Antibody response of growing German Holstein bulls to a vaccination against bovine viral diarrhea virus (BVDV) is influenced by Fusarium toxin exposure in a non-linear fashion

Dänicke, Sven; Winkler, Janine; Meyer, Ulrich; Kersten, Susanne; Wernike, Kerstin; Beer, Martin; Frahm, Jana

doi:10.1007/s12550-018-0307-4

Cited by 8 publications

(12 citation statements)

References 31 publications

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“…The effects of DON on laboratory animal immunoglobulin levels has been previously reviewed [ 1 , 2 ], and has been shown to result in altered Ig production in a class-dependent manner. Furthermore, previous work has shown that disruptions to antibody production are an important nonlinear toxicological outcome in this species [ 8 , 12 , 13 , 14 , 15 ], a conclusion which these data further support.…”

Section: Resultssupporting

confidence: 80%

“…As such, research into simultaneous exposures to these compounds has increased, with special attention given to their long-term effects in livestock species that ultimately enter the human food chain. Ruminants, including cattle, are generally considered tolerant of these compounds, yet numerous studies document toxicity in this group of mammals [ 6 , 7 , 8 , 9 ]. For DON, this can include decreased feed consumption and alterations in the rumen such as decreased NDF digestibility; for FUM, changes in liver enzymes and markers related to metabolism have been noted [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…As a trichothecene, DON disrupts transcription and cellular repair through processes which have been previously well reviewed [ 11 ]. One of these sequelae—inhibition of protein synthesis—appears to target the immune and gastro-hepatic systems [ 8 , 12 , 13 , 14 , 15 ]. The pathogenesis of dysfunction from fumonisin exposure is linked to the inhibition of serine palmitoyltransferase, which alters sphingolipid metabolism and disrupts cell membranes and function [ 1 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Deoxynivalenol and Fumonisins Fed in Combination to Beef Cattle: Immunotoxicity and Gene Expression

Roberts

Bionaz

Jiang

et al. 2021

Toxins

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We evaluated the effects of a treatment diet contaminated with 1.7 mg deoxynivalenol and 3.5 mg fumonisins (B1, B2 and B3) per kg ration on immune status and peripheral blood gene expression profiles in finishing-stage Angus steers. The mycotoxin treatment diet was fed for a period of 21 days followed by a two-week washout period during which time all animals consumed the control diet. Whole-blood leukocyte differentials were performed weekly throughout the experimental and washout period. Comparative profiles of CD4+ and CD8+ T cells, along with bactericidal capacity of circulating neutrophils and monocytes were evaluated at 0, 7, 14, 21 and 35 days. Peripheral blood gene expression was measured at 0, 7, 21 and 35 days via RNA sequencing. Significant increases in the percentage of CD4-CD8+ T cells were observed in treatment-fed steers after two weeks of treatment and were associated with decreased CD4:CD8 T-cell ratios at this same timepoint (p ≤ 0.10). No significant differences were observed as an effect of treatment in terms of bactericidal capacity at any timepoint. Dietary treatments induced major changes in transcripts associated with endocrine, metabolic and infectious diseases; protein digestion and absorption; and environmental information processing (inhibition of signaling and processing), as evaluated by dynamic impact analysis. DAVID analysis also suggested treatment effects on oxygen transport, extra-cellular signaling, cell membrane structure and immune system function. These results indicate that finishing-stage beef cattle are susceptible to the immunotoxic and transcript-inhibitory effects of deoxynivalenol and fumonisins at levels which may be realistically encountered in feedlot situations.

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Section: Resultssupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Deoxynivalenol and Fumonisins Fed in Combination to Beef Cattle: Immunotoxicity and Gene Expression

Roberts

Bionaz

Jiang

et al. 2021

Toxins

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“…Reduced count of segmented neutrophils, which consequently affected the total leucocyte counts, was noticed in heifers exposed to DON at 3 ppm but not at 6 ppm. Similar results were observed when exposing Holstein bulls to increasing concentrations of DON (Dänicke et al, 2018). Dietary DON at 8.31 ppm induced higher neutrophil counts than lower level (i.e., 5.66 ppm).…”

Section: Discussionsupporting

confidence: 83%

Effects of the mycotoxin metabolite de‐epoxy‐deoxynivalenol (DOM‐1) on embryo development and sperm motility in cattle

Guerrero-Netro

Barreta

Costa

et al. 2020

J of Applied Toxicology

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Contamination of animal feed with Fusarium spp results in accumulation of mycotoxins including deoxynivalenol. In animals, deoxynivalenol is metabolized to de‐epoxy deoxynivalenol (DOM‐1), which is generally considered to be a non‐toxic metabolite; however, recent studies demonstrated that DOM‐1 can reduce steroid production and induce apoptosis in the bovine ovary. The objectives of this study were to assess the effects of DOM‐1 on applied aspects of reproductive function in cattle, specifically sperm function and embryo development in vitro and follicle growth and superovulatory responses in vivo. The effect of naturally contaminated feed on superovulatory responses was assessed; a dose of 6 ppm deoxynivalenol increased blood DOM‐1 concentrations to 20 ng/ml, but this did not alter the number of viable embryos recovered on day 7. However, intrafollicular injection of DOM‐1 (100 ng/ml) directly into the growing dominant follicle resulted in cessation of follicular growth over the subsequent 3 days. Treatment with DOM‐1 reduced motility of bull spermatozoa over a 10‐h period in vitro. Addition of DOM‐1 to oocytes in vitro during IVM did not alter rates of cumulus expansion and nuclear maturation, but treatment during IVF reduced the rate of blastocyst formation. These data illustrate that DOM‐1 is more biologically active than previously thought and negatively impacted reproductive outcomes in cattle.

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“…Previous studies and reviews examining the effects of DON or FUM on fattening/finishing beef cattle identified decreased rate of body weight gain, and toxicity to the liver, kidney and immune system as the main toxic endpoints (Baker and Rottinghaus, 1999;Dänicke et al, 2005Dänicke et al, , 2018EFSA, 2017EFSA, , 2018Osweiler et al, 1993). In the present study, we utilized an average concentration in the TMR of 1.7 mg DON and 3.5 mg FUM per kg TMR in the diet in a partial crossover study with 12 black Angus steers to examine the effects of these mycotoxins on overall beef cattle physiology, along with hepatic and immune function in more depth than previous works.…”

Section: Resultsmentioning

confidence: 99%

Effects of deoxynivalenol and fumonisins fed in combination on beef cattle: health and performance indices

Duringer

Roberts

Doupovec³

et al. 2020

WMJ

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Interactions between livestock management practices and toxicological outcomes of mycotoxin exposure may explain the range of tolerable toxin levels reported for various species. In the current study, we investigated the effect of concurrent mycotoxin exposure with a high starch diet in 12 beef steers in a partial cross-over experiment using a 21-day treatment period, followed by a 14-day clearance. During the treatment period, animals were assigned to one of two diets: a low mycotoxin control total mixed ration (TMR) (0.2±0.1 mg deoxynivalenol (DON) and 0.2±0.2 mg fumonisins (FUM)/kg TMR) and a high mycotoxin TMR treatment (1.7±0.2 mg DON and 3.5±0.3 mg FUM/kg TMR). We evaluated the impacts of these mycotoxins on performance, physiology and biochemistry; and the ability of the clearance period to return animals to a naïve state in the cross-over model. The lack of acute ruminal acidosis observed indicates that the animals were able to withstand the physiological stresses of the high starch diet, while toxicological outcomes were manifested in minor perturbations of biochemistry and outright performance of exposed animals. Aspartate aminotransferase, cholesterol, fibrinogen and leukocyte count were increased while sorbitol dehydrogenase, bile acids and mean corpuscular volume were decreased in treatment-fed steers, yet were not significantly different than those from control-fed animals. Fusarium toxin exposure significantly decreased ruminal fluid pH, with the clearance period returning animals to a naïve state, as it did for most of the molecular variables measured. Conversely, treatment-fed animals continued to exhibit significantly lower average weekly body weight throughout the treatment period and the first week of the clearance period. While the risk of adverse health effects to fattening cattle from similar doses of DON or FUM as used in the current study is considered low, additional work should be directed towards minimising production losses due to these feed contaminants.

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Antibody response of growing German Holstein bulls to a vaccination against bovine viral diarrhea virus (BVDV) is influenced by Fusarium toxin exposure in a non-linear fashion

Cited by 8 publications

References 31 publications

Effects of Deoxynivalenol and Fumonisins Fed in Combination to Beef Cattle: Immunotoxicity and Gene Expression

Effects of Deoxynivalenol and Fumonisins Fed in Combination to Beef Cattle: Immunotoxicity and Gene Expression

Effects of the mycotoxin metabolite de‐epoxy‐deoxynivalenol (DOM‐1) on embryo development and sperm motility in cattle

Effects of deoxynivalenol and fumonisins fed in combination on beef cattle: health and performance indices

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