Antibody response achieved by different rabies prophylaxis methods

Tülek, Necla; Senocak, Halil; Yetkin, Arzu; Ün, Hikmet; Aylan, O.

doi:10.1016/j.ijid.2005.02.007

Cited by 6 publications

(5 citation statements)

References 3 publications

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“…Protective antibodies rate in the late phase, approximately 28 days after the last dose of vaccine was 71% among patients who were administered the rabies immune globulin and 5-dose vaccine. It was in concordance with the literature [17,18,22,23].…”

Section: Discussionsupporting

confidence: 93%

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Efficacy of antibody levels in different post-exposure rabies vaccination programs

et al. 2016

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Objectives. Rabies is a fatal acute viral zoonotic disease causing encephalomyelitis in humans and many other mammalian animals. Prophylaxis is vital since there is no treatment for rabies. This study was a comparison of antibody levels in patients who were vaccinated following different vaccinationprotocols. Methods. Eightyfive patients who were included in the rabies vaccination program who presented to the vaccination center of our clinic with the complaint of suspicious contact with rabies were included the study. In 61 (71.8%) patients a 2-1-1 vaccine program (Zagreb regimen) was implemented, and in 24 (28.2%) patients, a 5-dose rabies vaccine and rabies immune globulin (RIG) in a dose of 40 IU/kg (Essen regimen) was applied. Results. In patients on the 2-1-1 vaccine program, antibody levels on the 21 st day were greater than 0.5 IU/ml in 49 (80.3%) patients. Antibody levels on the 28 th day in the group that received the 5-dose rabies vaccine and rabies immune globulin administration was greater than 0.5 IU/ml in 17 (70.8%) patients. The difference between the two groups of vaccination programs was not statistically significant (p=0.344). Seroconversion rates for approximately one month after the last dose of vaccination in the serum samples were 90% and 75% in the groups with 2-1-1 vaccination, and RIG and 5-dose vaccinations, respectively. The differences were not statistically significant (p=0.071). Conclusions. Identification of similar seroconversion rates suggests that the 2-1-1 vaccination program may be a good alternative option to the standard vaccination program when RIG is unavailable.Eur Res J 2016;2(1):36-41

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Section: Discussionsupporting

confidence: 93%

“…In this study, protective antibodies rates were determined as 80.3% and 90.2% for each vaccine program. It was compatible with the literature [16][17][18][19][20][21][22].…”

Section: Discussionsupporting

confidence: 90%

Efficacy of antibody levels in different post-exposure rabies vaccination programs

et al. 2016

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“…This figure has declined, in parallel with the reduction in rabies in dogs (Fig. Most were treated with a five-dose intra-muscular course of vaccine (human diploid cell vaccine or VERO cell vaccine) and rabies immunoglobulin following WHO guidelines [13]. Unfortunately, reporting of human cases has been sporadic, either within the scientific literature [12] or in the national press.…”

Section: Rabies In Humansmentioning

confidence: 99%

“…In 2003, over 100 000 animal bites were recorded by the Turkish Ministry of Health. Most were treated with a five-dose intra-muscular course of vaccine (human diploid cell vaccine or VERO cell vaccine) and rabies immunoglobulin following WHO guidelines [13]. A case study of four deaths resulting from rabies in Turkish nationals [14] demonstrates the importance of reacting rapidly to an animal bite whether from a domestic animal or wildlife as two of the cases resulted from bites by wild animals, in one case a fox.…”

Section: Introductionmentioning

confidence: 99%

Rabies epidemiology and control in Turkey: past and present

Johnson¹,

Ün²,

Fooks³

et al. 2009

Epidemiol. Infect.

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SUMMARYTurkey is the only country in Europe where urban dog-mediated rabies persists. Control measures in recent decades have reduced the burden of rabies to relatively low levels but foci of disease still persist, particularly in urban areas. Occasional human cases result from this persistence although the source of these appears to be both dog and wildlife reservoirs. This review considers the current state of rabies in Turkey including current control measures, the varying epidemiology of the disease throughout this country and the prospects for rabies elimination.

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“…Rabies is one of the neglected tropical zoonotic diseases caused by a virus. It belongs to the Rhabdoviridae [1]. It is a disease that is commonly found in animals but can quickly affect humans [2,3].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Knowledge, Attitude, Perception and Practices on Rabies Disease in the GA East Municipality, Ghana

Vetsi

Gyamfi²,

Sarfo-Twerefour

2021

AJRID

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Background: Rabies is one of the neglected tropical zoonotic diseases caused by a virus. It belongs to the Rhabdoviridae [1]. It is a disease that is commonly found in animals but can easily effect human [2]. Where there are animal reservoirs, rabies is commonly spread. The general objective of this study to evaluate differences in knowledge, attitude and perception about rabies, among the residence in Ga East. Methods: A cross-sectional study was used in this study using purposive sampling technique. Data was collected by interviewing study participants using OKD Collection and also STATA version14.2 was used for data analysis Results: A total of 475 respondents were involved in the study with 354 (74.53%) males and 121(25.47%) as females. Of this, majority of the participants (93.47%) own a dog against 6.53% who did not own a dog. Dog is own in the community basically for security purposes (77.25%). Few own dog for leisure. The study document less than 50% of the respondents [186 (39.16%)] resort to local drug stores drug store for first aid following a dog bit. Seeking veterinary attention (12.84%) and properly clearing of wound (8.84%) was not a common practice. Participants were of the opinion that tetanus vaccination should be done first (29.05%). Most of the participants have heard about rabies (96.42%) and showed various degree of knowledge on source of rabies, common animals associated with rabies, symptoms of rabies. Among some other practices, any identified rabid dog is killed as indicated by majority of the participants (52.63%). Most participants (71.58%) knew that rabies vaccination serves as preventive measures against rabies and further perceived all dogs must be vaccinated (38.32%). Of the total respondents, most (63.74%) never sent their dog for routine medical check-up nor vaccinated their dogs (70.95%). Conclusion: The study revered that dog owners do not provide adequate care for their dogs. In addition to low coverage of dog vaccination and human anti rabies vaccination in the community which poses a greater threat to the lives community, the potential for increased spread of the diseases is high due to inadequate level of knowledge, poor perceptions, and attitudes towards rabies.

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Antibody response achieved by different rabies prophylaxis methods

Cited by 6 publications

References 3 publications

Efficacy of antibody levels in different post-exposure rabies vaccination programs

Efficacy of antibody levels in different post-exposure rabies vaccination programs

Rabies epidemiology and control in Turkey: past and present

Assessment of Knowledge, Attitude, Perception and Practices on Rabies Disease in the GA East Municipality, Ghana

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