1990
DOI: 10.1096/fasebj.4.8.2110538
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Antibody production in vitamin A‐depleted rats is impaired after immunization with bacterial polysaccharide or protein antigens

Abstract: Vitamin A nutritional status has been implicated as important in maintaining the integrity of immune functions. We have determined the effect of vitamin A (retinol) depletion on the ability of young animals to produce antibodies after challenge with various bacterial antigens. Male Lewis rats raised on vitamin A-free or adequate diets were immunized either near 40 days of age, before signs of vitamin A deficiency were apparent, or near 47 days of age when symptoms of deficiency were beginning to be manifest. F… Show more

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Cited by 91 publications
(53 citation statements)
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“…The synthesis of antibodies to T-cell-dependent antigens is typically depressed during vitamin A deficiency, as shown in several animal models (58,100,140,158). The evidence for an association between vitamin A status and T-cell-dependent antibody response is reviewed below.…”
Section: T-cell-dependent Humoral Responsesmentioning
confidence: 99%
“…The synthesis of antibodies to T-cell-dependent antigens is typically depressed during vitamin A deficiency, as shown in several animal models (58,100,140,158). The evidence for an association between vitamin A status and T-cell-dependent antibody response is reviewed below.…”
Section: T-cell-dependent Humoral Responsesmentioning
confidence: 99%
“…ATRA is required for optimal production of neutrophils, NK (natural killer) cells and B-cells [28], and it can promote humoral immune responses to pathogens [29,30].…”
Section: Introductionmentioning
confidence: 99%
“…and type 2 (polysaccharide) antigens [5]. The secondary response to tetanus toxoid also was very low in VA-deficient rats [6,7].…”
mentioning
confidence: 95%