Antibody response in rats to the synthetic polypeptide (T,G)‐A‐ genetically linked to the major histocompatibility system

Günther, Eberhard; Rüde, Erwin; Stark, O

doi:10.1002/eji.1830020211

Cited by 73 publications

(22 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The immune response to thymus-dependent antigens is under the control of genes in the major histocompatibility complex in mice (1), rats (2,3), guinea pigs (4) and rhesus monkeys (5). Synthetic polypeptide antigens have been very useful in the study of the activity of these genes, which have been termed H-linked Ir genes, and which differ for distinct antigens (6).…”

mentioning

confidence: 99%

Determinants of antigenic molecules responsible for genetically controlled regulation of immune responses.

Schwartz

Waltenbaugh

Dorf

et al. 1976

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The ability of mice bearing the H-2s haplotype to develop helper responses to the random copolymer of GluMa while they developed suppressor responses to the terpolymer of GluAlaTyr suggested the crucial role of tyrosine in these peptides. On the basis of various considerations, it was postulated that many of the tyrosine residues in GluAlaTyr would be localized at the NH-terminal end of the molecule. To verify this hypothesis, a block terpolymer composed of a short sequence of homopolymer tyrosine covalently bound to the random copolymer of Glua was synthesized. The present studies, using t is block terpolymer, demonstrated that the chemical determinants stimulating helper and suppressor responses are distinct and can be present simultaneously in the same molecule. Thus, addition of COOH-terminal tyrosine residues to the Glu,Ala polypeptide converted this immunogenic molecule to an immunosuppressive molecule in mice bearing the H-2s haplotype. The mechanism by which these short sequences of tyrosine influence H-2-linked immune responses remains to be determined.

show abstract

mentioning

confidence: 99%

Determinants of antigenic molecules responsible for genetically controlled regulation of immune responses.

Schwartz

Waltenbaugh

Dorf

et al. 1976

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…In collaboration with Maurer we also demonstrated Ir gene control of the response of inbred mice to linear random copolymers of L-amino acids (34). Genetic control of immune responsiveness was also reportcd in rats (35,36), and rhesus monkeys (37), illustrating the generality of this phenomenon for different antigens and in different species.…”

Section: The Discovery Of Immune Response Genesmentioning

confidence: 63%

“…Similarly the GT gene and the genes controlling responsiveness to limiting doses of DNP-GPA were found to be linked to the major H locus of strain 13 guinea pigs. Linkage of Ir genes to the MHC of the rat (35,36) and rhesus monkey (37) was also established, illustrating the general significance of the finding. In contrast, Ir genes were shown not to be linked to the structural genes for the H chain of immunoglobulins (39).…”

Section: Linkage Of Ir Genes To the Major Histocompatibility Complexmentioning

confidence: 77%

The Role of MHC Gene Products in Immune Regulation and its Relevance to Alloreactivity

Benacerraf¹

1992

Scand J Immunol

View full text Add to dashboard Cite

The immune system has evolved the capacity to react specifically with a very large number of foreign molecules with which it had no previous contact, while avoiding reactivity for autologous molecules, naturallyantigenic in other species or in other individuals of the same species.Immunological research has been directed to the elucidation of this phenomenon ever since Ehrlich (1) proposed that immunocompetent cells bear receptors for antigen identical with the antibodies to be produced. Gowans (2) identified lymphocytes as the cells responsible for immune phenomena. Burnet (3) proposed the clonal selection theory of immunity which postulated that: 1) lymphocytes differentiate as clones bearing antibody receptors of unique specificity, 2) antibody responses reflect the selective expansion of specific lymphocytes, following the binding of antigen, and their differentiation as secretors of antibody, identical in specificity with the antigen binding receptors on the original clones. The Burnet hypothesis was verified experimentally (4,5,6) and was accepted as a major advance, concerned primarily with the response of antibody producing cells, later identified as B lymphocytes (7) and plasma cells. Accordingly, studies on the specificity of antibodies and on the structure of immunoglobulins revealed that these molecules (8,9) and their structural genes (10,ll) evolved in a way that ensures the enormous diversity of antibody combining sites observed.The discovery by Miller (12) and by Good (13) that lymphocytes differentiate into two separate classes of cells (T and B) with distinct functions, the identification of cellular immune phenomena mediated by T cells (14) and the demonstration that immune responses are regulated by helper (15,16,17) and suppressor (18,19) cells and by macrophages (20) emphasized the complexity of the immune system and the critical role played by T lymphocytes in the regulation of immunity.It became increasingly apparent that the clonal selection theory, although correct, did not take into account the complex cellular and molecular interactions essential to immune phenomena or the restrictions these interactions dictate in the specificity of T cells. An additional system, beside specific immunoglobulins, involving the products of the major histocompatibility complex (MHC) was shown to be critically involved in the manner by which T cells 597

show abstract

“…Further work with inbred strains of mice, also employing synthetic polypeptide antigens, revealed the existence of several Ir genes in tbat species and made way for the startling discovery that the Ir genes were located within the major histocompatibility complex (MHC) -tbat in fact the Ir genes are histocompatibility genes (26), The same genomic location of Ir genes bas been demonstrated in the guinea pig (11), rat (16), and rhesus monkey (9), illustrating the generality of the phenomenon.…”

mentioning

confidence: 89%

Immune Response Genes

Werdelin

1982

Allergy

View full text Add to dashboard Cite

Antibody response in rats to the synthetic polypeptide (T,G)‐A‐ genetically linked to the major histocompatibility system

Cited by 73 publications

References 11 publications

Determinants of antigenic molecules responsible for genetically controlled regulation of immune responses.

Determinants of antigenic molecules responsible for genetically controlled regulation of immune responses.

The Role of MHC Gene Products in Immune Regulation and its Relevance to Alloreactivity

Immune Response Genes

Contact Info

Product

Resources

About