Anticancer activities of various new metal complexes prepared from a Schiff base on A549 cell line

Aslan, Halime Güzin; Akkoç, Senem; Kökbudak, Zülbiye

doi:10.1016/j.inoche.2019.107645

Cited by 39 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the lowest IC 50 values (half maximal inhibitory concentration) for both assays were observed for the dinuclear Pt-agent—an IC 50 of 1.6 µM at 72 h in the MTT assay, and of 0.4 µM at 48 h in the SRB test ( Table 1 ). This complex displayed a higher cytotoxic activity against this cell line than those reported for other inorganic metal complexes with Schiff base ligands—having Ni(II), Cu(II), Co(II), Ag(I), Pd(II), Pt(II), Cr(III) or Mn(II) as metal centers—which presented IC 50 values ranging from 9.40 to 25.58 µM (IC 50 = 18.88 µM for the Pt(II) complex) after 72 h of incubation time [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line

et al. 2023

View full text Add to dashboard Cite

A dinuclear Pt(II) complex with putrescine as bridging polyamine ligand ([Pt2Put2(NH3)4]Cl4) was synthesized and assessed as to its potential anticancer activity against a human non-small cell lung cancer line (A549), as well as towards non-cancer cells (BEAS-2B). This effect was evaluated through in vitro cytotoxicity assays (MTT and SRB) coupled to microFTIR and microRaman spectroscopies, the former delivering information on growth-inhibiting and cytotoxic abilities while the latter provided very specific information on the metabolic impact of the metal agent (at the sub-cellular level). Regarding cancer cells, a major impact of [Pt2Put2(NH3)4]Cl4 was evidenced on cellular proteins and lipids, as compared to DNA, particularly via the Amide I and Amide II signals. The effect of the chelate on non-malignant cells was lower than on malignant ones, evidencing a promising low toxicity towards healthy cells.

show abstract

Section: Resultsmentioning

confidence: 99%

A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Each sample was dissolved in DMSO, which has low or insignificant cytotoxic effect on both tumor and normal cells (inhibition rate percent IR percent) before and after loading with AuNPs or NiNPs -fullerene nanocarriers. 58 At different exposure times (24, 48, and 72 hours), pemetrexed loaded with gold nanoparticles (AuNPs)-fullerene nanocarrier (SG10) had a lower IC50 (1.55 µM) and a higher cytotoxic effect on A549 cancer cells (Figure 7). So drug loaded on Au-fullerene had significantly lower IC50 than the pure drug, which revealed the significant contribution of AuNPs available in reducing IC50 of pemetrexed.…”

Section: Cytotoxic Activity Of Pemetrexed Loaded Nanocarriermentioning

confidence: 99%

Efficacy of Gold and Nickel on the Anticancer Activity and Physical Properties of Pemetrexed Loaded on Fullerene C60 Buckysomes

Mahdi¹,

Maraie²,

Dawood³

2022

IJDDT

View full text Add to dashboard Cite

Objective: This study aims to create a new delivery system for pemetrexed, employing a metal-C60 fullerene combination for the first time. Additionally, a lung cancer cell line study will be used to examine the impact of this combination on the release, behavior, and drug’s cytotoxicity. Methods: To utilize a laser to irradiate hydrocarbons, fullerene C60 (Buckysomes) was produced and then nanosized by adding different volumes of isopropyl alcohol and ultrasonication. Gold Nanoparticles (AuNPs) and nickel nanoparticles (NiNPs) were also prepared each one separately and added to the previous mixture together with Pemetrexed (PMX) with further ultrasonication for 20 minutes. The mixture is kept in the refrigerator for 20 hours and then filtered. The precipitate was dried and characterized for particle size, invitro release, and anticancer activity in comparison to pemetrexed loaded on C60 fullerene previously prepared in our laboratory. Results: The evaluation techniques revealed the successful loading of pemetrexed on metals- fullerene C60 nanocarrier, SG10 was the optimum sample with % of yield reach to 95.36. The release profile shows that the percentage release of pemetrexed after 240 minutes is equal to 40% from pure PMX, while the release after 240 minute was found to be 87.8 % from pemetrexed loaded gold nanoparticles (AuNPs) fullerene C60 nanocarrier (SG10), while NiNPs not significantly improved the release profile of Pemetrexed from Pemetrexed loaded NiNPs – fullerene (SN7). Pemetrexed loaded on gold nanoparticles (AuNPs), when compared to pure PMX (3.1 M) and SN7 (11.5 M), fullerene nanocarrier (SG10) exhibits a lower IC50 (1.55 M) and a greater cytotoxic effect (high IR percent) on A549 cancer cells. Pemetrexed’s cytotoxicity in A549 was enhanced after being loaded onto gold nanoparticles (AuNPs)-fullerene nanocarriers (90.4% cell death for SG10) as opposed to pure drug (60% cell death). This finding suggests that the loading process enhanced the drug’s cytotoxic activity for the tumor cells, which may have sped up the onset of action (30% cell death after 24 hours). Conclusion: This study successfully prepared Metals- fullerene C60 Buckysomes loaded with pemetrexed utilizing gold and nickel, which may serve (especially Au- fullerene) as a suitable nanocarrier for pemetrexed, resulting in an improvement to solubility, the release pattern, and cytotoxicity.

show abstract

“…Pyrimidine derivatives are an interesting class of heterocycles with remarkable biological and pharmacological activities [1] . Compounds containing a pyrimidine core have a range of diverse biological activities such as antibacterial [2] , antifungal [3] , anti-inflammatory [4] , antihypertensive [5] , antiviral [6] , anti-HIV [7] , antidiabetic [8] , anti-allergic [9] , herbicidal [10] and anticancer [11] , [12] , [13] . Most of the sugar, vitamins, and alkaloids are nitrogenous bases, which are found in many antibiotics like penicillin [14] .…”

Section: Introductionmentioning

confidence: 99%

DFT investigations and molecular docking as potent inhibitors of SARS-CoV-2 main protease of 4-phenylpyrimidine

Celik

2023

Journal of Molecular Structure

View full text Add to dashboard Cite

Anticancer activities of various new metal complexes prepared from a Schiff base on A549 cell line

Cited by 39 publications

References 21 publications

A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line

A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line

Efficacy of Gold and Nickel on the Anticancer Activity and Physical Properties of Pemetrexed Loaded on Fullerene C60 Buckysomes

DFT investigations and molecular docking as potent inhibitors of SARS-CoV-2 main protease of 4-phenylpyrimidine

Contact Info

Product

Resources

About