Antibodies to Type II Collagen in Relapsing Polychondritis

Foidart, Jean Michel; Abe, Shigeto; Martin, George R.; Zizic, Thomas M.; Barnett, Eugene V.; Lawley, Thomas J.; Katz, Stephen I.

doi:10.1056/nejm197811302992202

Cited by 417 publications

(171 citation statements)

References 32 publications

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“…Inflammatory arthritis, with destruction and erosion of articular cartilage, is associated with the development of autoimmunity to type I1 cartilage collagen (1)(2)(3)(4)(5)(6)(7)(8) and to cartilage proteoglycan (3)(4)(5)(9)(10)(11)(12), and this may be related to the immunopathology of the disease. The immunity expresses itself through both the production of autoantibodies and the development of T cell-mediated cellular immunity.…”

mentioning

confidence: 99%

Proteoglycan‐induced arthritis in balb/c mice

Glant

Mikecz

Arzoumanian

et al. 1987

Arthritis & Rheumatism

264

169

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Immunization with chondroitinase ABC-digested fetal human cartilage proteoglycan and Freund's complete adjuvant induced polyarthritis and ankylosing spondylitis in female BALB/c mice. The initial external symptoms of the joint inflammation were swelling and redness. This was associated with edema of the synovium and periarticular tissues and gross proliferation of cells, which reached a peak during weeks 7-9 of the experiment. Mononuclear cell infiltration, with perivascular concentration and occlusion of small vessels, was common. Synovitis increased in severity, villous pannus developed, and erosions of bone, articular cartilage, and occasionally, growth plate were observed. The lumbar spine and the proximal intervertebral discs of the tail also exhibited inflammatory and degenerative changes. As the arthritis progressed, sometimes with acute in- flammatory exacerbations, more joints became involved and, by the sixteenth to the twentieth weeks of the experiment, a progressive polyarthritis, with gross joint deformities and restricted function, developed in the majority of the limb joints. Clinical and morphologic features of the disease correlated well with radiologic analysis and with an increased deposition of wmT~-methylene diphosphonate (determined by radionuclide imaging). The development of this arthritis was accompanied by the expression of cell-mediated and humoral immunity to the immunizing antigen. However, this immunity was also observed, although it was generally less well developed, in mice that received the intact or digested proteoglycan without adjuvant. These mice did not usually develop arthritis. Control mice that received only adjuvant did not develop arthritis.Inflammatory arthritis, with destruction and erosion of articular cartilage, is associated with the development of autoimmunity to type I1 cartilage collagen (1-8) and to cartilage proteoglycan (3)(4)(5)(9)(10)(11)(12), and this may be related to the immunopathology of the disease. The immunity expresses itself through both the production of autoantibodies and the development of T cell-mediated cellular immunity. Whereas in rheumatoid arthritis, immunity is often directed against type I1 cartilage collagen (7,13,14)-particularly to its degraded form (2-5)-i n ankylosing spondylitis, immunity to cartilage proteoglycan has been detected more frequently (3,9).Destruction of articular cartilage in experimentally induced synovitis (8,(15)(16)(17) and osteoarthritis (18) also results in the development of cellular immmity to cartilage collagen and proteoglycan. Injection of

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mentioning

confidence: 99%

Proteoglycan‐induced arthritis in balb/c mice

Glant

Mikecz

Arzoumanian

et al. 1987

Arthritis & Rheumatism

264

169

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“…Pathophysiologic mechanisms clearly involve humoral and cell-mediated immune responses. A typical, but far from specific, finding is the presence of anti-type I1 collagen antibodies in the majority of patients (20)(21)(22). Some authors have found evidence of cell-mediated immune responses directed toward cartilage components (23,24).…”

Section: Discussionmentioning

confidence: 99%

Susceptibility to relapsing polychondritis is associated with hla–‐dr4

Läng

Rothenfusser

Lanchbury

et al. 1993

Arthritis & Rheumatism

129

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Objective. To determine the frequency of HLA class I1 antigens in Caucasian central European patients with relapsing polychondritis (RP).Methods. HLA class I, DR, and DQ specificities were identified in 41 patients with RP, and the frequen- cies were compared with those in 204 healthy, unrelated control subjects. HLA typing was performed using the standard complement-dependent microcytotoxicity assay. HLA-DR genotyping of 12 DR4-positive RP patients and 57 controls was performed by allele-specific oligonucleotide probing after amplification of genomic DNA by polymerase chain reaction.Results. A significant increase in DR4 antigen frequency was found in the patients (56.1%) as compared with that in healthy controls (25.5%) (P,,, < 0.001). Genotyping of DR4-positive patients and controls revealed no predominance of any DR4 subtype.Conclusion. There are important clinical similarities and overlaps between RP and rheumatoid arthritis (RA). In RA, the association with DR4 has been well established. Our findings show that although there is a DR4 association with RP, the situation is sufficiently distinct from that of RA to imply considerable differences in pathogenesis of the two conditions.Relapsing polychondritis (RP) is an episodic, progressive, and inflammatory disease of cartilaginous structures which may be accompanied by inflammatory lesions of the special sense organs, the joints, and the cardiovascular system (1). It is found with equal frequency among men and women, and has been observed in all races. Family occurrence has yet to be reported.RP and rheumatoid arthritis (RA) share several clinical symptoms and signs. Both diseases occasionally occur in the same individual (1-8). Susceptibility to the development of RA is highly associated with specific HLA-DRB1 alleles, namely,

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“…A policondrite estaria relacionada a anticorpos ao colágeno do tipo II presente nas cartilagens, no trato uveal e na notocorda, porém não no sistema nervoso central maduro 9,16,20 . Estes anticorpos têm sido encontrados em indivídu-os nas crises agudas de policondrite 16,20,21 . A susceptibilidade à doença parece também estar relacionada aos antígenos do complexo HLA-DR4 22,23 .…”

Section: Três Ou Mais Características Presentes E Confirmação Por Bióunclassified

Policondrite recidivante associada a meningoencefalite: relato de caso

Brucki

Rocha

2001

Arq. Neuro-Psiquiatr.

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RESUMO -Policondrite é entidade com acometimento recorrente de qualquer cartilagem, principalmente nasal e auricular, apresenta evolução progressiva e recorrente. Está raramente associada a afecção do sistema nervoso. Descrevemos um paciente cuja manifestação inicial foi de meningoencefalite, com posterior recorrência do quadro seguido de condrite auricular e nasal. Essa associação distingue-se pela raridade e pelo fato de que o quadro neurológico antecedeu a policondrite. Seu reconhecimento permitiu o tratamento adequado e evolução satisfatória com corticosteróides e methotrexato.PALAVRAS-CHAVE: policondrite recidivante, meningoencefalite, meningite, sistema nervoso central. Relapsing polychondritis associated with meningoencephalitis: case reportABSTRACT -Polychondritis is a disease manifesting as an episodic inflammation of cartilagenous structures throughout the body with progressive course. We describe a patient with a presentation picture of two episodes of meningoencephalitis and after the outcome with polychondritis. Neurological involvement is rare in this disease as neurologic presenting symptoms do. The diagnostic precision was determinant for a satisfactory outcome with corticosteroids and methotrexate.

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Antibodies to Type II Collagen in Relapsing Polychondritis

Cited by 417 publications

References 32 publications

Proteoglycan‐induced arthritis in balb/c mice

Proteoglycan‐induced arthritis in balb/c mice

Susceptibility to relapsing polychondritis is associated with hla–‐dr4

Policondrite recidivante associada a meningoencefalite: relato de caso

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