Antibody responses to a live Newcastle disease vaccine when combined with a live infectious bronchitis vaccine

Bracewell, CD; Dawson, PS; Allan, WH

doi:10.1136/vr.90.9.248

Cited by 10 publications

(6 citation statements)

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“…Our findings using qRT-PCR support previous work (1,3,4,9,10,11,12,13,15,18) showing IBV interferes with NDV replication. Both the Mass and Ark strains of IBV interfered with the replication of the three NDV live vaccine strains tested; B1, VG/GA, and C2.…”

Section: Discussionsupporting

confidence: 91%

“…Quantitative RT-PCR was successfully used to evaluate the replication interference potential of IBV and NDV after vaccination of chickens with live vaccines administered together either in manufactured combinations or single entity preparations. Before the development of PCR technology, the majority of reports relied on assessing interference indirectly on the basis of resulting IBV and NDV immune responses (3,7,10,15,17). Some studies (1,11,18) used NDV HA activity in chick embryos to directly assess IBV interference on NDV.…”

Section: Discussionmentioning

confidence: 99%

“…The replication of IBV has been shown to interfere with NDV infections. Research has shown IBV interfered with the replication of virulent (9,10) as well as live vaccine strains (3,7,12,15). Interference has also been observed in cell culture (1,4) and embryonating chicken eggs (1,11,13,18).…”

mentioning

confidence: 99%

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Evaluating Viral Interference Between Infectious Bronchitis Virus and Newcastle Disease Virus Vaccine Strains Using Quantitative Reverse Transcription Polymerase Chain Reaction

Gelb

Ladman

Shapiro

et al. 2007

Avian Diseases Digest

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Evaluating Viral Interference Between Infectious Bronchitis Virus and Newcastle Disease Virus Vaccine Strains Using Quantitative Reverse Transcription Polymerase Chain Reaction

Gelb

Ladman

Shapiro

et al. 2007

Avian Diseases Digest

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“…Reports since the 1960 0 s have described how IBV vaccines can impair the efficacy of NDV vaccines [16,17], potentially leading to production losses [18]. Gelb et al (2007) demonstrated how NDV immunity decreased when combined with an IBV Arkansas vaccine in broiler chickens [7].…”

Section: Introductionmentioning

confidence: 99%

Comparative protective immunity provided by live vaccines of Newcastle disease virus or avian metapneumovirus when co-administered alongside classical and variant strains of infectious bronchitis virus in day-old broiler chicks

Ball¹,

Forrester²,

Herrmann³

et al. 2019

Vaccine

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a b s t r a c tThis study reports on the simultaneous administration of live NDV or aMPV subtype B vaccines alongside two live IBV (Massachusetts-H120 and 793B-CR88) vaccines in day-old maternal-antibody positive commercial broiler chicks. In the first experiment, chicks were divided into four groups; one unvaccinated and three groups vaccinated with live NDV VG/GA-Avinew, live H120 + CR88, or VG/GA-Avinew + H120 + CR88. In the second experiment, live aMPV subtype B vaccine was used in place of NDV. Clinical signs were monitored daily and oropharyngeal swabs were taken at regular intervals for vaccine virus detection. Blood was collected at 21 dpv for serology. 10 chicks from each group were challenged with virulent strains of M41 or QX or aMPV subtype B. For IBV, after 5 days post challenge (dpc), tracheal ciliary protection was assessed. For aMPV, clinical scores were recorded up to 10 dpc. For NDV, haemagglutination inhibition (HI) antibody titres were assayed as an indicator of protective immunity. In both experiments, ciliary protection for IBV vaccinated groups was maintained above 90%. The protection against virulent aMPV challenge was not compromised when aMPV, H120 and CR88 were coadministered. NDV HI mean titres in single and combined NDV-vaccinated groups remained above the protective titre (>3 log 2 ). Both experiments demonstrated that simultaneous administration of live NDV VG/GA-Avinew or aMPV subtype B alongside H120 and CR88 vaccines does not interfere with protection conferred against NDV, IBV or aMPV.

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“…In order to reduce costs, vaccination using two or three vaccines simultaneously became a common practice in poultry production, such as a combined vaccine against ND and IB. Earlier studies have reported that infectious bronchitis virus (IBV) interferes with the immune response against Newcastle disease virus (NDV) (Raggi & Lee, 1964;Bracewell et al, 1972;Thornton & Muskett, 1975). Nowadays, Gelb et al (2004) restart discussions about viral interference by means of evaluating IBV and NDV replication using a new detection technique, the Reverse Transcription Polymerase Chain Reaction (RT-PCR).…”

Section: Introductionmentioning

confidence: 99%

Effect of associated vaccines on the interference between Newcastle disease virus and infectious bronchitis virus in broilers

Cardoso

Filho

Romao

et al. 2005

Rev. Bras. Cienc. Avic.

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The phenomenon of viral interference between live vaccines against Newcastle Disease and infectious bronchitis has been reported since the 50's and many researchers have reported its prejudicial effects on avian immunization. Therefore, this study evaluated the effect of associated vaccines on the interference between Newcastle disease virus (NDV) and infectious bronchitis virus (IBV) in broilers. There were 400 broiler chicks divided into five groups. The groups were submitted to mono or polyvalent vaccinations against IBV and NDV, except for the non-vaccinated control group (CG). Sera were collected at 35 and 45 days of age and submitted to serologic tests to assess antibody levels. It was observed the occurrence of interference in the immune response against NDV by the use of associated vaccines to NDV and IBV; however, the group that was immunized with commercial combined vaccines (IBV+NDV) presented antibody titers to NDV similar to the group that was given only vaccine against NDV. We concluded based on these preliminary studies that the interference of IBV on the immune response against NDV depends also whether the association between the two vaccines is done just before vaccination or in the manufacturing laboratory

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Antibody responses to a live Newcastle disease vaccine when combined with a live infectious bronchitis vaccine

Cited by 10 publications

References 0 publications

Evaluating Viral Interference Between Infectious Bronchitis Virus and Newcastle Disease Virus Vaccine Strains Using Quantitative Reverse Transcription Polymerase Chain Reaction

Evaluating Viral Interference Between Infectious Bronchitis Virus and Newcastle Disease Virus Vaccine Strains Using Quantitative Reverse Transcription Polymerase Chain Reaction

Comparative protective immunity provided by live vaccines of Newcastle disease virus or avian metapneumovirus when co-administered alongside classical and variant strains of infectious bronchitis virus in day-old broiler chicks

Effect of associated vaccines on the interference between Newcastle disease virus and infectious bronchitis virus in broilers

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