocarpum and the glycoalcaloid, solamargine. S. palinacanthum and S. lycocarpum fruit powders were submitted to exhaustively extraction with 96% ethanol and solamargine were isolated from the extract of S. palinacanthum. Both extracts and solamargine were analysed for trypanocidal activity by using MTT colorimetric assay. Extracts of S. palinacanthum showed to be more active (IC 50 = 175.9 µg.ml -1 ) than S. lycocarpum (IC 50 = 194.7 µg.ml -1 ). Solamargine presented a strong activity (IC 50 = 15.3 µg.ml -1 ), which can explain the better activity of the both extracts.Benznidazol (IC 50 = 9.0 µg.ml -1 ) is the only drug used to treat Chagas' disease. These findings demonstrate for the first time that ethanol extracts obtained from both fruits of S. palinacanthum and S. lycocarpum and also solamargine have a potential anti-trypanosomal activity.

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Anticancer activity evaluation of the Solanum glycoalkaloid solamargine

Cited by 146 publications

References 35 publications

Curaderm<sup>BEC5</sup> for Skin Cancers, Is It? An Overview

Curaderm<sup>BEC5</sup> for Skin Cancers, Is It? An Overview

Granulocyte macrophage-colony stimulating factor and interleukin-3 increase expression of type II tumour necrosis factor receptor, increasing susceptibility to tumour necrosis factor-induced apoptosis. Control of leukaemia cell life/death switching

In vitro trypanocidal activity of solamargine and extracts from Solanum palinacanthum and Solanum lycocarpum of brazilian cerrado

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Anticancer activity evaluation of the Solanum glycoalkaloid solamargine

Cited by 146 publications

References 35 publications

Curaderm&lt;sup&gt;BEC5&lt;/sup&gt; for Skin Cancers, Is It? An Overview

Curaderm&lt;sup&gt;BEC5&lt;/sup&gt; for Skin Cancers, Is It? An Overview

Granulocyte macrophage-colony stimulating factor and interleukin-3 increase expression of type II tumour necrosis factor receptor, increasing susceptibility to tumour necrosis factor-induced apoptosis. Control of leukaemia cell life/death switching

In vitro trypanocidal activity of solamargine and extracts from Solanum palinacanthum and Solanum lycocarpum of brazilian cerrado

Contact Info

Product

Resources

About

Curaderm<sup>BEC5</sup> for Skin Cancers, Is It? An Overview

Curaderm<sup>BEC5</sup> for Skin Cancers, Is It? An Overview