The influence of pre-sowing seed treatments of selenium nanocitrates (SeNPs) and application of soil formed microorganism consortium (biological preparation (BP) Extrakon) on wheat plants infected with wheat streak mosaic virus (WSMV) were investigated in greenhouse and fields conditions in 2018-2019 (on territories of Zabolotny Institute of Microbiology and Virology of NASU).The pre-sowing seed treatments of 1% selenium nanocitrates (SeNPs) with application of BP Extrakon initiating the growth of juvenile wheat in laboratory experiments were found.In the field experiment on variants of WSMV-infected plants, two weeks after inoculation (tillering stage), we observed the appearance of characteristic symptoms of yellow mosaic with intermittent strokes on the leaves. In the boot phase, a lag in the growth of WSMV-infected plants compared with intact plants was already clearly visible, which was confirmed by the ELISA test.It was shown, increase of the quantum efficiency of PS II (F v /F p ) of WSMV-infected plants at pre-sowing treatment of 1% SeNPs and application of microbial consortium (BP Extrakon) compared with virus-infected plants without treatment.In plant tissue of all experimental variants increase activity of superoxide dismutase was shown. It was shown more significant increase of the SODactivity on the variant of WSMV-infected plants with application of BP Extrakon