Antibody-positive paraneoplastic neurologic syndromes

Abstract

FDG-PET imaging is useful in tumor screening of patients with antineuronal antibodies, but should be complemented by CT scanning to increase sensitivity and accuracy of tumor diagnosis.

Managing Paraneoplastic Neurological Disorders

“…In adult patients, the tumor search should be directed at the most common underlying tumors, that is, high-resolution CT of the chest and abdomen, and gynecological examination and mammography (or MRI of the breasts) [56]. When this is negative, FDG-PET should be considered [22,61].…”

Whole-Body 18F-FDG PET and 18F-FDG PET/CT in Patients with Suspected Paraneoplastic Syndrome: A Systematic Review and Meta-Analysis of Diagnostic Accuracy

“…Recent studies investigated the performance of whole-body 18 F-FDG PET/CT in relation to paraneoplastic antibody status (16). Several studies showed that whole-body 18 F-FDG PET and 18 F-FDG PET/CT are highly useful in the screening of patients with suspected paraneoplastic syndrome and positive paraneoplastic antibodies (9,10). However, a recent study by Vatankulu et al suggested that paraneoplastic antibody presence should not be an indispensable factor for performing 18 F-FDG PET/CT in patients suspected of harboring a paraneoplastic syndrome (16).…”

“…The details of the study design, patient demographics and characteristics, paraneoplastic presentation, paraneoplastic antibody status, index test, proportion of patients diagnosed with underlying malignancy, and reference standards of each included study were summarized in Supplemental Tables 2 and 3 (3,5,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(28)(29)(30)(31). Among the 24 studies included in the qualitative assessment, 4 studies were prospective and 20 studies were retrospective.…”

“…To assess the eligibility of the remaining 36 records, we retrieved the corresponding full texts or contacted the study authors inquiring about more information. Ultimately, a total of 24 studies were included in the qualitative assessment, and 21 studies met our predefined criteria to be included in the quantitative analysis (3,5,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37).…”

“…18 F-FDG PET and 18 F-FDG PET/CT have emerged as practical imaging modalities that allow for the detection of metabolically active tumors (6). Several studies have attempted to address the role of whole-body 18 F-FDG PET and 18 F-FDG PET/CT in the workup of patients with suspected paraneoplastic manifestations (3,5,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Although some of these studies have shown promising results, they were mostly conducted in relatively small and preselected patient populations.…”