Abstract:Micropolyspora faeni is an etiologic agent of hypersensitivity pneumonitis, a disease with an ill-defined mechanism of pathogenesis. Many reports have suggested an immunologic mechanism. A number of laboratories have demonstrated a nonantibody-mediated activation of the complement cascade. This study was undertaken to define the pathway of the complement consumption induced by M. faeni. We utilized an extract of M. faeni grown on synthetic media rather than the more common double dialysis extracts. Complement … Show more
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