Anticancer activities of parthenolide in primary effusion lymphoma preclinical models

Karam, Louna; Staiteieh, Soumaiah Abou; Chaaban, Rady; Hayar, Berthe; Ismail, Bassel; Neipel, Frank; Darwiche, Nadine; Merhi, Raghida Abou

doi:10.1002/mc.23324

Cited by 19 publications

(13 citation statements)

References 59 publications

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“…PTL can induce apoptosis by the initiation of DNA hypomethylation, histone acetylation, enhancement of oxidative stress via endoplasmic reticulum or thiol depletion, and activation of p53. In addition, PTL has shown its ability to significantly inhibit cell growth and induce G0/G1 cell cycle arrest [ 310 ] via several mechanisms such as transcriptional regulation, signal transduction modulation, and induction of oxidative stress [ 78 ]. In prostate cancer cells, PTL induces cell cycle arrest via the inhibition of miR-375 [ 311 ].…”

Section: Plant-derived Natural Products With Potential Anticancer Eff...mentioning

confidence: 99%

Plants as a Source of Anticancer Agents: From Bench to Bedside

et al. 2022

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Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack of selectivity and serious side effects. Cancer hallmarks are biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple cancer hallmarks is a promising strategy to treat cancer. The diversity in chemical structure and the relatively low toxicity make plant-derived natural products a promising source for the development of new and more effective anticancer therapies that have the capacity to target multiple hallmarks in cancer. In this review, we discussed the anticancer activities of ten natural products extracted from plants. The majority of these products inhibit cancer by targeting multiple cancer hallmarks, and many of these chemicals have reached clinical applications. Studies discussed in this review provide a solid ground for researchers and physicians to design more effective combination anticancer therapies using plant-derived natural products.

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Section: Plant-derived Natural Products With Potential Anticancer Eff...mentioning

confidence: 99%

Plants as a Source of Anticancer Agents: From Bench to Bedside

et al. 2022

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“…Massive apoptosis was recently found following PN treatment in different both in vitro and in vivo tumor models [ 113 ].…”

Section: Parthenolide and Cell Deathmentioning

confidence: 99%

Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties

et al. 2022

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Due to its chemical properties and multiple molecular effects on different tumor cell types, the sesquiterpene lactone parthenolide (PN) can be considered an effective drug with significant potential in cancer therapy. PN has been shown to induce either classic apoptosis or alternative caspase-independent forms of cell death in many tumor models. The therapeutical potential of PN has been increased by chemical design and synthesis of more soluble analogues including dimethylaminoparthenolide (DMAPT). This review focuses on the molecular mechanisms of both PN and analogues action in tumor models, highlighting their effects on gene expression, signal transduction and execution of different types of cell death. Recent findings indicate that these compounds not only inhibit prosurvival transcriptional factors such as NF-kB and STATs but can also determine the activation of specific death pathways, increasing intracellular reactive oxygen species (ROS) production and modifications of Bcl-2 family members. An intriguing property of these compounds is its specific targeting of cancer stem cells. The unusual actions of PN and its analogues make these agents good candidates for molecular targeted cancer therapy.

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“…Chemically, it consists of an α-methylene-γ-lactone ring and epoxide group, which are responsible for interacting with nucleophilic sites of biological molecules [ 221 ] ( Figure 9 ). PTL is extracted from different plants of the Asteraceae family [ 222 ] and is the main constituent of the feverfew medicinal plant, Tanacetum parthenium [ 223 ]. Generally, it possesses diverse biological activity extending from antibacterial, anti-inflammatory, and phytotoxic to antitumor activity [ 224 ].…”

Section: Combination Therapies Based On Selected Natural Productsmentioning

confidence: 99%

“…Mostly, by inhibiting the nuclear transcription factor-kappa (NF-κB) signaling pathway and cell growth [ 221 ]. Add to that its ability to induce apoptosis and G0/G1 cell cycle arrest [ 223 ]. PTL stimulated apoptosis in 50–200 µmol/L concentration in human uveal melanoma cells [ 228 ].…”

Section: Combination Therapies Based On Selected Natural Productsmentioning

confidence: 99%

“…In addition, PTL sensitized colorectal cancer cells resistant to tumor necrosis factor-related apoptosis-inducing ligand. That was achieved by increasing the surface expression of death receptor 5 proteins, upregulating the expression of proteins elaborate in the mitochondrial apoptotic pathway, and lastly increasing caspase activation [ 223 ]. Se-lim Kim et al demonstrated that using (5 or 10 μmol/L) PTL combination with 20 mmol/L balsalazide in vitro and in vivo improved the anticancer activity via blocking NF-κB activation.…”

Section: Combination Therapies Based On Selected Natural Productsmentioning

confidence: 99%

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Combination Anticancer Therapies Using Selected Phytochemicals

et al. 2022

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Cancer is still one of the most widespread diseases globally, it is considered a vital health challenge worldwide and one of the main barriers to long life expectancy. Due to the potential toxicity and lack of selectivity of conventional chemotherapeutic agents, discovering alternative treatments is a top priority. Plant-derived natural products have high potential in cancer treatment due to their multiple mechanisms of action, diversity in structure, availability in nature, and relatively low toxicity. In this review, the anticancer mechanisms of the most common phytochemicals were analyzed. Furthermore, a detailed discussion of the anticancer effect of combinations consisting of natural product or natural products with chemotherapeutic drugs was provided. This review should provide a strong platform for researchers and clinicians to improve basic and clinical research in the development of alternative anticancer medicines.

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Anticancer activities of parthenolide in primary effusion lymphoma preclinical models

Cited by 19 publications

References 59 publications

Plants as a Source of Anticancer Agents: From Bench to Bedside

Plants as a Source of Anticancer Agents: From Bench to Bedside

Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties

Combination Anticancer Therapies Using Selected Phytochemicals

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