Antibody responses to P. falciparum Apical Membrane Antigen 1(AMA-1) in relation to haemoglobin S (HbS), HbC, G6PD and ABO blood groups among Fulani and Masaleit living in Western Sudan

Saleh, Ayman; Eltoum, Muna; Abushouk, Amir; Hamza, Anhar; Aljada, Ahmad; El-toum, Mohamed E.; Abu-Zeid, Yousif A.; Allam, Gamal; ElGhazali, Gehad

doi:10.1016/j.actatropica.2018.02.030

Cited by 6 publications

(3 citation statements)

References 74 publications

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“…Individuals with blood group O may be selectively advantaged from the co-existence of anti-A and anti-B antibodies shared by microorganisms [ 31 ]. Diversity of surface glycan molecules in red blood cells and ligands such as merozoite surface protein 1, apical membrane antigen 1 and erythrocyte-binding antigen in Plasmodium may also lead to different host susceptibility [ 11 , 32 , 33 ]. Reduced resetting is potentially another mechanism involved in it [ 11 , 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

ABO blood group and risk of malaria during pregnancy: a systematic review and meta-analysis

Wang

et al. 2022

Epidemiol. Infect.

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The association between ABO blood group and risk of malaria during pregnancy has not been clearly established. The present study summarized relevant knowledge and reassessed the association through meta-analysis. Articles in MEDICINE and PubMed published before November 30, 2021 were searched. Five studies satisfied the inclusion criteria and were enrolled in the meta-analysis. It was shown that primiparae with different ABO blood group, multiparae with blood group A and non-A, AB and non-AB had comparable risk of malaria. However, multiparae with blood group B had significantly higher risk than non-B group (odds ratio (OR) = 1.23, 95% confidence interval (CI) was 1.01 to 1.50, P = 0.04), while multiparae with blood group O had significantly lower risk than non-O group (OR = 0.78, 95% CI was 0.63 to 0.97, P = 0.03). Therefore, ABO blood group may not result in different risk of malaria in primiparae. Blood group B is potentially a risk factor while blood group O is a protective factor for multiparae.

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Section: Discussionmentioning

confidence: 99%

ABO blood group and risk of malaria during pregnancy: a systematic review and meta-analysis

Wang

et al. 2022

Epidemiol. Infect.

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“…IgG subclass antibodies were measured against the recombinant AMA-1 anti-malarial antigen. The total levels of IgG and its subclasses were measured using enzyme-linked immunosorbent assays (ELISA) as previously described in detail [ 11 , 21 ], and as recently reported [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children

Aljada

Hamid

Elsheikh

et al. 2021

Malar J

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Background The FcγRs genotypes have been reported to play a key role in the defence against malaria parasites through both cellular and humoral immunity. This study aimed to investigate the possible correlation between FcγR (IIa, IIIa, and IIIb) genes polymorphism and the clinical outcome for anti‐malarial antibody response of Plasmodium falciparum infection among Saudi children. Methods A total of 600 volunteers were enrolled in this study, including 200 malaria-free control (MFC) subjects, 218 patients with uncomplicated malaria (UM) and 182 patients with severe malaria (SM). The FcγR genotypes were analysed using PCR amplification methods, and measurements of immunoglobulin were determined using enzyme-linked immunosorbent assay (ELISA) technique. Results The data revealed that the FcγRIIa-R/R131 showed a statistically significant association with SM patients when compared to UM patients. Furthermore, higher levels of IgG1, IgG2, and IgG4 were associated with the FcγRIIa-H/H131 genotype among UM patients. Although the FcγRIIa-F/V176 genotype was not associated with UM, it showed a significant association with severe malaria. Interestingly, the FcγRIIIa-V/V176 genotype offered protection against SM. Moreover, SM patients carrying the FcγRIIIa-F/F genotype showed higher levels of AMA-1-specific IgG2 and IgG4 antibodies. The FcγRIIIb-NA1/NA1 and FcγRIIIb-NA2/NA2 genotypes did not show significant differences between the UM and the MFC groups. However, the genotype FcγRIIIb-NA2/NA2 was statistically significantly associated with SM patients. Conclusions The data presented in this study suggest that the influence of the FcγRIIa-R/R131, FcγRIIIa-F/F176 and FcγRIIIb-NA2/NA2 genotypes are statistically significantly associated with SM patients. However, the FcγRIIa-H/H13 and FcγRIIIa-V/V176 genotypes have demonstrated a protective effect against SM when compared to UM patients. The impact of the FcyR (IIa, IIIa and IIIb) gene variants and anti-malaria IgG subclasses play an important role in susceptibility to malaria infection and disease outcome in Saudi children.

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“…Enzyme-linked immunosorbent assays (ELISA) IgG subclasses antibodies were measured against the recombinant AMA-1 anti-malarial antigen. The total levels of IgG and its subclasses were measured using enzyme-linked immunosorbent assays (ELISA) as previously described in detail [18,19] and as recently indicated [20].…”

Section: Serum Elution From Lter-paper Samplesmentioning

confidence: 99%

Significant Differences in FcγRIIa, FcγRIIa and FcγRIIIb Genes Polymorphism and Anti-malarial IgG Subclass Pattern are Associated with Severe Malaria in Saudi Children

Aljada

Hamid²,

Elsheikh

et al. 2021

Preprint

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Background: The FcyRs genotypes have been reported to play a key role in the defence against malaria parasites through both cellular and humoral immunity. This study aimed to investigate the possible correlation between FcγR (IIa, IIIa, and IIIb) genes polymorphism and the clinical outcome for anti‐malarial antibody response of Plasmodium falciparum infection among Saudi children. Material and methods: A 600 volunteers have been enrolled in this study, including 200 malaria-free control (MFC) subjects, 218 patients with uncomplicated malaria (UM) and 182 patients with severe malaria (SM). The FcγR genotypes was analysed using PCR amplification methods, and measurement of immunoglobulins were determine using ELISA. Results: The data revealed the FcγRIIa-R/R131 showed a statistically association with the increased susceptibility to SM when compared to UM patients. Furthermore, higher levels of IgG1, IgG2, and IgG4 were associated with the FcγRIIa-H/H131 genotypes among UM patients. Although the FcγRIIa-F/V176 genotype was not associated with UM, it showed a significant association with severe malaria. Interestingly, the FcγRIIa-V/V176 genotype was This study aimed to associated with protection against SM. Moreover, severe malaria patients carrying the FcγRIIa-F/F genotype showed higher levels of AMA-1-specific IgG2 and IgG4 antibodies. The FcγRIIIb NA1/NA1 and FcγRIIIb NA2/NA2 genotypes did not show significant differences between UM and the MFC. However, the genotype FcγRIIIb-NA2/NA2 was statistically associated with severe malaria. Conclusions: The data presented in this study strongly suggest the possible impact of FcyR (IIa, RIIIa and RIIIb) gene variants and anti-malaria IgG subclasses play a role in susceptibility to malaria infection and disease outcomes in Saudi children.

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Antibody responses to P. falciparum Apical Membrane Antigen 1(AMA-1) in relation to haemoglobin S (HbS), HbC, G6PD and ABO blood groups among Fulani and Masaleit living in Western Sudan

Cited by 6 publications

References 74 publications

ABO blood group and risk of malaria during pregnancy: a systematic review and meta-analysis

ABO blood group and risk of malaria during pregnancy: a systematic review and meta-analysis

Significant differences in FcγRIIa, FcγRIIIa and FcγRIIIb genes polymorphism and anti-malarial IgG subclass pattern are associated with severe Plasmodium falciparum malaria in Saudi children

Significant Differences in FcγRIIa, FcγRIIa and FcγRIIIb Genes Polymorphism and Anti-malarial IgG Subclass Pattern are Associated with Severe Malaria in Saudi Children

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