Antibody-Conjugated Silica-Modified Gold Nanorods for the Diagnosis and Photo-Thermal Therapy of Cryptococcus neoformans: an Experiment In Vitro

Xiao, Qin; Lu, Yongzhou; Chen, Min; Chen, Bin; Yang, Yuming; Cui, Daxiang; Pan, Bo; Xu, Nan

doi:10.1186/s11671-018-2487-4

Cited by 5 publications

(4 citation statements)

References 40 publications

(49 reference statements)

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“…TEM images of NRs coated with SiO 2 are shown in Figure a. During the whole SiO 2 coating formation, the concentration of cetyltrimethylammonium bromide (CTAB) surfactant was controlled and tetraethyl orthosilicate (TEOS) was used as a precursor of silica for NPs functionalization. − According to our results, the thickness of the coating can be changed by varying the concentration of the CTAB surfactant in solution. The hydrolysis and condensation of TEOS during the formation of SiO 2 can be catalyzed by a change in pH.…”

Section: Resultsmentioning

confidence: 76%

Laser-Induced Optoacoustic Spectroscopy Studies of Inorganic Functionalized Metallic Nanorods

et al. 2019

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Plasmonic nanoparticles can be used in photothermal therapy thanks to their ability to generate local heat. The light-to-heat conversion efficiency is crucial for therapeutic and diagnostic applications. The photothermal properties of gold nanorods functionalized with silica layers of controllable thickness were characterized using both theoretical and experimental approaches. The time-resolved laser-induced optoacoustic spectroscopy (LIOAS) was used to determine the amount of absorbed energy that changed promptly into heat. The heat generation efficiencies were simulated by the means of finite integration technique. The obtained parameters were correlated with silica thickness. Experimental results are consistent with theoretical predictions; thus, LIOAS is a unique reliable method for studying photothermal effect in gold nanoparticles.

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Section: Resultsmentioning

confidence: 76%

Laser-Induced Optoacoustic Spectroscopy Studies of Inorganic Functionalized Metallic Nanorods

et al. 2019

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“…The synthesis of gold nanorods (AuNRs) is of considerable interest owing to their unique optical properties, which can be used for imaging, surface‐enhanced Raman spectroscopy (SERS), diagnostics, sensing, and biological applications . Murphy et al .…”

Section: Introductionmentioning

confidence: 99%

Gram‐Scale Synthesis of Isolated Monodisperse Gold Nanorods

Khanal

Zubarev

2018

Chemistry A European J

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Although gold nanorods (AuNRs) have strong potential applications in nanotechnology, plasmonics, and sensing, the scale‐up synthesis of isolated AuNRs in gram quantities remains a challenge. Nearly all previously reported methods produce aqueous solutions of cetyltrimethylammonium bromide (CTAB)‐coated AuNRs in milligram quantities with yields of approximately 20–30 % in terms of AuI to Au0 conversion. In addition, it is difficult to remove the CTAB bilayer from the surface of AuNRs and yet make them soluble and functionalized for further processing and chemical modification. This report describes the synthesis of monodisperse functionalized AuNRs (standard deviation, σ≈5 %) in gram quantities. Our approach involved increasing the concentration of HAuCl4⋅3 H2O in the growth solution to produce larger quantities of starting AuNRs and further reducing the remaining AuI ions onto the surface of AuNRs. The slow and controlled addition of ascorbic acid as a reducing agent continued the conversion of AuI into Au0 (through a disproportionation reaction) onto the surface of the nanorods, which maintained their uniform morphology without creating any unwanted impurities of various shapes. In addition, this approach significantly narrowed the size distribution owing to continuous growth of the partially grown AuNRs during the initial stage of the synthesis. To isolate a 1 g quantity of the AuNRs and to make them functionalized for further chemical reactions, a ligand‐exchange approach was utilized, in which the CTAB surfactant was replaced with 4‐mercaptophenol. The thiol group from 4‐mercaptophenol formed a covalent bond with the surface of the AuNRs, leaving free functional OH groups available for further chemical coupling reactions. For the ligand‐exchange process, a concentrated solution of 4‐mercaptophenol in tetrahydrofuran solution was introduced into the AuNRs solution. Pure AuNRs functionalized with 4‐mercaptophenol were isolated by dispersion and rinsing with an excess amount of THF, followed by centrifugation.

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“…Many inorganic nanosystems have both imaging and treatment feasibility, such as SIONs used for MRI and thermal therapy, 168 AuNPs for CT and radiation therapy, 169 gold nanorods for CT contrast enhancement, and PTT. 170 Both, all-in-one and one-for-all design approaches, possess merits and demerits. The aspects most remarkably discriminating the two approaches are clinical translationmanufacturing methodologies and presumable toxicity.…”

Section: Discussion and Perspectivesmentioning

confidence: 99%

Section: Discussion and Perspectivesmentioning

confidence: 99%

New insights into nanosystems for non-small-cell lung cancer: diagnosis and treatment

et al. 2023

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Antibody-Conjugated Silica-Modified Gold Nanorods for the Diagnosis and Photo-Thermal Therapy of Cryptococcus neoformans: an Experiment In Vitro

Cited by 5 publications

References 40 publications

Laser-Induced Optoacoustic Spectroscopy Studies of Inorganic Functionalized Metallic Nanorods

Laser-Induced Optoacoustic Spectroscopy Studies of Inorganic Functionalized Metallic Nanorods

Gram‐Scale Synthesis of Isolated Monodisperse Gold Nanorods

New insights into nanosystems for non-small-cell lung cancer: diagnosis and treatment

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