Antibody to Hepatitis B Virus Induced by Injecting Antibodies to the Idiotype

Kennedy, R C; Melnick, J L; Gr, Dreesman

doi:10.1126/science.6198721

Cited by 62 publications

(10 citation statements)

References 28 publications

(21 reference statements)

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“…(11) found a monoclonal antibody specific for A48 Id borne by ABAC48 or [32-6 fructosan binding protein able to elicit an anti-[32-6 fructosan response in BALB/c mice. Strong antiviral antibody responses were also obtained in mice by injection of rabbit anti-Id antibodies against monoclonal antibodies specific for HBV (12) or rabies (13).…”

mentioning

confidence: 98%

Internal Antigen and Immune Network

Köhler¹,

Müller²,

Bona³

1985

Experimental Biology and Medicine

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mentioning

confidence: 98%

Internal Antigen and Immune Network

Köhler¹,

Müller²,

Bona³

1985

Experimental Biology and Medicine

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“…Jerne et al (20) classified anti-Id Abs in two categories: Ab^a, or conventional anti-Id Abs and Abpß, anti-Id Abs carrying the internal image or the antigens. There are numerous 132 studies indicating that anti-Id Abs enhance the immune responses against bacterial (8), viral (22)(23)(24)(25)(26) and parasitic antigens (27). However, there are no clear cut immunochemical or structural criteria to distinguish Abpoc from Ab2ß (24).…”

Section: Discussionmentioning

confidence: 99%

Effect of Syngeneic Anti-Idiotypic Antibody on Influenza Virus Neuraminidase Antibody Response

Mayer¹,

Ioannides²,

Moran³

et al. 1987

Viral Immunology

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Influenza viruses possess two major surface glycoproteins - hemagglutinin (HA) and neuraminidase (NA). Py203, a monoclonal antibody (Ab) specific for the neuraminidase of the PR8 (H1N1) influenza virus, was used to prepare syngeneic monoclonal anti-idiotypic (anti-Id) Abs. From a BALB/c mouse immunized with Py203 (anti-N1), we obtained RM1, a monoclonal anti-Id Ab. The Py203-Id was detected in a significant fraction of immunoglobulins (Igs) in the primary and secondary responses elicited by PR8 (H1N1) and X31 (H3N2) viruses. In animals injected with minute amounts of RM1 and subsequently boosted with an identical dose of RM1, no detectable anti-NA activity was noted, but a significant increase in Py203-Id-bearing Igs was observed. In the sera of animals injected with minute amounts of RM1 and subsequently boosted with PR8 (H1N1) or X31 (H3N2) viruses, an increase in anti-NA activity and in the level of Py203-Id was noted. Animals injected with large amounts of RM1 and boosted with PR8 and X31 showed a marked suppression of the Py203-Id but no alteration in the anti-NA response. The anti-Id recognizes an idiotope (the Py203 idiotope) shared by antibodies specific for the N1 and N2 neuraminidase variants.

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“…Anti-idiotypic antibodies have been advocated as alternatives to traditional vaccines (Fields & Greene, 1982;Reagan et al, 1983;Ertl & Finberg, 1984;Hay et at., 1984;Kennedy et aL, 1984b;GelI & Moss, 1985 ;Utydehaag & Osterhaus, 1985) but in viral systems have been so far without notable success. In our own investigations with anti-idiotypic reagents against monoclonal antibodies to HSV-I glycoproteins, we have observed only weak cellular responses and no measurable antibody following administration to mice in vivo (Lathey et al, 1986(Lathey et al, , 1987.…”

Section: Split Tolerance In Anti-id C and Hsv-1 Dth-suppressed Micementioning

confidence: 99%

Suppression of Delayed Type Hypersensitivity to Herpes Simplex Virus Type 1 Following Immunization with Anti-idiotypic Antibody: an Example of Split Tolerance

Lathey¹,

Martin²,

Rouse

1987

Journal of General Virology

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SUMMARYIntraperitoneal (i.p.) immunization with herpes simplex virus type 1 (HSV-1) or an anti-idiotypic antibody (anti-id C) prepared against a monoclonal antibody specific for glycoprotein C of HSV-1, tolerizes mice for an HSV-I delayed type hypersensitivity (DTH) response. This tolerization could be adoptively transferred to naive Xirradiated mice by splenic T cells, and was specific for HSV-1 DTH. Thus, DTHtolerized mice responded to vaccinia virus or HSV-2 challenge, while remaining tolerized for HSV-1 DTH. In addition, these animals demonstrated a form of split tolerance such that HSV antibody, cytotoxic T cell and lymphoproliferative responses were detected in vitro. Thus, anti-id C induced a T cell population capable of specifically suppressing the HSV-1 DTH response, mimicking the effect of i.p. and intravenous immunization with HSV-1 found previously.

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Antibody to Hepatitis B Virus Induced by Injecting Antibodies to the Idiotype

Cited by 62 publications

References 28 publications

Internal Antigen and Immune Network

Internal Antigen and Immune Network

Effect of Syngeneic Anti-Idiotypic Antibody on Influenza Virus Neuraminidase Antibody Response

Suppression of Delayed Type Hypersensitivity to Herpes Simplex Virus Type 1 Following Immunization with Anti-idiotypic Antibody: an Example of Split Tolerance

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