Anticancer activity and mediation of apoptosis in human HL-60 leukaemia cells by edible sea cucumber (Holothuria edulis) extract

Wijesinghe, W.A.J.P.; Jeon, You Jin; Ramasamy, P.; Wahid, Mohd; Vairappan, Charles Santhanaraju

doi:10.1016/j.foodchem.2013.01.058

Cited by 60 publications

(48 citation statements)

References 21 publications

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“…Second one is the growing interest and mounting discoveries on the medicinal and nutritional properties of the sea cucumbers. Sea cucumbers have been documented to have valuable nutrients such as Vitamin A, Vitamin B1 (thiamine), Vitamin B2 (riboflavin), Vitamin B3 (niacin) and a number of pharmacological activities including anti-angiogenic, anticancer, anticoagulant, anti-hypertension, anti-inflammatory, antimicrobial, antioxidant, antithrombotic, antitumor and wound healing [11,[14][15][16][17][18][19][20][21][22][23][24][25][26][27]. These high-valued constituents and biologically active compounds along with their numerous biological and medicinal properties mostly support towards the effective exploration and potential utilization of sea cucumbers in producing nutraceutical products and functional foods for human health benefits [1,2,11,28].…”

Section: Trends Prospects and Utilizations Of Sea Cucumber Fisheriesmentioning

confidence: 99%

Trends, Prospects and Utilizations of Sea Cucumber Fisheries in Malaysia

2016

IJAAEE

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Abstract-The holothurian or sea cucumber is one of the marine resources, which has been used not only as luxury food for certain countries but also as medicines. Because of its' higher nutraceutical and pharmaceutical values, sea cucumber has become one of the most important products and it has high price in international market and thus provide an important employment and income source to the coastal communities in many Pacific island countries including Malaysia. They have been harvested for hundreds of years for trade with Asia and were probably one of the worthy exports from the Indo-Pacific islands. Unfortunately, the increase in demand and price, combined with the development of cash economies and growing coastal populations in many islands, has led to widespread overfishing of the resource across much of this region. There is a high level of interest in adoption of aquaculture and stock enhancement techniques to restore production phases, but different capacity levels require implementation of different techniques. Some Pacific island countries and territories have completed successful research trials of hatchery, nursery and release techniques, and now have capacity to scale up this activity but such types of research are still in the initial stage in Malaysia. Factors that work in favor of successful aquaculture include pristine marine environments, long familiarity with sea cucumbers as a commodity, and traditional marine tenure systems that in some places can provide a basis for management of released sea cucumbers. Currently, the exploitation of sea cucumber turns out to be excessive and disrupts its sustainability. Aquaculture is the best way to prevent this severe problem. The success of sea cucumber culture is very depending on broodstock management, seed availability and suitable food for larvae as well as juvenile along with appropriate grow-out culture techniques under controlled rearing protocols.

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Section: Trends Prospects and Utilizations Of Sea Cucumber Fisheriesmentioning

confidence: 99%

Trends, Prospects and Utilizations of Sea Cucumber Fisheries in Malaysia

2016

IJAAEE

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“…The presence of triterpenoid glycosides, sulfated polysaccharide, and cerebrosides in sea cucumber body wall confer biological potency to sea cucumbers that is responsible for biomedical applications particularly in oncology [10]. Previous investigations proved anti cancer activity of sea cucumber whole extract and its constituents [11]. Ogushi et al reported the aqueous extract of sea cucumber displayed cytostatic effect on human colon adenocarcinoma Caco-2 cells and revealed anti growth effect as concentration dependent manner [18].…”

Section: Discussionmentioning

confidence: 99%

“…The anti-cancer activities of sea cucumber whole extract already have been studied [11]. It has also eligibility significant cytotoxic effect on human non-small lung carcinoma, leukemia and human colon adenocarcinoma cells.…”

Section: Introductionmentioning

confidence: 99%

Concomitant Use of Sea Cucumber Organic Extract and Radiotherapy on Proliferation and Apoptosis of Cervical (HeLa) Cell Line

Baharara

Amini

Vazifedan

2016

Zahedan J Res Med Sci

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“…Moreover, sea cucumber extracts have potent biological effects and have antiviral, anticancer, antibacterial, antioxidant, and anti-inflammation effects (Esmat et al 2013;Farshadpour et al 2014;Kiani et al 2014;Wijesinghe et al 2013). In China and Malaysia, sea cucumbers have been traditionally used for the remedy of different inflammatory diseases like asthma.…”

Section: Introductionmentioning

confidence: 99%

Effects of different algae in diet on growth and interleukin (IL)-10 production of juvenile sea cucumber Apostichopus japonicus

et al. 2017

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The experiment was conducted to investigate the effects of different algae in diet on growth, survival, and interleukin-10 productions of sea cucumber. At first, a 9-week feeding trail was conducted to evaluate the growth performance and survival of the sea cucumber fed one of the six experimental diets containing ST (Sargassum thunbergii), UL (Ulva lactuca), UP (Undaria pinnatifida), LJ (Laminaria japonica), SS (Schizochytrium sp.), and NO (Nannochloropsis oculata) in a recirculating aquaculture system. The result showed that survival was not significantly different among the dietary treatments, and the specific growth rate (SGR) of sea cucumber fed the UL diet (1.58% d ) was significantly higher than that of sea cucumber fed the other diets (P < 0.05), except for the LJ and NO diets. Secondly, interleukin (IL)-10 gene expression was determined where mice splenocytes were stimulated with 10 μg ml −1 of sea cucumber extracts for 2 h. The result showed that IL-10 gene expression levels were significantly increased in UL, LJ, and NO diets fed sea cucumber extracts compared to other experimental diets. The results suggest that dietary inclusion with Ulva lactuca, Laminaria japonica, and Nannochloropsis oculata algae may improve the growth of juvenile sea cucumber and could upregulate IL-10 gene expression in mice splenocytes. Such detailed information could be helpful in further development of more appropriate diets for sea cucumber culture.

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Anticancer activity and mediation of apoptosis in human HL-60 leukaemia cells by edible sea cucumber (Holothuria edulis) extract

Cited by 60 publications

References 21 publications

Trends, Prospects and Utilizations of Sea Cucumber Fisheries in Malaysia

Trends, Prospects and Utilizations of Sea Cucumber Fisheries in Malaysia

Concomitant Use of Sea Cucumber Organic Extract and Radiotherapy on Proliferation and Apoptosis of Cervical (HeLa) Cell Line

Effects of different algae in diet on growth and interleukin (IL)-10 production of juvenile sea cucumber Apostichopus japonicus

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