Antibody response to Jembrana disease virus in Bali cattle

Hartaningsih, Nining; Wilcox, G. E.; Kertayadnya, G.; Astawa, M.

doi:10.1016/0378-1135(94)90082-5

Cited by 30 publications

(31 citation statements)

References 6 publications

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“…Owners of the cattle were identified and the serum samples were examined for antibody to JDV by an enzyme-linked immunosorbent assay (ELISA) as previously described [10].…”

Section: Serological Testsmentioning

confidence: 99%

The transmission of Jembrana disease, a lentivirus disease of Bos javanicus cattle

Soeharsono¹,

Wilcox

Putra³

et al. 1995

Epidemiol. Infect.

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SummaryMethods of transmission of Jembrana disease, an acute and severe disease of Bali cattle (Bos javanicus) caused by a recently-identified bovine lentivirus known as Jembrana disease virus, are described. During the acute disease virus can be detected in saliva and milk. There is evidence of direct transmission from acutely affected animals in close contact with susceptible cattle, possibly by virus in these secretions infecting cattle by the conjunctiva!, intranasal or oral routes, by which it was possible to infect cattle experimentally. During the acute disease the titre of infectious virus in blood is high, about 108 50% cattle infectious units (ID50)/ml, and it is probable that the virus is also transmitted mechanically by haematophagous arthropods. Recovered cattle are also a potential but probably infrequent source of infection; recovered cattle are persistently viraemic but the titre of infectious virus in blood decreases to about 101 ID50/ml by 60 days after recovery from the acute disease, and virus cannot be detected in secretions.

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“…Owners of the cattle were identified and the serum samples were examined for antibody to JDV by an enzyme-linked immunosorbent assay (ELISA) as previously described [10].…”

Section: Serological Testsmentioning

confidence: 99%

The transmission of Jembrana disease, a lentivirus disease of Bos javanicus cattle

Soeharsono¹,

Wilcox

Putra³

et al. 1995

Epidemiol. Infect.

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“…Due to the high mortality rate of infected cattle and the consequent economic losses, it is essential that JDV infection can be diagnosed as early as possible to limit the disease spread. Immunodiagnosis based on host humoral response can not be used in early stages of the disease as like the other lentiviruses, JDV infection induces a delayed humoral response and JDVspecific antibodies are not produced in most infected cattle untill 11 weeks post infection [7,10]. Furthermore, antibody-based diagnostic methods do not enable to distinguish JDV-from BIV-infection as the two bovine lentiviruses are antigenically very closely related [6,10].…”

Section: Discussionmentioning

confidence: 99%

“…Immunodiagnosis based on host humoral response can not be used in early stages of the disease as like the other lentiviruses, JDV infection induces a delayed humoral response and JDVspecific antibodies are not produced in most infected cattle untill 11 weeks post infection [7,10]. Furthermore, antibody-based diagnostic methods do not enable to distinguish JDV-from BIV-infection as the two bovine lentiviruses are antigenically very closely related [6,10]. Distinguishing BIV-infection was only made feasible by using a BIVspecific monoclonal antibody that only recognizes the unique BIV GAG epitope, which is not shared by JDV [14].…”

Section: Discussionmentioning

confidence: 99%

Use of reverse transcription loop-mediated isothermal amplification combined with lateral flow dipstick for an easy and rapid detection of Jembrana disease virus

et al. 2015

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Jembrana disease virus (JDV) is a viral pathogen that causes Jembrana disease in Bali cattle (Bos javanicus) with high mortality rate. An easy and rapid diagnostic method is essential for further control this disease. We used a reverse transcription loop-mediated isothermal amplification (RT-LAMP) combined with lateral flow dipstick (LFD), based on conserved tm subunit of Jembrana disease virus env gene. The RT-LAMP conditions were optimized by varying the concentration of MgSO 4 , betaine, dNTP, and temperature as well as the time and duration of reaction. The primers sensitivity for JDV was confirmed. The method was able to detect env-tm gene dilution which contained 2 9 10 -15 g of template. Comparatively, the sensitivity of RT-LAMP/LFD was 100-fold more sensitive than reverse transcription-polymerase chain reaction. The primers specificity for JDV was also confirmed using positive and negative controls. This work also showed that virus detection could be done not only on total RNA extracted from blood but various organs could also be analyzed for the presence of JDV using RT-LAMP/LFD method. The whole process, including the LAMP reaction and the LFD hybridization step only lasts approximately 75 min. Results of analysis can be easily observed with naked eyes without addition of any chemical or further analysis. The combination of RT-LAMP with LFD makes the method a more suitable diagnostic tool in conditions where sophisticated and expensive equipments are not available for field investigations on Jembrana disease in Bali cattle.

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“…The vaccine type which has been developed from spleen of JDV-infected cattle, JDVacc, is the sole that has been tested and presently commercially available and currently used to circumscribe the spread of Jembrana disease Hartaningsih et al, 2001). Neutralizing antibody is likely not the essential mechanism in recovery from acute Jembrana disease as it is detected in animals only after a prolonged period following recovery from clinical disease (Hartaningsih et al, 1994;Soeharsono et al, 1990). Despite the lack of complete efficacy, the immune response attained in vaccinates appears to be sufficient to reduce the disease severity and the virus infectivity, all the more as naturally resistent Bali cattle will also help to limit disease outbreaks (Desport et al, 2009).…”

Section: Resultsmentioning

confidence: 99%

“…Viruses are also detected in a high titer (up to 10 8 ID 50 /mL, equaling to 10 10 to 10 11 viral genome copies/ml) in the plasma fraction of the blood during the febrile state Soesanto et al, 1990;Stewart et al, 2005). The majority infected animals cultivate possible amount of antibodies to be detected only 6 weeks or more after recovery from the acute phase of the natural disease (Hartaningsih et al, 1994). The temporary immunosuppression occurring during the acute phase was demonstrated by a decrease of IgG-containing cells in the lymphoid organs (Dharma et al, 1994).…”

Section: Pathology Of Jembrana Diseasementioning

confidence: 99%

Vaccine against Jembrana Disease Virus Infection: A Summary Findings

Kusumawati¹,

Wanahari²,

Astuti³

et al. 2015

American Journal of Immunology

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Jembrana disease constitutes the main concern in cattle industry especially in Indonesia and Australia as it has caused important economic losses due to mortality of cattle. The pathology of the disease is unusual for a lentivirus infection as it is associated with a severe, often lethal disease syndrome and a short incubation period in cattle. For lack of efficient medical treatment of JDV-infected cattle, vaccination may therefore constitute an effective measure for the prevention or eradication of Jembrana disease. Up to date, only one type of vaccine has been reported and tested. It is based on inactivated, tissue-derived virus antigens (Tabanan/87 isolate, JDV TAB/87 ). This review summarize show current Jembrana disease vaccine was developed as well as evaluated and how these information might be useful in future vaccine design.

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Antibody response to Jembrana disease virus in Bali cattle

Cited by 30 publications

References 6 publications

The transmission of Jembrana disease, a lentivirus disease of Bos javanicus cattle

The transmission of Jembrana disease, a lentivirus disease of Bos javanicus cattle

Use of reverse transcription loop-mediated isothermal amplification combined with lateral flow dipstick for an easy and rapid detection of Jembrana disease virus

Vaccine against Jembrana Disease Virus Infection: A Summary Findings

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