Chemical composition and antinociceptive activity of volatile fractions of the aerial parts of Solidago chilensis (Compositae)

Abstract

Thirty-six compounds were identified from aerial parts of Solidago chilensis cultivated at PAF/FIOCRUZ campus in Rio de Janeiro city (RJ) using solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS) analysis. These compounds are mainly non-oxygenated mono and sesquiterpenes. Germacrene D is the major compound of two the essential oil analyzed samples (12 to 23%) and of two of the volatiles samples analyzed by SPME (central stems and dry inflorescences samples). Limonene is the major compound in the fresh inflorescences sample (about 21%). The bornil acetate is present in both volatile fractions (16%) and essential oils (7-8%). All the essential oils samples evaluated shown a great antinociceptive activity, considering the used dose of the samples (1 mg/kg) and the standard substance (50 mg/kg). Solidago chilensis is one of Brazil arnicas and it is a medicinal plant widely used by the brazilian population. Other plants of the genus Solidago are also used in traditional medicine in North America and Europe. This is the first report of SPME analysis from Solidago genus and of the antinociceptive effect from Solidago chilensis essential oil.

Avaliação química e microbiológica do óleo essencial de Cymbopogon densiflorus (Poaceae)

“…Os compostos obtidos como limoneno (13,07%), trans-p-menta-2,8-dienol (12,17%) possuem maior concentração de ativo devido sua sintetização ocorrer predominantemente nas inflorescências e ser precursor da síntese de outros terpenos (TABELA 1) e sugerem maior atividade antimicrobiana [30] .…”

Anti‐Inflammatory Activity and Chemical Analysis of Different Fractions from Solidago chilensis Inflorescence

“…chilensis is part of the Brazilian National List of Medicinal Plants of Interest to Unified National Health System, and extracts obtained from rhizomes and inflorescences have been produced for anti-inflammatory use [13]. Although the activity of S. chilensis is evidenced in the literature, there are few studies with enriched/characterized fractions or isolated compounds, especially concerning extracts obtained from the inflorescences, relating them to the anti-inflammatory and antinociceptive activities already well described in this plant species [9,14]. The generation of this knowledge can help in the identification of phytochemical markers that can be used in the future in the quality control of S. chilensis-based products.…”

A administração sistêmica de extratos de arnica é segura? Uma revisão sistemática de ensaios pré-clínicos

“…Moreover, the therapeutic effects of these species have been demonstrated through pre-clinical studies (Bernardes et al, 2021;Caldeira et al, 2019;da Silva Prade et al, 2020;de Barros et al, 2016;de Sá Müller et al, 2019;Valverde et al, 2020;Vogas et al, 2020) and clinical trials (Iannitti et al, 2016;Mawardi et al, 2020;Raghibi et al, 2018;Silva et al, 2015;Sorrentino et al, 2017), and was attributed to appreciable amounts of several phytochemical markers in the phytocomplex, such as: sesquiterpene lactones; flavonoid glycosides; chlorogenic acid derivatives; tannins; resins; coumarins; carotenoids; inulin; arnicacin; phytosterine; and triterpenes (arnidiol, pradiol and amisterine) (Athayde et al, 2019;Caldeira et al, 2019;de Barros et al, 2016;Meinhart et al, 2017).…”