Antibody titres against canine papillomavirus 1 peak around clinical regression in naturally occurring oral papillomatosis

Sancak, Aziz Arda; Favrot, Claude; Geisseler, Marco; Müller, Martin; Lange, Christian E.

doi:10.1111/vde.12189

Cited by 26 publications

(26 citation statements)

References 9 publications

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“…The most common clinical manifestations may include canine oral papillomatosis, cutaneous exophytic and endophytic papillomas, and pigmented viral plaques . In dogs, spontaneous remission is reported to occur anywhere from one to 12 months . The purpose of this case report is to describe multimodal treatment of dog with rapidly progressing, disseminated lesions.…”

Section: Case Reportmentioning

confidence: 99%

“…2 In dogs, spontaneous remission is reported to occur anywhere from one to 12 months. [2][3][4] The purpose of this case report is to describe multimodal treatment of dog with rapidly progressing, disseminated lesions.…”

Section: Case Reportmentioning

confidence: 99%

“…Viral papillomatosis is typically a self-limiting disease of young or immunocompromised animals, as most lesions will spontaneously resolve without therapeutic intervention. 2,3 Rarely, atypical manifestations are reported that either do not regress spontaneously, 5 or result in such severe disease burden that therapeutic intervention is requested by the owners. This case report outlines a multimodal treatment protocol in a dog with disseminated cutaneous papillomatosis (CPV2) where administration of azithromycin led to no apparent improvement.…”

Section: Case Reportmentioning

confidence: 99%

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Multimodal treatment of a dog with disseminated cutaneous viral papillomatosis

Levy

Sample

Yuan

2017

Veterinary Dermatology

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Background Canine papillomaviruses (CPVs) are associated with varied cutaneous manifestations. Spontaneous resolution typically occurs within one to 12 months. This case report describes multimodal treatment of a dog with severe disseminated papillomatosis. Clinical summary An eight‐month‐old, female spayed, mixed breed dog was presented with a two month history of rapidly progressing papillomatosis and lack of response to oral azithromycin therapy. The dog was severely pruritic and malodorous; the weight and growth of lesions had progressed to affect the dog's gait and vision, and led to decreased quality of life. The dog was treated with substantial surgical debulking of lesions, followed by daily topical 5% imiquimod cream applied to nonexcisable lesions, and received five doses of an experimental recombinant CPV2 L1 vaccine every 14 days for 10 weeks. At the end of the 10 weeks, two lesions remained and were excised. No additional treatment was needed and 10 months post‐treatment the dog was lesion free. Conclusion New therapies need to be developed and assessed, in controlled treatment trials, to determine the efficacy of single modality therapeutic interventions for severe, persistent canine cutaneous papillomatosis.

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Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

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Multimodal treatment of a dog with disseminated cutaneous viral papillomatosis

Levy

Sample

Yuan

2017

Veterinary Dermatology

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“…Seventeen CPV types have been proposed and grouped into genera Lambdapapillomavirus (CPV1 and 6), Taupapillomavirus (CPV2, 7, 13 and 17) and Chipapillomavirus (CPV3, 4, 5, 8, 9, 10, 11, 12, 14, 15 and 16) (Table ). CPV1, long known as the canine oral papillomavirus (CoPV), is associated with oral papillomatosis (Porcellato et al., ; Sancak et al., ), together with CPV13 (Lange et al., ), and possibly, a subset of conjunctival lesions (Brandes et al., ). However, most oral papillomas do not progress to invasive cancers and papillomaviral DNA is rarely detected in canine oral squamous cell carcinomas (SCC) (Porcellato et al., ; Munday et al., ).…”

Section: Papillomavirus In Companion Animals: Which Viruses Cause Whimentioning

confidence: 99%

An Update on Canine, Feline and Bovine Papillomaviruses

Costa

Peleteiro

Pires

et al. 2016

Transbound Emerg Dis

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Over recent years, a growing number of papillomaviruses have been identified, which cause a wide range of lesions in domestic and wild animals. Papillomavirus-induced lesions may have a great impact on animal health, and some diseases observed in farm animals are associated with significant economic losses. This concise review brings together recent advancements on animal papillomavirus research, providing the scientific community and veterinary practitioners with an update on this rapidly evolving field. Among others, bovine, canine and feline papillomaviruses (BPV, CPV and FcaPV) are most extensively discussed, in view of the recent discovery of new viral types and their worldwide importance for animal health. Feline papillomaviruses 2 is an emerging, highly prevalent pathogen in domestic cats, associated with a subset of malignant skin lesions. Aspects related to cross-species infection by BPV and its environmental co-factors are also addressed. Animal papillomaviruses are also fascinating models for studying molecular and cell biology and have recently inspired some major breakthroughs. Overall, it is clear that additional, international and systematic efforts are needed to clarify which lesions are caused by which viral types and to develop experimental models for studying animal papillomavirus.

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“…Thus far, only CPV type 1 (CPV1) and CPV13 have been isolated from canine oral papillomas (4). The circular double-stranded DNA (dsDNA) virus belongs to the genus Lambda from the Papillomaviridae family (1).…”

Section: Genome Announcementmentioning

confidence: 99%