Anticancer Activity and Chemical Composition of Leaf Essential Oil from &lt;i&gt;Solidago canadensis L.&lt;/i&gt; in China

Li, De Qiang; Pan, Sheng Hao; Zhu, Xi; Tan, Linhua; Cao, Yuwei

doi:10.4028/www.scientific.net/amr.347-353.1584

Cited by 11 publications

(14 citation statements)

References 27 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The study of Li et al. (2012) [30] has demonstrated a cytotoxicity of the fresh leaves of S. canadensis E.O. on three tumor cell lines (human cervical carcinoma cell lines HeLa, human liver carcinoma cell lines PLC, and human hepatocellular carcinoma cell lines SMMC‐7721) with IC 50 of 156.9, 71.4 and 68.1 μg/ml, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…[29] These results were slightly similar to those we found in our study. The results of Kalemba and Thiem (2004) [27] on the analysis of the E.O from Poland have demonstrated that the major compounds were α-pinene (59.5 %), limonene ( [30] has demonstrated a cytotoxicity of the fresh leaves of S. canadensis E.O. on three tumor cell lines (human cervical carcinoma cell lines HeLa, human liver carcinoma cell lines PLC, and human hepatocellular carcinoma cell lines SMMC-7721) with IC 50 of 156.9, 71.4 and 68.1 μg/ml, respectively.…”

Section: Essential Oil Compositionmentioning

confidence: 99%

See 1 more Smart Citation

Chemical Composition and Antiproliferative Effect of Essential Oils of Four Solidago Species (S. canadensis, S. gigantea, S. virgaurea and S.×niederederi)

Wandjou

Quassinti

Gudžinskas

et al. 2020

Chemistry & Biodiversity

View full text Add to dashboard Cite

There is a growing interest in the research of natural products with potent activity in the prevention and treatment of diseases. Thereby, essential oil phytochemicals have demonstrated broad bioactivities. This study highlights the chemical composition of essential oils obtained from the leaves and inflorescences of diverse species of the genus Solidago (Solidago canadensis, Solidago gigantea, Solidago virgaurea and Solidago × niederederi), also known as Goldenrod, through GC/MS analysis, and their antiproliferative activity on three human tumor cell lines (MDA-MB 231, A375 and HCT116) by the MTT assay. The most represented chemical classes in the essential oils were oxygenated sesquiterpenes, sesquiterpene hydrocarbons, oxygenated monoterpenes and monoterpene hydrocarbons, with a remarkable contribution of compounds such as germacrene D (3.89-19.51 %), α-pinene (3.59-18.82 %), bornyl acetate (3.30-12.73 %) and caryophyllene oxide (3.07-9.18 %). Chemical quali-and quantitative differences were noticed between the leaves and flowers of the same species, as well as between the studied species. The MTT assay showed that the essential oils from the leaves were more active than those from the flower ones. The essential oil having the highest impact on cell viability was that from S.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Essential Oil Compositionmentioning

confidence: 99%

Chemical Composition and Antiproliferative Effect of Essential Oils of Four Solidago Species (S. canadensis, S. gigantea, S. virgaurea and S.×niederederi)

Wandjou

Quassinti

Gudžinskas

et al. 2020

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…D-limonene and carvacrol, of the terpene family, showed to induce apoptosis through the mitochondrial pathway [58,59], similar to the results observed in our study. Another compound, Germacrene D, was found to exhibit a cytotoxic effect on HL-60 cells [60] and human cervical, liver, and hepatocellular carcinoma [61]. Alpha-tocopherol derivatives, another major constituent, has been found to induce cell death and inhibit viability, migration, and invasion of breast cancer cells [62].…”

Section: Discussionmentioning

confidence: 99%

The selective anti-proliferative and pro-apoptotic effect of A. cherimola on MDA-MB-231 breast cancer cell line

Younes

Ammoury

Haykal

et al. 2020

BMC Complement Med Ther

View full text Add to dashboard Cite

Background Herbal medicines have been a major target for numerous studies through the past years as an alternative treatment for cancer, mainly due to their minimal effects on normal healthy cells. Annona cherimola, popularly known as Cherimoya, is an edible natural fruit rich in phytochemical components and known to possess various biological activities. Previous studies have reported the anti-cancerous effect of A. cherimola ethanolic leaf extract (AELE) on leukemia. This study aims at studying the potential anti-cancer activity of this extract in vitro in two different breast cancer cell lines, namely MDA-MB-231 and MCF-7, in addition to investigating its toxicity on normal mesenchymal stem cells. Methods The anti-proliferative effect of AELE was evaluated via cell viability assay. Propidium iodide staining, Cell Death Detection ELISA and flow cytometry analysis of Annexin V binding were used to assess cell cycle progression, DNA fragmentation and apoptosis induction, respectively. Protein expression was determined via Western Blot analysis to decipher the underlying apoptotic molecular mechanism induced upon AELE treatment. Results The anti-proliferative effect of the extract was found to be selective on the triple-negative breast cancer cell line (MDA-MB-231) in a time- and dose-dependent manner with an IC50 of 390.2 μg/mL at 48 h, with no cytotoxic effects on normal murine mesenchymal stem cells. The pro-apoptotic effect was confirmed by the increase in cellular and DNA fragmentation, flipping of the phosphatidylserine moiety to the outer leaflet, and the increase in Annexin V binding. The underlying molecular mechanism revealed the involvement of the mitochondrial pathway, as shown by alterations in mitochondrial permeability and the upregulation of cytochrome c expression. Conclusion All the data presented in our study suggest that AELE exhibits a selective anti-proliferative and pro-apoptotic effect on the chemo-resistant MDA-MB-231 breast cancer cells, providing evidence for the anti-tumor effects of A. cherimola.

show abstract

“…The essential oil of the Solidago genus have been chemically and biologically previously reported to many species as S. altissima, S. gigantea (Fujita et al 1979), S. virgaurea (Fujita 1991), S. canadensis (Weyerstahl et al 1993;Kasali et al 2002), S. graminifolia (Kalemba 1992), S. virgaurea (Kalemba 1998), S. chilensis (Gressler et al 2003;Duarte et al 2005) and these biological activities described were antifungal and (Gressler et al 2003;Li et al 2011), antimicrobial (Duarte et al 2005). The essential oil from Solidago canadensis leaf was tested for cytotoxic activities against three tumor cell lines (Yoshihara et al 1969;Steliopoulos et al 2002).…”

Section: Introductionmentioning

confidence: 97%

Chemical composition and antinociceptive activity of volatile fractions of the aerial parts of Solidago chilensis (Compositae)

et al. 2020

View full text Add to dashboard Cite

Thirty-six compounds were identified from aerial parts of Solidago chilensis cultivated at PAF/FIOCRUZ campus in Rio de Janeiro city (RJ) using solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS) analysis. These compounds are mainly non-oxygenated mono and sesquiterpenes. Germacrene D is the major compound of two the essential oil analyzed samples (12 to 23%) and of two of the volatiles samples analyzed by SPME (central stems and dry inflorescences samples). Limonene is the major compound in the fresh inflorescences sample (about 21%). The bornil acetate is present in both volatile fractions (16%) and essential oils (7-8%). All the essential oils samples evaluated shown a great antinociceptive activity, considering the used dose of the samples (1 mg/kg) and the standard substance (50 mg/kg). Solidago chilensis is one of Brazil arnicas and it is a medicinal plant widely used by the brazilian population. Other plants of the genus Solidago are also used in traditional medicine in North America and Europe. This is the first report of SPME analysis from Solidago genus and of the antinociceptive effect from Solidago chilensis essential oil.

show abstract

Anticancer Activity and Chemical Composition of Leaf Essential Oil from <i>Solidago canadensis L.</i> in China

Cited by 11 publications

References 27 publications

Chemical Composition and Antiproliferative Effect of Essential Oils of Four Solidago Species (S. canadensis, S. gigantea, S. virgaurea and S.×niederederi)

Chemical Composition and Antiproliferative Effect of Essential Oils of Four Solidago Species (S. canadensis, S. gigantea, S. virgaurea and S.×niederederi)

The selective anti-proliferative and pro-apoptotic effect of A. cherimola on MDA-MB-231 breast cancer cell line

Chemical composition and antinociceptive activity of volatile fractions of the aerial parts of Solidago chilensis (Compositae)

Contact Info

Product

Resources

About