Immune Response Genes

Ia antigens in rat kidney, with special reference to their expression in tubular epithelium.

“…Counts were made in the subcapsular cortex, midcortex a n d cortico-medullary areas of the kidneys a n d are expressed as means of dendritic cells from 10 high power fields (the standard error of the m e a n did not exceed 2 in a n y instance). In the first experiment, respective counts were:-DA: 14 Expression of Ia Antigen on B Lymphocytes. The differences in expression of Ia antigens in renal epithelium were not reflected in the levels of expression of surface Ia antigen by B lymphocytes.…”

“…Thymic epithelium, while a nonlymphoid cell-type, expresses Ia antigens in a lymphoid environment (9, 10). Ia molecules may be Ir gene products (11) and it has been suggested that they could represent primary recognition receptors for antigen (12,13,14).Ia antigens have recently been described in association with a number of nonlymphoid cells, including vascular endothelium (15) and a number of epithelia in guinea pigs (16,17), man (18-21), mice (22,23), and rats (24-26). The work of Hart and Fabre (24) and Mayrhofer et al ( 26) strongly suggests that the Ia antigens are synthesized by the epithelial cells and not passively acquired.…”

“…Thymic epithelium, while a nonlymphoid cell-type, expresses Ia antigens in a lymphoid environment (9, 10). Ia molecules may be Ir gene products (11) and it has been suggested that they could represent primary recognition receptors for antigen (12,13,14).…”